Перегляд за Автор "Baliuk, Olena"

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  • Ескіз недоступний
    Документ
    Systemic effect of the antioxidant gel in experimental dermatologic pathology
    (2024) Vazhnichaya, Elena; Baliuk, Olena; Sydorenko, Antonina; Важнича, Олена Митрофанівна; Балюк, Олена Євгеніївна; Сидоренко, Антоніна Григорівна
    Many dermatological diseases are accompanied by oxidative stress and natural antioxidants are used in dermatology and cosmetology. The efforts to use synthetic antioxidants for skin care and treatment are practically absent. That is why we select for this investigation new topical formulation of ethylmethylhydroxypyridine succinate (EMHPS), a synthetic antioxidant. The objective is to study the status of lipid peroxidation and antioxidant protection in the blood of animals with experimental dermatologic pathology under the influence of the EMHPS gel topical use. There were three series of experiments on 125 adults male Wistar rats with chemical depilation, acute ultraviolet skin damage and psoriatic-like dermatitis. The 5% EMHPS gel was applied to the skin in a dose of 125 mg/kg. The duration of treatment was 21 days after chemical depilation, 3 days after ultraviolet irradiation, and 6 days after the induction of imiquimod dermatitis. The animals were euthanized in different moments of the experiments and the malondialdehyde (MDA) concentration, superoxide dismutase (SOD) and catalase activities were determined in the blood. The data were statistically processed by ANOVA method with a post-hoc Tukey test.
  • Ескіз
    Документ
    The influence of topical antioxidant use on hair regrowth and skin condition after chemical depilation
    (Brazilian Society of Dermatology, 2025) Baliuk, Olena; Akimov, Oleh; Vazhnichaya, Elena; Kostenko, Vitalii; Starchenko, Ivan; Балюк, Олена Євгеніївна; Акімов, Олег Євгенович; Важнича, Олена Митрофанівна; Костенко, Віталій Олександрович; Старченко, Іван Іванович
    Introduction: Hair restoration treatments for alopecia using existing medications are not always effective, highlighting the need for new therapeutic options. Objective: This study aimed to evaluate the effects of a topical gel containing ethyl-methyl-hydroxypyridine succinate (EMHPS) on hair regrowth and biochemical and histological skin parameters in animals following chemical depilation. Methods: Experiments were conducted on 50 adult male Wistar rats. Alopecia was induced using a commercial depilatory product containing potassium thioglycolate. A 5% EMHPS gel (125 mg/kg) was applied daily to the depilated skin. Trichoscopy, biochemical analysis, and histological examination of skin samples were performed on days 3, 9, and 21 of treatment. Results: The EMHPS gel demonstrated a tendency to accelerate hair regrowth, reduce lipid peroxidation, normalize antioxidant enzyme activity, and restore hydroxyproline and glycosaminoglycan levels in the treated skin compared to the untreated pathology control. Conclusions: The EMHPS gel primarily influences skin biochemical parameters and may be beneficial for treating forms of alopecia associated with oxidative stress.