Значення окремих імуногенетичних факторів крові у формуванні тиреоїдного статусу та ліпідному обміні за умов пролонгованого впливу малих доз радіації

Abstract

Досліджували значення еритроцитарних систем АВ0 та Rhesus, а також сироваткової системи гаптоглобінів у формуванні тиреоїдного статусу та ліпідному обміні за умов пролонгованого впливу малих доз радіації. Встановили, що у контрольній групі аналізовані імуногенетичні фактори беруть певну участь у регуляції обміну ліпідів і практично не впливають на тиреоїдний статус. У осіб з радіаційно забруднених територій нівелюється можливість включення даних факторів у регуляцію ліпідного обміну, що свідчить про порушення адаптаційних можливостей у даної категорії населення; Исследовали значение эритроцитарных систем АВ0 и Rhesus, а также сывороточной системы гаптоглобина в формировании тиреоидного статуса и липидном обмене в условиях пролонгированного влияния малых доз радиации. Установили, что в контрольной группе анализируемые иммуногенетические факторы принимают определенное участие в регуляции обмена липидов и практически не влияют на тиреоидный статус. У лиц из радиационно-загрязненных территорий нивелируется возможность включения данных факторов в регуляцию липидного обмена, что свидетельствует о нарушении адаптационных возможностей в данной категории населения; We studied the meaning of some immunogenetic blood factors in forming of thyroid status and lipid metabolism under conditions of prolonged impact of low dose radiation. There are many evidences that the immunogenetic factors of blood can play an important role in different humandiseases. However, the results are often contradictory. It is believed that the problem of interpretation of the consequences of the research is the presence of a number of related factors. In particular, the strength and severity of manifestation of immunogenetic factors may be influenced by geographical, epigenetic, environmental factors, socio-economic living conditions, which are able to lead to increased emotional stress. We have analyzed the data of 170 students of National University of Cherkasy, aged 18-24, including control group of 70 persons. The rest are residents of areas of enhanced radiation monitoring (IV radiation zone, the density of soil contamination with isotopes 137Cs is 3.7 104 – 18.5 104 Bq/m2), 100 people. All examined at the time of research not having any acute diseases. We determined the level of thyroid stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) in blood serum. We also studied the phenotype of immunogenetic systems AB0, Rh (Rhesus) and Hp (haptoglobin). The received data of the control group are largely consistent with the literature; however, the implementation of immunogenetic factors impact on lipid metabolism is realized only under additional emotional stress. Individuals in the control group with the phenotypes A(II), Rh- and Hp 2-2 under the conditions of emotional stress prove to have the higher level of cholesterol and LDL cholesterol. The identified features may be caused to the fact that the respondents belonged to a group of healthy. There was no variability indices of thyroid status in persons with analyzed immunogenetic systems of blood. This is consistent with data about the lack of clear communications thyroid dysfunction with various serological markers. Analysis of lipid metabolism and thyroid status of residents in areas contaminated with radionuclides showed no variation depending on the analyzed genetic factors. This feature was observed before and during emotional stress. At the same time, the patients who had undergone a prolonged effect of low doses of ionizing radiation, regardless of immunogenetic phenotype had significantly higher level of total cholesterol, triglycerides, HDL and LDL cholesterol as compared with controls. LDL cholesterol level is above the limit of homeostatic regulations and significantly increases during emotional stress. Emotional stress also leads to a significant increase (with going above the limit of normal) of total cholesterol and reduction of HDL cholesterol. Thus, immunogenetic erythrocytic system AB0 and Rhesus, and serum haptoglobin system take part in controlling lipid metabolism and have almost no effect on thyroid status. People who long lived in the areas contaminated with radionuclides, analyzed blood immunogenetic factors possibility is levelled in the regulation of lipid metabolism. This proves a violation of regulatory adaptive capacities with chronic exposure of low doses of ionizing radiation. Changes in the concentration of certain lipid fractions from going beyond the limits of homeostatic regulations make inhabitants of the strengthened radiation monitoring territory to be the risk group of the lipid metabolism violation with possible underlying cardiovascular diseases.