2023
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Перегляд 2023 за Автор "Baliuk, O. Ye."
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Документ Oxidative stress: classic doctrine and its update(Полтавський державний медичний університет, 2023) Vazhnichaya, E. M.; Baliuk, O. Ye.; Bobrova, N. O.; Важнича, Олена Митрофанівна; Балюк, Олена Євгенівна; Боброва, Нелля ОлександрівнаThe concept of oxidative stress is widely used to describe damage caused by reactive oxygen and nitrogen species. This concept is actively developing and is the basis for the rational use of antioxidants. The purpose of the work is to analyze the literature data on the development of the doctrine of oxidative stress and its role in normal and pathological conditions. Literary sources were searched in PubMed and Google Scholar databases and the sources analyzed in this work were selected. The founders of the doctrine of oxidative stress have described that it can be a result of not only external factors, but also internal cellular mechanisms. This condition is characterized by the generation of reactive forms of oxygen and nitrogen in the cell, changes in antioxidant protection, oxidative modification of macromolecules and impaired redox balance. An important discovery was the fact that redox reactions are used in the cell signaling. Oxidative stress was detected in physiological conditions and involved in many diseases as their cause or consequence. The development of the oxidative stress doctrine relates to the improvement of strategies for its detection and quantitative evaluation, so the previously used indicators are supplemented with new ones, a comprehensive approach based on indices is introduced. It is believed that intense oxidative stress should be diagnosed to prevent the development of free-radical pathology and premature aging in a timely manner. Understanding of oxidative stress developed to the idea of oxidant-antioxidant equilibrium and the need for its normal slight shift to the side of oxidative processes to maintain homeostasis. This approach warns against excessive administration of exogenous antioxidants, which can disrupt the balance.