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Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.author | Zelinka-Khobzey, Marta M. | - |
dc.contributor.author | Tarasenko, Kostiantyn V. | - |
dc.contributor.author | Mamontova, Tetiana V. | - |
dc.contributor.author | Зелінка-Хобзей, Марта Миколаївна | - |
dc.contributor.author | Тарасенко, Костянтин Володимирович | - |
dc.contributor.author | Мамонтова, Тетяна Василівна | - |
dc.date.accessioned | 2021-12-28T07:57:43Z | - |
dc.date.available | 2021-12-28T07:57:43Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.citation | Zelinka-Khobzey M. M. Assessment of endothelial dysfunction in pregnant women with obesity and preeclampsia / M. M. Zelinka-Khobzey, K. V. Tarasenko, T. V. Mamontova // Wiadomości Lekarskie. – 2021. – Vol. 74, issue 8. – Р. 1905–1999. | uk_UA |
dc.identifier.uri | http://repository.pdmu.edu.ua/handle/123456789/17324 | - |
dc.description.abstract | The aim: to study the peculiarities of CD68+ and CD163+ macrophage expression in the placentas of women with obesity who developed preeclampsia by applying immunohistochemical method. Materials and methods: The study included 20 placentas taken from women who delivered full-term live-birth babies. The women were divided into 4 groups of 5 individuals each: women with physiological body weight (1st group); women with class II obesity (2nd group); women with physiological body weight and preeclampsia (3rd group); women with class II obesity, who developed preeclampsia (4th group). Results: The analysis of the expression level of CD68+ and CD163+ decidual macrophages shows the predominance of CD68+ pro-inflammatory profile over CD163+ anti-inflammatory profile in women of all groups. Evaluation of CD68+ and CD163+ expression levels of Kashchenko-Hofbauer cells in the stroma of the terminal villi of the placenta shows that the expression level of CD68+ macrophages is significantly higher in women with obesity and preeclampsia than in the control, or in women with obesity or preeclampsia. There was a reverse tendency to the polarization shift in Kashchenko-Hoffbauer cells in the stroma of the terminal villi towards the predominance of CD163+ macrophages over CD68+ macrophages in all groups of women. Conclusions: The imbalance in anti-inflammatory and pro-inflammatory profile of placental macrophages with a predominance of the latter can lead to the development of preeclampsia. | uk_UA |
dc.language.iso | en | uk_UA |
dc.publisher | Aluna Publishing | uk_UA |
dc.subject | preeclampsia | uk_UA |
dc.subject | pregnancy | uk_UA |
dc.subject | M1 and M2 macrophages | uk_UA |
dc.subject | obesity | uk_UA |
dc.title | Characteristics of CD68+ and CD163+ expression in placenta of women with preeclampsia and obesity | uk_UA |
dc.type | Article | uk_UA |
dc.identifier.doi | 10.36740/WLek202108122 | - |
Розташовується у зібраннях: | Наукові праці. Кафедра акушерства і гінекології № 1 Наукові праці. Кафедра фізіології |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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WLek202108122.pdf | 829,8 kB | Adobe PDF | Переглянути/Відкрити |
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