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Документ Influence of pallet rich plasma, quercetin and their combination on activity of nitric oxide cycle enzymes in nasal mucosa of patients with atrophic rhinitis(Aluna publishing, 2024-02-05) Bondarenko, Ruslan V.; Bezshapochnyy, Sergey B.; Bezega, Mychailo I.; Loburets, Valerii V.; Kostenko, Vitilii O.; Akimov, Oleh Ye.; Bilous, Alevtyna M.; Бондаренко, Руслан Валерійович; Безшапочний, Сергій Борисович; Безега, Михайло Іванович; Лобурець, Валерій Васильович; Костенко, Віталій Олександрович; Акімов, Олег Євгенович; Білоус, Алевтина МиколаївнаAim: To study the general activity of NO synthases (gNOS), the activity of inducible and constitutive isoforms of NO synthase, the activity of arginases, and theconcentration of nitrites in the nasal mucosa under the conditions of local treatment of chronic atrophic rhinitis (AR) with quercetin and platelet-rich plasma (PRP therapy). Materials and Methods: The study was conducted on 118 patients divided into two groups: control (n=20) and experimental (patients with AR, n=98). Experimental group was divided into 4 subgroups: standard treatment (n=29), PRP therapy (6 injections for 28 day course, n=19), Quercetin (40 mg 3 times a day for 28 days, n=26) and PRP+Quercetin (n=24) groups. Results: Standard therapy of SaR increases gNOS by 278.38% and arginase activity increases by 222.73%. PRP therapy increases gNOS by 211.43% and arginase by 540.91%. Quercetin elevates gNOS by 108.33% and arginase by 250%. PRP therapy and quercetin increases gNOS by 146.15% and arginase by 536.36%. Conclusions: The use of standard therapy of SaR and addition of PRP therapy, quercetin and their combination effectively restores the production of nitricoxide and the arginase activity in the nasal mucosa.Документ Mineralization of teeth enamel after eruption(ALUNA Publishing House, 2021) Kostyrenko, Oleksij P.; Vynnyk, Nataliia I.; Koptev, Mykhailo M.; Hasiuk, Petro A.; Skrypnyk, Maksym I.; Bilous, Alevtyna M.; Proskurnya, Serhii A.; Костиренко, Олексій Петрович; Винник, Наталія Іванівна; Коптев, Михайло Миколайович; Гасюк, Петро Анатолійович; Скрипник, Максим Ігорович; Білоус, Алевтина Миколаївна; Проскурня, Сергій АнатолійовичThe aim: The paper was aimed at the study of the processes of mineralization of the enamel of the permanent tooth after its eruption. Materials and methods: To study the structure of the enamel of permanent teeth has been carried out using light and electron microscopy. The study of the process of the development of the primordia of the permanent teeth involved 10 culled puppies of 30-40 days of age. Microscopic, electron microscopic, immunohistochemical methods of research have been used to study the processes of histogenesis. Results: The studies show that in the postnatal period, the formation of the crown, externally covered with cuticular epithelium, marks the formation of the primordium of the permanent tooth at the follicle stage. After eruption of a tooth, different parts of its crown have three individual structural and functional barriers to enamel biomineralization. The frst one is provided by the cuticular epithelium of the pitted areas of the crown, which ensures fltering of the salivary fluid from the protein deposit in the form of a pellicle. The second barrier is defned on the lateral and cuspidate surfaces of the enamel, where the cuticle is erased or poorly expressed. The third structural and functional barrier of enamel biomineralization is located in the cervical portion of teeth of different classes. Conclusions: Different areas of the enamel in the tooth crown have specifc fltration barriers, which can be distinguished as follows: pit-and-fssure-and-groove, cuspidateand-approximal, and cervical barriers. The cuticle is poorly expressed or totally absent on the cusps of the tooth crowns in contrast to pitted areas.