Вісник проблем біології і медицини, Випуск 3 (170)
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Перегляд Вісник проблем біології і медицини, Випуск 3 (170) за Автор "Dubyna, S. O."
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Документ Typical morphological characteristics of the skin structure of the hair part of the normal human head and with hair loss(Полтавський державний медичний університет, 2023) Tykhonova, O. O.; Sherstyuk, O. O.; Tarasenko, Ya. A.; Bilash, V. P.; Serbin, S. I.; Dubyna, S. O.; Tkachenko, O. T.; Тихонова, Олеся Олександрівна; Шерстюк, Олег Олексійович; Тарасенко, Яна Альбертівна; Білаш, Валентина Павлівна; Сербін, Сергій Ігорович; Дубина, Сергій Олександрович; Ткаченко, Олексій ТарасовичThe aim of our research was to reveal the peculiarities of the structural organization of the skin of the scalp of men in normal conditions and the nature of its restructuring in the process of androgenic hair loss. Object and research methods. To achieve the goal, we used a set of methods for morphological studies: methods of epoxy plastination of large pieces of skin; production of lamellar polished cuts and their coloring with methylene blue; their study using a binocular magnifier and a light microscope in reflected and transmitted light. Research results and theis discussion. New data were obtained, which expand and deepen modern ideas about the structure of the skin of the hairy part of the human head and the nature of its reconstruction during baldness. It has been shown for the first time that in the process of androgenic hair loss, intradermal hair follicles are primarily affected by degradation. This process is accompanied by the formation of aggregated hair follicles. Complete loss of hair in androgenic alopecia leads to a compensatory and adaptive restructuring of the skin of the scalp, which is expressed by the replacement of loose connective tissue in the hypodermis with adipose tissue, the growth of blood vessels in all the layers of the skin, among which venous ones prevail, as well as in the increase in the concentration of sebaceous glands in the retina layers of the dermis. It has been proven that despite the complete loss of hair in androgenic alopecia, germinal epithelial elements are present in the scalp skin, which are the source of the formation of thin (abortive) hair, the matrix structures of which are hidden in the thickness of the sebaceous glands. Conclusions. The obtained results not only supplement the known facts, but also more deeply reveal the principles of the morphological structure of the skin of the scalp of men in normal conditions and after androgenetic alopecia. On the basis of the received factual data, the position is substantiated, according to which hair loss in androgenic alopecia does not lead to pathological changes in the skin, but is compensated by the physiological hypertrophy of its other tissue components.