Вплив лізоцимовмісного зубного еліксиру на м’які тканини порожнини рота у хворих на червоний плоский лишай при стоматологічній патології

Abstract

Изучено состояние процессов перекисного окисления липидов в слюне больных типичным красным плоским лишаем кожи (КПЛ) в сочетании с хроническим генерализованным пародонтитом (ХГП). Полученные данные свидетельствуют о сниженной у этих больных резистентности к перекисному окислению, что может быть одним из механизмов повреждения тканей полости рта. Разработан комплекс лечебно-профилактических мероприятий, в который входят: системная терапия КПЛ, профессиональная гигиена полости рта с использованием зубного эликсира «Лизомукоид», лечебно-профилактической зубной пасты «Лакалут актив». Предложенный метод терапии оказался достаточно эффективным для лечения ХГП на фоне ЧПЛ; Досліджено стан процесів перекисного окиснення ліпідів у слині хворих на типовий червоний плоский лишай шкіри (ЧПЛ) в поєднанні з хронічним генералізованим пародонтитом (ХГП). Одержані дані свідчать про зниження в цих хворих резистентності до перекисного окиснення, що може бути одним із механізмів ушкодження тканин порожнини рота. Розроблено комплекс лікувально-профілактичних заходів, до якого входять: системна терапія ЧПЛ, професійна гігієна порожнини рота із застосуванням зубного еліксиру «Лізомукоїд», лікувально-профілактичної зубної пасти «Лакалут актив». Запропонований метод терапії виявився досить ефективним для лікування ХГП на тлі ЧПЛ типової форми; Prevalence and severity of generalized parodontitis depend especially on the course of diseases affecting the oral mucosa and those ones which are characterized by involvement of the oral mucosa. These diseases include mainly lichen planus. The common pathogenic agent of generalized parodontitis and lichen planus as well as of combination of them is inflammation, as generalized parodontitis is inflammation of parardontium tissue characterized by destruction of periodontium and dental ligamentous apparatus of the alveolar bone and lichen planus is a chronic inflammatory disease of skin and oral mucosa. The purpose is to study processes of lipid peroxidation in the saliva of patients with lichen planus of the skin along with chronic generalized parodontitis. The study involved three groups of patients: Group 1was represented by patients with generalized parodontitis associated with typical form of lichen planus of skin (12 individuals). Group 2 involved patients with chronic generalized parodontitis without comorbidities, lichen planus in particular (19 individuals). Group 3 was represented by apparently healthy donors (control group) (19 individuals). Complete examination of parodontium tissue was carried out for all patients. The parodontium condition was estimated on the basis of patients’ complaints, dental examination over time with assessment of basic hygienic and parodontal indices. Unstimulated mixed saliva of patients and control group were used as the material for study of lipid peroxidation processes at organ level. In order to estimate level and character of free-radical oxidation 4 indices were applied: TBA-active products level, activity of catalase, superoxide scavenger and functional index of free-radical oxidation. It has been established that in patients with chronic generalized parodontitis as well as in patients with chronic generalized parodontitis combined with lichen planus increased level of end products of lipid peroxidation processes is observed. However, in patients with lichen planus significantly (1.8 times as much) increased content of TBA-active products indicating more pronounced activation of processes of lipid peroxidation at organ level in these patients is observed. Activity of antioxidant defense enzymes in the saliva of patients is decreased. Dramatic changes are apparent in activity of SOD in patients of both groups under study. The obtained data showed the decreased resistance to peroxidation at organ level and can be considered as one of mechanisms of affecting of oral cavity tissues. The study that has been carried out proved influence of oxidative stress in pathogenesis of lichen planus and ground the necessity to use antioxidants and antihypoxants in complex therapy. Taking the obtained data into consideration, complex therapy including systemic treatment of lichen planus and topical treatment of chronic generalized parodontitis was indicated to patients with combined course of lichen planus of typical form and chronic parodontitis of primary and mild degree. The clinical study has made it possible to establish that complex of medical and preventive measures such as systemic treatment of lichen planus, advanced hygienic care of the oral cavity with the use of Lizomucoid mouthwash, Lacalut aktiv therapeutic toothpaste is rather effective for treatment of chronic generalized parodontitis associated with lichen planus of typical form.