Report on the study of spatial organization of the human prostate glands

Abstract

ABSTRACT Introduction: In terms of the spatial organization human prostate is the complex organ due to the fact that it consists of several types of glands, localized in several histotopographic areas, characterized by the heterogeneous structure. On the other hand, most of the prostate glands are characterized by the high degree of adjacency to each other and quite complicated architectonics of both the external and internal contours of their acini and terminal ducts. The aim: The paper was aimed at the study of steromorphological features of the tubuloalveolar secretory elements in the peripheral area of the human prostate. Material and Methods: 10 isolated postmortem specimens of the prostate gland, urinary bladder, seminal vesicles, fragments of the seminal ducts and urinary tracts which were taken from adult patients, died for the reasons not associated with the pathology of the urogenital system, have been analyzed to study the features of spatial organization of the human prostate glands in its peripheral area. To analyze the secretory components of the prostate stereological and decomposition methods have been used, which allow visualization of its structural and functional elements in all three inter-perpendicular planes. Results and Conclusions: The use of the suggested method enables to get the megascopic reconstruction of the acini and terminal ducts of the prostate gland which can be studied from all sides, getting a comprehensive idea about the shape and size, as well as allows to explore the inner topography of the organ’s structure, the geometry of the lumen of the epithelial excretory ducts, to determine the changes in the thickness of the wall, to get a visual representation of microtopographic correlation between the different parts of blood microcirculatory flow with the acini and terminal ducts of the prostate gland