Вісник проблем біології і медицини, 2023, Випуск 3 (170)

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https://repository.pdmu.edu.ua/handle/123456789/21800

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Перегляд Вісник проблем біології і медицини, 2023, Випуск 3 (170) за Автор "Delva, M. Yu."

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    Features of the nociceptive flexor reflex in neuropathic dysesthetic pain in patients with multiple sclerosis
    (Полтавський державний медичний університет, 2023) Delva, M. Yu.; Skoryk, K. S.; Kryvchun, A. M.; Дельва, Михайло Юрійович; Скорик, Катерина Сергіївна; Кривчун, Анжеліна Михайлівна
    Neuropathic dysesthetic pain (NDP) is the most common type of neuropathic pain seen in patients with multiple sclerosis (MS). The study aims to determine the characteristics of the nociceptive flexor reflex (NFR) at the onset and features of the course of NDP in patients with MS. Two hundred forty-one patients with MS were included in the prospective study. Each patient received the PainDETECT questionnaire and was instructed on the rules for filling it out. In cases of diagnosis of NDP (according to the PainDETECT questionnaire >18 points), patients were invited to the clinic for an initial examination of NFR, which tentatively corresponded to the debut of NDP. A repeated study of NFR was carried out after 1 month. Patients who reported NDP during the 1-month study were invited to the next 3-month NFR study. As a control, an NFR study was conducted in 10 MS patients who had no pain during the last month. The neurophysiological study was performed using the Neurosoft MVP-2 electroneuromyography. Among patients with MS, NDP was associated with a significant decrease in NFR pain threshold and NFR threshold compared with patients without pain. The course of NDP was accompanied by a further decrease in NFR pain and NFR threshold at 1 and 3 months compared to the initial value. In addition, at the 3-month follow-up, patients with NDP still present had a significant reduction in NFR threshold compared with patients without NDP at that time. A decrease in the NFR threshold of 20% or more 1 month after the onset of NDP appeared to be a reliable prognostic marker of future NDP chronicity.