Проблеми екології та медицини. 2023

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https://repository.pdmu.edu.ua/handle/123456789/20831

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Перегляд Проблеми екології та медицини. 2023 за Автор "Cherniak, V. V."

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    Документ
    Acute myocardial infarction in a puerpera: a case report
    (Полтавський державний медичний університет, 2023) Fylenko, B. M.; Roiko, N. V.; Khazanov, O. P.; Romaniuk, A. М.; Cherniak, V. V.; Филенко, Борис Миколайович; Ройко, Наталія Віталіївна; Хазанов, Олександр Павлович; Романюк, Анатолій Миколайович; Черняк, Валентина Володимирівна
    We report a lethal case of acute myocardial infarction in a puerpera. Cardiovascular diseases rank as the leading causes of mortality during pregnancy and the postpartum period, with myocardial infarction (MI) being a rare yet frequently fatal occurrence. Research indicates that MI typically manifests between 6 to 12 weeks postpartum, though instances may also occur at later stages. The reported case is interesting in terms of the mismatch between the timing of clinical symptoms of acute coronary syndrome (less than 24 hours) in the puerpera and alterations in myocardial infarction (2-3 days), which was diagnosed morphologically. Therefore, we searched for possible causes that led to the clinical and morphological changes described above. At first glance, the main cause of myocardial infarction development is coronary artery dissection with the formation of hematoma in the wall of the blood vessel, which narrows its lumen and leads to necrosis of the heart muscle. A brief analysis of the case has established that ischemic damage to the myocardium preceded the development of spontaneous coronary artery dissection and could be caused by one of the factors or a combination of them: coronary artery spasm caused by ergometrine and anemia due to uterine atony-related postpartum hemorrhage. The formation of intramural hematoma of the vascular wall, which narrowed the lumen of the coronary artery, could be the result of the prescription of antithrombotic therapy, which complicated the health status of the woman and led to death. When providing medical care to puerperas with postpartum hemorrhage, it is necessary to take into account the risk for cardiovascular complications that could develop due to anemia or administration of ergometrine.
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    Документ
    The relationship of breast cancer, biomineralization disorders and bone metastases: a bibliographical analysis
    (Полтавський державний медичний університет, 2023) Starchenko, I. I. ; Korobchanska, A. B.; Fylenko, B. M.; Roiko, N. V.; Cherniak, V. V.; Старченко, Іван Іванович; Коробчанська, Анна Борисівна; Филенко, Борис Миколайович; Ройко, Наталія Віталіївна; Черняк, Валентина Володимирівна
    Bone metastases are the most common and hard-to-treat complication of BC. About 70% of patients with metastatic BC have distant bone relapses during the disease. BC always leads to the death of patients within 5-10 years, and this statistic has not changed in the last 2-3 decades. The work aims to carry out a bibliometric analysis of the interrelationships of BC, processes of biomineralization (calcification), and metastases of BC to bone tissue. The authors searched electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar for the period 1973-2023 using key terms such as "breast cancer," "calcification," and "bone metastases." For bibliometric analysis, an online platform for monitoring and analyzing international scientific research using visualization tools and current citation metrics SciVal (Scopus), and a tool for building and visualizing bibliometric networks VOSviewer, were used. The authors used Scopus database bibliometric tools to analyze the year, source, type of study, subject area, and country of the publication. The VOSviewer system from the University of Leiden (https://www.vosviewer.com/download) was used to generate and visualize the bibliometric network. We found and examined 103 publications in the Scopus database using the keywords "breast cancer," "calcification," and "bone metastases" for the period 1973-2023. The results of the bibliometric analysis indicate that the number of publications on the specified subject has grown significantly (with small fluctuations) over the past 20 years, indicating scientists' interest in the problem and ways to solve it. The complex relationship between pathological biomineralization, breast cancer, and bone metastases is being actively studied by scientists, mainly from the United States of America, Germany, and Italy. Using the tool for building and visualizing bibliometric networks VOSviewer of publication activity for the period 1973-2023 in the researched topics of BC with calcification, we identified four chronological stages, which include: 1) radiological and biochemical research methods, 2) research on the effectiveness of diagnostics and treatment, including .h pathomorphological assessment of pathology, 3) fundamental studies of bone and mineral metabolism, 4) a practically oriented period of research. We also divided the identified publications into six thematic clusters: 1) application of radiological methods, 2) bone and mineral metabolism in conditions of pathology, 3) clinical diagnosis and prediction of the course of related pathology, 4) biomaterials and nanotechnology, 5) chemotherapy of oncopathology and its consequences, 6) fundamental molecular genetic research.