Кафедра акушерства і гінекології № 1

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https://repository.pdmu.edu.ua/handle/123456789/6

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Перегляд Кафедра акушерства і гінекології № 1 за Автор "Boruta, N. V."

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    Complex histological and immunohistochemical study of monocytopoiesis in rats with determination of proliferative activity by expression Ki67 and CD68+ in the experiment
    (Полтавський державний медичний університет, 2021) Martynenko, R. V.; Shepitko, V. I.; Stetsuk, Ye. V.; Boruta, N. V.; Yakushko, O. S.; Martynenko, V. B.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Борута, Наталія Володимирівна; Якушко, Олена Святославівна; Мартиненко, Віталій Борисович
    Ki67 is not only one of the markers of proliferation, but also an indirect determinant of the rate of cell division. CD68 is exploited as a valuable cytochemical marker to immunostain monocyte/macrophages in the histochemical analysis of inflamed tissues, tumor tissues, and other immunohistopathological applications. The purpose of the study was to determine the cell proliferation index of the monocytic line of red bone marrow using antibodies to CD68+ and Ki-67 in the control and intact groups of animals. There were established an equivalent degree of proliferative activity by progenitor cells with Ki-67 expression in the control and intact groups.
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    Quantitative and qualitative changes in red bone marrow monocyte dipherone and microenvironmental cells during long-term triptorelin acetate administration in the experiment
    (Полтавський державний медичний університет, 2023) Martynenko, R. V.; Shepitko, V. I.; Pelypenko, L. B.; Boruta, N. V.; Martynenko, V. B.; Vilhova, O. V.; Stetsuk, Y. V.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Пелипенко, Лариса Борисівна; Борута, Наталія Володимирівна; Мартиненко, Віталій Борисович; Вільхова, Олена Вікторівна; Стецук, Євген Валерійович
    States. Huggins and Hodges demonstrated the therapeutic effect of testosterone deficiency in the gonads in the 1940s and thus confirmed the concept that prostate cancer is an androgen-dependent disease. Androgen deprivation therapy (ADT) is the main palliative treatment for men with locally advanced and metastatic prostate cancer, with the goal of reducing testosterone levels to the level obtained by surgical castration. The long-term chemical castration with triptorelin acetate leads to quantitative and qualitative changes in monocytic sprout cells at all levels of differentiation and proliferation with a complementary reaction of microenvironmental cells. The maximum quantitative changes in monocyte cells were observed at the 3rd month of the study, followed by a gradual recovery to the control group. Changes in the microenvironment cells: macrophages and reticular cells, were characterized by a stable reaction in the early stages of the study in the form of a decrease in the number and ratio of NSCs, with subsequent recovery of quantitative and qualitative changes to the level of the control group of animals. The adipocyte reacts at all stages of the study with a steady increase in quantitative and qualitative characteristics.