Проблеми екології та медицини. 2018

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https://repository.pdmu.edu.ua/handle/123456789/10557

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Перегляд Проблеми екології та медицини. 2018 за Автор "Izmailova, O. V."

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    Natural peptide complexes of thymus and kidneys reinforce apoptosis of transformed T-cells, but do not affect the processes of apoptosis in B-cells
    (Полтавський державний медичний університет, 2018) Shlykova, O. A.; Izmailova, O. V.; Lysanets, Yu. V.; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга Віталіївна; Лисанець, Юлія Валеріївна
    One of the most important issues in modern medicine is the search for methods for regulating programmed cell death in order to develop new approaches to treatment, including cancer and leukemia. Humoral regulation of theprocesses of apoptosis with the help of cytokines, hormones, growth factors, peptides plays an important role in the mechanisms of regulation of apoptosis. The effect of natural peptide complexes of thymus and kidneys on HPB-ALL (acute T-cell leukemia) and BJAB (Berkita lymphoma) cell apoptosis processes has been studied. It has been shown that the natural peptide complexes of the thymus and the kidneys have little stimulating effect on the apoptosis of BJAB tumor B cells at low concentrations, and when increasing the dose of peptides, they do not affect the processes of apoptosis; it is believed that the processes of elimination of transformed T-cells are enhanced by activating apoptosis processes in them. With the action of the natural peptide complex of thymus, this effect has a dose-dependent nature - increases with raising the dose.
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    Subcutaneous adipose tissue in female patients with iron deficiency anemia and obese women does not differ in the expression of ikbα
    (Полтавський державний медичний університет, 2018) Nedoborenko, V. M.; Shlykova, O. A. ; Izmailova, O. V.; Ishcheikin, K. E.; Kaidashev, I. P.; Недоборенко, Вадим Михайлович; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга Віталіївна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович
    Prerequisites and objective: Abdominal obesity is a common metabolic disease characterized by excessive accumulation of white adipose tissue, with excessive production of inflammatory mediators that activate transcriptional nuclear factors, in particular the nuclear factor kB. Hepcidin is the main hormone in the systemic regulation of iron. Its expression in- creases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. Therefore, the aim of the research was to determine the level of expression of ІКβα in subcutaneous adipose tissue in iron deficiency anemia concurrent with obesity. Meth- ods: The study included 40 female women. Hemogram parameters, parameters of iron metabolism (serum iron, ferritin, hepcidin, total iron binding ability of serum, saturation of transferrin by iron) in serum and level of expression of the IkBα gene in subcutaneous adipose tissue were evaluated. Research results. The examined women had an average age of 40.3 ± 7.59 years. In the distribution of patients due to the cause and degree of severity of IDA, there was no reliable difference between the groups. The control group consisted of 10 obese women without IDA. Expression of IkBα by sub- cutaneous adipose tissue in female patients with IDA with and without obesity compared with the control group did not display a significant difference between the groups (p <0.05). In the course of correlation analysis, the expression of IkBα by subcutaneous adipose tissue to BMI, iron and hemogram rates did not have a correlated significance. Conclu- sion. Subcutaneous adipose tissue in women with iron deficiency anemia with and without obesity compared with obese women has no difference in expression of IkBα.