The role of secreting function of decidua in the development of complications of gestation process in pregnant women with a past history of chronic endometritis

Abstract

The aim: TodeterminetheserumFAMG in theIandII trimesterofpregnancyinwomenwith apast historyofchronicendometritis, andtoclarifyitsimpacton the development of pathology of pregnancy. Materials and methods: The level of FAMG was determined at 6-8 and 16-18 weeks of gestation in 135 pregnant women with a past history of chronic endometritis, who received treatment of chronic endometritis at the stage of pregravid preparation and 168 women who became pregnant without its prior treatment. The dependence of the development of pre-eclampsia on the level of FAMG at the early stages of pregnancy has been evaluated. Results: At 6-8 weeks of pregnancy, the level of FAMG in women with a past history of chronicendometritis was 20.6% lower (122.4 ± 7.6 ng/ml) compared to the control group. In FAMG of 90.3 ± 4.3 ng/ml at 6-8 weeks of gestation, spontaneous abortion occurred in 100% of cases within the next 2 weeks. FAMG lower than 122,1 ± 3,0 ng/ml can be the predisposing factor for the development of pre-eclampsia. Conclusions: Reduced FAMG in thebeginning of pregnancy in women with untreatedchronicendometritis in the past history increases theincidenceof miscarriagesat the earlystages by 2.6 times, andby 1.8 times theprobabilityofpreeclampsiadevelopment. Treatmentofchronicendometritis at thestage of pregravidpreparation promotes the increaseof FAMG by 24,6% compared to untreated women that reduces theprobabilityof complications during the subsequent course of pregnancy.