Кількісні характеристики антибактеріальної та антифунгіцидної дії наночастинок срібла у поєднанні з різними препаратами.

Abstract

В даній статті представлені дослідженні щодо впливу рідкого дисперсного розчину наночастинок срібла в поєднанні з 2-етил-6-метил-3-гідроксипіридину сукцинатом та полівініпіролідоном на музейні штами S. aureus, S. epidermidis, E. Coli та C.albicans у порівнянні з розчином наночастинок срібла, диспергованим у дистильованій воді. Встановлено, що дана композиція речовин володіє вираженими антибактеріальними властивостями, пригнічуючи ріст досліджуваних культур, особливо чутливими з яких виявилися E. Coli та C.albicans; В данной статье представлены результаты о влиянии жидкого дисперсного раствора наночастичек серебра в сочетании с 2-этил-6-метил-3-гидроксипиридина сукцинатом и поливинипиролидоном на музейне штамы S. aureus, S. epidermidis, E. Coli та C.albicans в сравнении с раствором наночастичек серебра, диспергированных в дистиллированной воде. Установлено, что данная композиция веществ обладает выраженными антибактеиальными свойствами, угнетая рост исследуемых культур, особенно чувствительными среди которых оказались E. Coli та C.albicans; It's known that silver has antibacterial properties and it is widely used in medicine. Nowadays different combinations of silver with polymers, which it is colloid systems, are used more often. That’s why there are very perspective macromolecular compounds, which can stabilize silver nanoparticles in the solution such as 2-ethyl-6-methyl-3-hidroksypirydyn succinate (mexidol) and low molecular weight PVP. Using of silver nanoparticles with them allows to lower the concentration of metal and in the same time to increase their antibacterial effect. It is proved that silver has the more strongly marked antimicrobial properties than some antibiotics such us penicillin, biomitsin and others. During these experiments we worked on the museum strains of S. aureus, S. epidermidis, E. Coli and C.albicans for finding of their sensitivity to different solutions of silver nanoparticles. So, the complex of the mexidol, 6%PVP and silver was used for that. As well the 0,05% Chlorhexidine Bigluconate was used as the control solution for the comparison. The sensitivity of microorganisms was found by the standard dilution method, according to the order of Ministry of Health. According to the results all museum strains of microorganisms, which were examined, had been sensible to solutions that were used. Although the complex of silver nanoparticles with distilled water has had antibacterial effect it has induced the less oppression of bacteria’s growing than other solutions. In spite of that fact that the combination of silver nanoparticles with the mexidol and 6%PVP has been less active than comparison solution it restrained the growing of all examined strains. It is very interesting that this combination has had the higher antibacterial property in several time than the first one. The most sensible museum strains to the solution of silver nanoparticles with the mexidol and 6%PVP were E. Coli and C.albicans. Summarizing all mentioned above we could make the conclusion that the using of silver nanoparticles as an antibacterialagent in medicine is perspective enough. In addition, 2-ethyl-6-methyl-3-hidroksypirydyn succinate (mexidol) and low molecular weight PVP can intensify the antimicrobial effect of silver nanoparticles.