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Title: | Characteristics of CD68+ and CD163+ expression in placenta of women with preeclampsia and obesity |
Authors: | Zelinka-Khobzey, Marta M. Tarasenko, Kostiantyn V. Mamontova, Tetiana V. Зелінка-Хобзей, Марта Миколаївна Тарасенко, Костянтин Володимирович Мамонтова, Тетяна Василівна |
Issue Date: | Aug-2021 |
Publisher: | Aluna Publishing |
Citation: | Zelinka-Khobzey M. M. Assessment of endothelial dysfunction in pregnant women with obesity and preeclampsia / M. M. Zelinka-Khobzey, K. V. Tarasenko, T. V. Mamontova // Wiadomości Lekarskie. – 2021. – Vol. 74, issue 8. – Р. 1905–1999. |
Abstract: | The aim: to study the peculiarities of CD68+ and CD163+ macrophage expression in the placentas of women with obesity who developed preeclampsia by applying immunohistochemical method. Materials and methods: The study included 20 placentas taken from women who delivered full-term live-birth babies. The women were divided into 4 groups of 5 individuals each: women with physiological body weight (1st group); women with class II obesity (2nd group); women with physiological body weight and preeclampsia (3rd group); women with class II obesity, who developed preeclampsia (4th group). Results: The analysis of the expression level of CD68+ and CD163+ decidual macrophages shows the predominance of CD68+ pro-inflammatory profile over CD163+ anti-inflammatory profile in women of all groups. Evaluation of CD68+ and CD163+ expression levels of Kashchenko-Hofbauer cells in the stroma of the terminal villi of the placenta shows that the expression level of CD68+ macrophages is significantly higher in women with obesity and preeclampsia than in the control, or in women with obesity or preeclampsia. There was a reverse tendency to the polarization shift in Kashchenko-Hoffbauer cells in the stroma of the terminal villi towards the predominance of CD163+ macrophages over CD68+ macrophages in all groups of women. Conclusions: The imbalance in anti-inflammatory and pro-inflammatory profile of placental macrophages with a predominance of the latter can lead to the development of preeclampsia. |
Keywords: | preeclampsia pregnancy M1 and M2 macrophages obesity |
DOI: | 10.36740/WLek202108122 |
URI: | http://repository.pdmu.edu.ua/handle/123456789/17324 |
Appears in Collections: | Наукові праці. Кафедра акушерства і гінекології № 1 Наукові праці. Кафедра фізіології |
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