Перегляд за Автор "Avramenko, Ya."

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    Innovative issues of improving the quality of the educational process
    (Полтавський державний медичний університет, 2023) Digtiar, N.; Gerasimenko, N.; Lavrenko, А.; Avramenko, Ya.; Дігтяр, Наталія Іванівна; Герасименко, Наталія Дмитрівна; Лавренко, Анна Володимирівна; Авраменко, Яніна Миколаївна
    In today's conditions of an ever-increasing flow of information, which previously a person received throughout his life, modernization of the educational space is needed, based on innovative strategies using the latest achievements of science and practice. It is not so much necessary to transfer to students the amount of this or that knowledge, but to teach them to acquire this knowledge independently, to be able to navigate in the information space, to use the acquired knowledge, which in general contributes to the development of critical thinking and the formation of professional competences, which will be used in the future in the conditions of continuous self-education
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    Interleukin-26 is associated with the level of systemic inflammation and lung functions in obese and non-obese moderate-to-severe asthmatic patients
    (2022) Avramenko, Ya.; Izmailova, O. ; Shlykova, O.; Kaidashev, I.; Авраменко, Яніна Миколаївна; Ізмайлова, Ольга Віталіївна; Шликова, Оксана Анатоліївна; Кайдашев, Ігор Петрович
    Introduction: Obese asthma is a complex syndrome, which includes different phenotypes of disease. At present, these phenotypes only have started to acquire a suffcient understanding. It was suggested that IL-26 is a potential biomarker of disease severity in asthma without signs of Th2-mediated infammation. In this study, we investigated the serum and exhaled levels of IL-26 and its associations with the level of systemic infammation, lung functions, and body weight in obese and non-obese moderate-to-severe asthmatic patients Material and methods: The study included 10 healthy subjects, 10 obese subjects without lung pathologies, 10 non-obese asthmatics (NOA) (BMI 18.5–24.9 kg/m2 ), and 40 obese asthmatics (OA) (BMI 25.0–49.9 kg/m2 ). During the visit, patients’ examination and spirometry with the bronchodilator reversibility test were conducted, the exhaled breath condensate (EBC) was obtained, and the blood samples were collected. The level of IL-26, interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6), TNF-α, interleukin-10 (IL-10), total and specifc immunoglobulin E (IgE), and high sensitive C reactiveprotein (hs-CRP) were measured using the ELISA kits. Statistical comparison between 2 groups was analyzed using the Mann–Whitney rank-sum test. Chi-square with Yates’ correction was used to compare frequencies. Spearman’s rank test was used for correlating nonparametric variables. The Receiver Operating Characteristic (ROC) curve and the area under ROC curve (AUC) were used for evaluating the diagnostic power of IL-26 as a possible biomarker. Results: NOA had a reversible airway obstruction with reduced FEV1, FEV1/FVC, FVC 25/75, and positive post-bronchodilator test (PBT), signifcantly increased serum levels of IL-10, IL-4, and slightly increased IL-26. NOA had signifcantly increased exhaled IL-26 in comparison with healthy subjects. The obese subjects had a normal ventilatory pattern without airway obstruction, and differences in serum IL-26, IL-10, and IL-4 concentrations in comparison with healthy subjects. Obese subjects had a signifcant escalation of hs-CRP and no differences in the levels of exhaled IL-26, IL-10, and hs-CRP as compared with healthy subjects. OA had reduced FEV1, FEV1/FVC, and FEV25–75 in comparison with non-obese asthmatics. OA had elevated IL-26, IL-10, IL-4, and hs-CRP concentrations as compared with healthy subjects. These patients had a partial similarity with both non-obese asthmatics (elevated IL-26, IL-10, and IL-4) and obese subjects (elevated, IL-1β, IL-6, TNF-α, hs-CRP). OA had a reduced concentration of exhaled IL-26 in comparison with NOA and elevated exhaled IL-10 in comparison with obese subjects. Furthermore, OA had an increased concentration of IL-1β and TNF-α in comparison with healthy individuals and NOA. Exhaled IL-26 concentration distin-guished non-obese asthmatics from healthy subjects, asthmatic patients from non-asthmatics (healthy and obese subjects), all asthmatic patients from non-asthmatics (healthy and obese subjects).Conclusions: Exhaled IL-26 elevated in obese and non-obese moderate-to-severe asthmatic patients. Exhaled IL-26 might be a perspective biomarker in non-obese and obese asthmatics. The obese asthmatic phenotype comprised the combined systemic and local airway infammation.
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    Modern aspects of the study of biomarkers in patients with diabetic kidney disease and type 2 diabetes
    (European Journal of Case Reports in Internal Medicine, 2023) Borzykh, O.; Mormol, I.; Lavrenko, A.; Avramenko, Ya.; Kaidashev, I. ; Борзих, Оксана Анатоліївна; Мормоль, Ірина Анатоліївна; Лавренко, Анна Володимирівна; Авраменко, Яніна Миколаївна; Кайдашев, Ігор Петрович
    The study was designed to evaluate the potential significance of the urine biomarkers for the early diagnosis and development of the personalized management plan for the patients with type 2 diabetes and associated kidney disease regardless of other complications.The study was designed to determine the significance of the modern serum and urine biomarkers for the diagnosis and development of the personalized management plan for the patients with type 2 diabetes and associated kidney disease. The initial data results confirm the importance of setting the new approaches to the early diagnosis and reasonable personalized treatment for patients with type 2 diabetes and cardio-vascular and renal complications, as this can work as an effective tool for the prevention of further complications and so the improvement of prognosis and the quality of life for such patients.
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    Ways to improve the management of patients with kidney disease and diabetes, taking into account the associated pathology
    (2021) Borzykh, O.; Lavrenko, A.; Avramenko, Ya.; Kaidashev, I. ; Борзих, Оксана Анатоліївна; Лавренко, Анна Володимирівна; Авраменко, Яніна Миколаївна; Кайдашев, Ігор Петрович