Перегляд за Автор "Berezniakov, V. I."
Зараз показуємо 1 - 2 з 2
Результатів на сторінці
Налаштування сортування
Документ Cytokines as mediators of the immune system and their role In the pathogenesis of community-acquired pneumonia(Полтавський державний медичний університет, 2021) Berezniakov, V. I.; Korzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Pyvovar, N. M.; Березняков, Владислав Ігорович; Корж, Олексій Миколайович; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Пивовар, Ніна МихайлівнаThe clinical and immunological examination of patients with community-acquired pneumonia has been carried out that included the study of the IL-2, IL-4, IL-6, IL-8 and TNFα cytokines’ system. Immune system disorders that determine the severity of pneumonia, the amount of inflammatory damage to the lung tissue, disrupted elimination of the immune complexes have been found. These tendencies to a decrease in the mmunoglobulins M and G result in a moderate course of community-acquired pneumonia and lobar lesions of the lungs, and the immune system disorders are reliably associated with imbalance of cytokines, with a predominance of their pro-inflammatory activity and a decrease in regulatory functions. The findings of the immunological monitoring indicate that standard antibiotic therapy in patients with community-acquired pneumonia leads to its clinical and radiological resolution, though it is not accompanied by the normalization of immunity parameters. The imbalance of the cytokine component of immunity justifies the need for further development of pathogenetic, as well as immunocorrective therapy, in patients with community-acquired pneumonia.Документ General description of patients with community-acquired pneumonia Who passed an open comparative study(Полтавський державний медичний університет, 2022) Berezniakov, V. I.; Кorzh, A. N.; Pavlov, S. B.; Yeroshenko, G. A.; Shevchenko, K. V.; Zvyagolska, І. М.; Sharlay, N. М.; Березняков, Владислав Ігорович; Корж, А. Н.; Павлов, Сергій Борисович; Єрошенко, Галина Анатоліївна; Шевченко, Костянтин Васильович; Звягольська, Ірина Миколаївна; Шарлай, Наталія МиколаївнаThe article provides a general description of the etiology and pathogenesis of patients with community-acquired pneumonia who passed an open comparative study at the Kharkiv Municipal Clinical Hospital No. 25. The most likely causative agents of community-acquired pneumonia in patients of the Therapeutic Department of the Kharkiv Municipal Clinical Hospital No 25 are Streptococcus pneumoniae and mixed cultures of bacteria, with an increase in the proportion of Staphylococcus aureus. In modern conditions, when choosing the tactics of antimicrobial therapy for community-acquired pneumonia, it is necessary to consider not only the spectrum of the most likely pathogens, but also the trends in the formation of antibiotic resistance in the leading etiological groups. It is impractical to prescribe empirical antibiotic therapy for community-acquired pneumonia without establishing an etiological diagnosis.