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7 кроків до відновлення після коронавірусної хвороби (COVID-19) : методичні рекомендації для пацієнтів
(ПП Пасинога О.М., 2021) Бойко, Дмитро Миколайович; Бойко, Оксана Сергіївна; Boiko, D. I.; Boiko, O. S.
Методичні рекомендації для пацієнтів розроблені на основі досвіду передових наукових практик. У них репрезентовані базові принципи поетапного відновлення після перенесеної коронавірусної хвороби (COVID-19) різного ступеня тяжкості.
A conception of integrated phased model combining sleep hygiene and stimulus control as an adult sleep education approach
(Frontiers, 2024-12-18) Shkodina, A. D.; Boiko, D. I.; Шкодіна, Анастасія Дмитрівна; Бойко, Дмитро Іванович
The prevalence of mental illnesses, particularly those associated with the impact of stress, is on the rise globally. Conditions like stress, depression, and anxiety are intricately connected to sleep and circadian rhythms through shared underlying mechanisms, underscoring the significance of sleep health as a critical public health concern. We recommend considering a structured approach to sleep hygiene and stimulus control education in future research to enhance consumer acceptance of this information. An integrated phase model may be beneficial to organize the training into different parts of the day to effectively guide the client through the advices. Specifically, the client can identify the specific time block in which they experience disturbances and concentrate on addressing it during therapy.
Affective syndromes in adults with chronic low back pain
(Medicinska Naklada Zagreb, 2023) Mats, O. V.; Kachala, V. V.; Kachur, R. V.; Boiko, D. I.; Zhyvotovska, L. V.; Мац, Оксана Василівна; Качала, Вероніка Володимирівна; Качур, Роман Володимирович; Бойко, Дмитро Іванович; Животовська, Лілія Валентинівна
Low back pain can have as organic or non-specific, as psychological etiology. It is known that psychological factors have some relationship with adjustment to persistent pain, that is factors leading to increased/worse or decreased/improved adjustment to back pain. We conducted a case-control study in the Communal Enterprise “1st City Clinical Hospital of the Poltava City Council” during October-January 2021. The study included 19 people with complaints of neuropathic pain in the lower back who were divided into 2 groups: group 1 included 18 people with neuropathic pain; group 2 included 21 people with nonspecific pain. Patients suffering from low back pain have different severity of affective symptoms depending on its type. Neuropathic pain may be associated with higher depression due to higher severity, which should be noted in the choosing of treatment approaches.
Alexithymia in healthy people and its role in development of different disorders
(Українська медична стоматологічна академія, 2019) Skrypnikov, A. M.; Zhyvotovska, L. V.; Herasymenko, L. O.; Boiko, D. I.; Bodnar, L. A.; Скрипніков, Андрій Миколайович; Животовська, Лілія Валентинівна; Герасименко, Лариса Олександрівна; Бойко, Дмитро Іванович; Боднар, Леся Анатоліївна
Знижену здатність або ускладненість усно висловити, назвати власні емоційні стани або почуття інших людей,прийнято називати алекситимією. В даний час проводяться дослідження, в яких з'ясовують, чи є алекситимія специфічною властивістю особистості або ж вона може призводити до психосоматичних захворювань, будучи їх предиктором. Деякі дослідники вважають, що алекситимія сама по собі не є захворюванням і являє собою ряд характеристик, властивих певним індивідам. Алекситимія чітко виражена в складі особистості пацієнтів із серцевосудинними захворюваннями і являє собою окремий фактор в цій структурі. В цілому дослідження показують, що пацієнти з алекситимією гіперчутливі як до внутрішніх соматичних неприємних відчуттів, так і до зовнішніх больових стимулів, проте описати відмінності різних видів болю у них не виходить. Алекситимію можна розглядати як один з преморбідних особистісних факторів, що знижують компенсаторні можливості психологічного захисту при люцидному алкоголізмі. Алекситимія виявлена у багатьох пацієнтів з наркоманіями. Замість того, щоб просто звільнитися від болісних, нестерпних або гнітючих почуттів, люди, які зловживають хімічними речовинами, можуть використовувати їх для управління афектами, особливо коли ці афекти виявляється важко вловити, розрізнити і дати їм назву. У той же час недостатньо вивчені відмінності в проявах алекситимії при алкогольних і наркотичних залежностях, в тому числі її вплив на розвиток залежної поведінки. Вивчення алекситимії є актуальним питанням сучасної психіатрії та наркології, оскільки дозволить застосовувати персоніфікований підхід до пацієнта та вдосконалити сучасні лікувально-реабілітаційні заходи.
Association between emotional-volitional dysfunction and features of aggression or hostility in mens with different forms of substance addictions: a cross-sectional study
(Aluna Publishing, 2020) Zhyvotovska, L. V.; Boiko, D. I.; Kadzhaia, N. V.; Shkodina, A. D.; Demianenko, I. V.; Borysenko, V. V.; Животовська, Лілія Валентинівна; Бойко, Дмитро Іванович; Шкодіна, Анастасія Дмитрівна; Борисенко, Володимир Васильович
The aim: The research aim was to study features of emotional-volitional sphere and its association in mens with different forms of Substance Addictions. Materials and methods: We examined 146 patients with alcohol and drug addictions using Toronto Alexithymia Scale, Zverkov-Eidmann`s questionnaire and Buss-Durkee questionnaire. Results: The study showed an increase in the overall level of alexithymia, a moderate level of aggressiveness and a sufficient level of volitional self-regulation without a significant difference between the groups. The indirect correlation of “persistence” with the “general level of alexithymia”, “difficulty identifying feelings” and “physical aggression” in group 1 and at the same time the indirect correlation between “self-control” and “verbal aggression” and “volitional self-regulation” with “difficulty describing feelings” can be explained by the opposite meaning of these concepts and phenomena themselves.However, it is interesting that the indicators “physical aggression” and “difficulty describing feelings” in group 2 were significantly lower, but at the same time correlated with “general level of alexithymia” and “irritability”, respectively. On other hand in group 1 the indicator “suspiciousness” is directly related to the “general level of alexithymia”, but its level is significantly lower in comparison with group 2. Conclusions: The phenomenon of alexithymia is not only recorded in the clinical picture of patients with various forms of addiction, but can also induce the development of manifestations of aggressiveness and hostility in them. Correction of alexithymia is necessary to understand the emotional state of these patients and choose the right approach to their treatment and rehabilitation.
Challenges and Gaps in the Treatment of Advanced Sleep Phase Disorder: A Call for Further Research and Understanding
(University of Niš, 2024) Boiko, D. I.; Mats, O. V.; Shkodina, A. D.; Skrypnikov, A. M.; Бойко, Дмитро Іванович; Мац, Оксана Василівна; Шкодіна, Анастасія Дмитрівна; Скрипніков, Андрій Миколайович
People with circadian rhythm disturbances are at an elevated risk of mental disorders, and conversely, those with mental disorders are more susceptible to the circadian disruption. A steady circadian cycle of sleep and wakefulness that is phase-shifted relative to the prior local solar time may be characterized by a short endogenous circadian period. Advanced sleep-wake phase disorder (ASPD) is characterized by a substantial advancement of the sleep-wake cycle phase, followed with sleep-related symptoms. ASPD is a challenging sleep-wake disorder to manage, with current treatment options varying in efficacy and potential side effects. Further research is needed to identify effective treatment options and to elucidate the underlying mechanisms of ASPD. More research is needed to better understand the underlying mechanisms of ASPD and the molecular and metabolic changes associated with aging that may contribute to the development of the disorder.
Circadian rhythm disorder and anxiety as mental health complications in post‑COVID‑19
(Springer, 2022) Boiko, D. I.; Skrypnikov, A. M.; Shkodina, A. D.; Hasan, M. M.; Ashraf, G. M.; Rahman, M. H.; Бойко, Дмитро Іванович; Скрипніков, Андрій Миколайович; Шкодіна, Анастасія Дмитрівна
In 2020, the world gained dramatic experience of the development of the 2019 coronavirus disease pandemic (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). Recent researches notice an increasing prevalence of anxiety and circadian rhythm disorders during COVID-19 pandemic. The aim of the study was describing clinical features of circadian rhythm disorders and the level of anxiety in persons who have had COVID-19. We have conducted a cohort retrospective study that included 278 patients who were divided into 2 study groups according to medical history: group 1 includes patients with a history of COVID-19; group 2 consists of patients who did not have clinically confrmed COVID-19 and are therefore considered not to have had this disease. To objectify circadian rhythm disorders, they were verifed in accordance with the criteria of the International Classifcation of Sleep Disorders-3. The level of anxiety was assessed by the State-Trait Anxiety Inventory. The most common circadian rhythm disorders were sleep phase shifts. We found that COVID-19 in the anamnesis caused a greater predisposition of patients to the development of circadian rhythm disorders, in particular delayed sleep phase disorder. In addition, it was found that after COVID-19 patients have increased levels of both trait and state anxiety. In our study, it was the frst time that relationships between post-COVID-19 anxiety and circadian rhythm disorders had been indicated. Circadian rhythm disorders are associated with increased trait and state anxiety, which may indicate additional ways to correct post-COVID mental disorders and their comorbidity with sleep disorders.
Clinical features of anxiety disorder in post-COVID-19 syndrome and finding of its predictors
(Національний університет ім. О. О. Богомольця, 2021-12-26) Boiko, D. I.; Бойко, Дмитро Іванович
The article summarizes and describes clinical features of anxiety disorders in post-COVID-19 syndrome. Mental and neurological disorders occupy a leading place in the structure of post-COVID syndrome. Recent studies indicate an increase in the incidence of anxiety disorders in individuals with COVID-19. However, no clini-cal or laboratory features of the post-COVID anxiety disorders have been identified. Therefore, our study aimed to describe the clinical features of anxiety disorders in the post-COVID period and to develop a mathematical prog-nostic model to identify potential predictors of post-COVID anxiety disorder. We conducted a case-control clinical study, which included 145 males and females, which were divided into 2 groups, namely: group 1 - patients who became ill with COVID-19 during the last 6 months and group 2 - persons who were not ill with COVID-19 during the last 6 months. The clinical interview included the registration of symptoms of the debut and the time of the debut relative to the episode of COVID-19. The Beck anxiety inventory was used for the assessment of the overall level of anxiety. The State-trait anxiety inventory was used to assess state and trait anxiety. Statistical analysis of the data was performed using the program EZR Statistics 1.54. Anxiety disorders during the first 6 months after COVID-19 develop more often than those who have not had the disease in the last six months. Patients who had COVID-19 in the last 5-24 weeks have an increased risk of anxiety disorders during this period and therefore require close medical supervision and sufficient awareness of the likely symptoms. People with a post-COVID anxiety disorder reported the presence of autonomic symptoms, including excessive sweating and tachycardia, a feeling of inner emptiness, as well as circadian rhythm disorders in the form of difficulty falling asleep and waking up at the desired time. It should be noted that the overall frequency of detection of anxiety disorders in the post-COVID period is increasing. It has been established that the risk of developing post-COVID disorder decreases with knowledge of the fact of contact with an infected person before the COVID onset and increases with a heightened level of prior personal anxiety. Circadian rhythm disorders, in particular sleep phase shift and abnormal fatigue, may be predic-tors of post-COVID anxiety disorder.
Cognitive and affective disturbances in patients with Parkinson's disease: Perspectives for classifying of motor/neuropsychiatric subtypes
(Elsevier, 2022-06) Shkodina, A. D.; Tarianyk, K. A.; Boiko, D. I.; Zehravi, Mehrukh; Akter, Shamima; Ashraf, Ghulam Md.; Rahman, Md. Habibur; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро Іванович
Parkinson’s disease (PD) is a neurological disorder, related to rigidity, bradykinesia, and resting tremors, among other motor symptoms. It is noticed in the increasing frequency of neuropsychiatric disorders, which may be also caused by non-motor symptoms of PD. Treatment of PD is usually based on the classification of motor subtypes; however, it remains unclear whether motor subtypes have differences in the severity of psychiatric symptoms. It determines the importance of discovering possible neuropsychiatric subtypes of PD. We conducted a clinical study, which included group 1 - patients with postural instability and gait disorders dominant (PIGD) subtype, group 2 - patients with tremor dominant (TD) and indeterminate subtypes (non-PIGD), and group 3 - people who did not have CNS damage. We used the Montreal Cognitive Assessment, Russified 20-point version of the Toronto Alexithymia Scale, State-Trait Anxiety Inventory, and Beck Depression Inventory for assessment of the mental status. It was the first time that neuropsychiatric subtypes of PD had been investigated based on the condition of cognition and mood. Cluster analysis gave us the possibility to classify our patients by the following subtype: affective-cognitive PIGD, anxious PIGD, affective-cognitive non-PIGD, and non-PIGD without psychiatric symptoms. This indicates a closed link between psychiatric and motor symptoms, which can be used for the improved treatment of PD.
Drug reprofiling history and potential therapies against Parkinson’s disease
(2022-10-26) Latif, Komal; Ullah, Aman; Shkodina, A. D.; Boiko, D. I.; Rafique, Zakia; Alghamdi, Badrah S.; Alfaleh, Mohamed A.; Ashraf, Ghulam Md.; Шкодіна, Анастасія Дмитрівна; Бойко, Дмитро Іванович
Given the high whittling down rates, high costs, and moderate pace of new medication, revelation, and improvement, repurposing “old” drugs to treat typical and uncommon illnesses is progressively becoming an appealing proposition. Drug repurposing is the way toward utilizing existing medications in treating diseases other than the purposes they were initially designed for. Faced with scientific and economic challenges, the prospect of discovering new medication indications is enticing to the pharmaceutical sector. Medication repurposing can be used at various stages of drug development, although it has shown to be most promising when the drug has previously been tested for safety. We describe strategies of drug repurposing for Parkinson’s disease, which is a neurodegenerative condition that primarily affects dopaminergic neurons in the substantia nigra. We also discuss the obstacles faced by the repurposing community and suggest new approaches to solve these challenges so that medicine repurposing can reach its full potential.
Healthcare system amidst the war in Ukraine
(Elsevier, 2022) Shkodina, A. D.; Chopra, H.; Singh, I.; Shoaib, A.; Boiko, D. I.
For more than two months now, Russian troops have been destroying cities in Ukraine. On February 24, 2022, Russia unreasonably attacked Ukraine. The bloody conflict in Ukraine has seen several attacks on healthcare institutions, including hospitals and clinics. Healthcare is a significant force, especially in the context of military conflict. Not only because it takes care of wounded combatants, but also because it allows the society to continue to function before, during, and after the war. The healthcare system in Ukraine is facing the terrible challenges of war and needs humanitarian aid and the support of the international community.
Increased subsequent risk of mental disorders after experienced stress-related disorders: correspondence
(Elsevier, 2023) Boiko, D. I.; Shkodina, A. D.; Бойко, Дмитро Іванович; Шкодіна, Анастасія Дмитрівна
Based on multiple studies, we emphasize isolated findings regarding the long-term implications of stress-related mental diseases, particularly alterations in the neurological, immunological, and endocrine systems’ homeostasis, as well as an increased risk of occurring other psychiatric disorders. Thus, despite substantial theoretical evidence, the mechanism and duration of alterations caused by stress-related disorders remain unexplained. Because the number of factors that can act as traumatic factors and lead to the development of stress-related disorders is increasing in the modern world, we should pay attention not only to the relief of acute symptoms of the disease but also to the evaluation of its prognosis and long-term consequences for improving global health.
Melatonergic Receptors (Mt1/Mt2) as a Potential Additional Target of Novel Drugs for Depression
(Springer, 2022-06) Boiko, D. I.; Shkodina, A. D.; Hasan, Mohammad Mehedi; Bardhan, Mainak; Kazmi, Syeda Kanza; Chopra, Hitesh; Bhutra, Prerna; Baig, Atif Amin; Skrypnikov, A. M.; Бойко, Дмитро Іванович; Шкодіна, Анастасія Дмитрівна; Скрипніков, Андрій Миколайович
A complex pathogenesis involving several physiological systems is theorized to underline the development of depressive disorders. Depression is accompanied by circadian regulation disruption and interaction with the functioning of both central and peripheral oscillators. Many aspects of melatonin function unite these systems. The use of drugs for circadian rhythm disorders could inspire a potential treatment strategy for depression. Melatonin plays an essential role in the regulation of circadian rhythms. It exerts effect by activating two types of melatonin receptors, type 1A (MT1) and 1B (MT2). These are G-protein-coupled receptors, predominantly located in the central nervous system. MT1/MT2 agonists could be a useful treatment approach according to all three prevalent theories of the pathogenesis of depression involving either monoamines, synaptic remodeling, or immune/inflammatory events. MT1/MT2 receptors can be a potential target for novel antidepressants with impact on concentrations of neurotrophins or neurotransmitters, and reducing levels of pro-inflammatory cytokines. There is an interesting cross-talk mediated via the physical association of melatonin and serotonin receptors into functional heteromers. The antidepressive and neurogenetic effects of MT1/MT2 agonists can also be caused by the inhibition of the acid sphingomyelinase, leading to reduced ceramide, or increasing monoamine oxidase A levels in the hippocampus. Compounds targeting MT1 and MT2 receptors could have potential for new anti-depressants that may improve the quality of therapeutic interventions in treating depression and relieving symptoms. In particular, a combined effect on MT1 and/or MT2 receptors and neurotransmitter systems may be useful, since the normalization of the circadian rhythm through the melatonergic system will probably contribute to improved treatment. In this review, we discuss melatonergic receptors as a potential additional target for novel drugs for depression.
Psychoeducational training for reducing the impact of a COVID-19 pandemic on healthcare workers
(University of Nis, Faculty of Medicine, 2023) Boiko, D. I.; Mats, O. V.; Zhyvotovska, L. V.; Herasymenko, L. O.; Skrypnikov, A. M.; Бойко, Дмитро Іванович; Мац, Оксана Василівна; Животовська, Лілія Валентинівна; Герасименко, Лариса Олександрівна; Скрипніков, Андрій Миколайович
Introduction. Healthcare workers are increasingly exposed to long-term traumatic events in the context of the COVID-19 pandemic. Methods. We conducted a study that included 100 healthcare workers and 50 healthy individuals. We used the Perceived Stress Scale, Hospital Anxiety and Depression Scale, and Global Patient Impression for Improvement in the assessment of the psychological condition of respondents. To improve the psychoemotional state of health care workers, we proposed a program of psychoeducational training that was conducted at the workplace. After it, we reassessed the level of perceived stress, anxiety, and depression. Results. During the COVID-19 pandemic, in healthcare workers, the level of stress and anxiety was higher than in non-medical specialties, and the level of depression was not significantly different. The reduction of stress and anxiety was found. The subjective assessment of the improvement of the general condition indicates its positive dynamics after the psychoeducational training in both doctors and nurses. Conclusion. We showed the effectiveness of the proposed psychoeducational methodology for improving the psycho-emotional condition of healthcare workers during the COVID-19 pandemic.
Relationship between Sleep Disorders and Neuropsychiatric Symptoms in Parkinson's Disease: A Narrative Review
(2022-10) Shkodina, A. D.; Iengalychev, T. R.; Tarianyk, K. A.; Boiko, D. I.; Lytvynenko, N. V.; Skrypnikov, A. M.; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро Іванович; Литвиненко, Наталія Володимирівна; Скрипніков, Андрій Миколайович
Aim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completeness of the review, a second, more in-depth literature search was performed using the same electronic database with the search inquiries of increased specificity. Results: The information on pathophysiology, epidemiology, clinical features and risk factors was extracted and formed the basis for this review. Despite how widespread sleep disorders in Parkinson’s disease are, there is no systematic information about their association with neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment and psychosis. In this review, we described relationships between these non-motor symptoms of Parkinson’s disease, their timeline occurrence, gap in knowledge and perspectives for further research. We suppose that early treatment of sleep disorders in patients with Parkinson’s disease can reduce the incidence and extent of neuropsychiatric symptoms. Conclusion: We have demonstrated multiple, multidirectional relationships between sleep disorders and neuropsychiatric symptoms. However, some of them remain unexplored. The described knowledge can be applied to further study the possibility of influencing neuropsychiatric symptoms through the correction of sleep disorders in patients with different stages of Parkinson’s disease.
Roles of clock genes in the pathogenesis of Parkinson's disease
(Elsevier, 2022-02) Shkodina, A. D.; Tan, S. Ch.; Hasan, M. M.; Abdelgawad, Mai; Chopra, Hitesh; Bilal, Muhammad; Boiko, D. I.; Tarianyk, K. A.; Alexiou, Athanasios; Шкодіна, Анастасія Дмитрівна; Бойко, Дмитро Іванович; Таряник, Катерина Анатоліївна
Parkinson's disease (PD) is a common motor disorder that has become increasingly prevalent in the ageing population. Recent works have suggested that circadian rhythms disruption is a common event in PD patients. Clock genes regulate the circadian rhythm of biological processes in eukaryotic organisms, but their roles in PD remain unclear. Despite this, several lines of evidence point to the possibility that clock genes may have a significant impact on the development and progression of the disease. This review aims to consolidate recent understanding of the roles of clock genes in PD. We first summarized the findings of clock gene expression and epigenetic analyses in PD patients and animal models. We also discussed the potential contributory role of clock gene variants in the development of PD and/or its symptoms. We further reviewed the mechanisms by which clock genes affect mitochondrial dynamics as well as the rhythmic synthesis and secretion of endocrine hormones, the impairment of which may contribute to the development of PD. Finally, we discussed the limitations of the currently available studies, and suggested future potential studies to deepen our understanding of the roles of clock genes in PD pathogenesis.
Schizophrenia and disruption of circadian rhythms: An overview of genetic, metabolic and clinical signs
(Elsevier, 2024) Boiko, D. I.; Chopra, Hitesh; Bilal, Muhammad; Kydon, P. V.; Herasymenko, L. O.; Rud, V. O.; Bodnar, L. A.; Vasylyeva, G. Yu.; Isakov, R. I.; Zhyvotovska, L. V.; Mehta, Aashna; Skrypnikov, A. M.; Бойко, Дмитро Іванович; Кидонь, Павло Володимирович; Герасименко, Лариса Олександрівна; Рудь, Вадим Олексійович; Боднар, Леся Анатоліївна; Васильєва, Ганна Юріївна; Ісаков, Рустам Ісроїлович; Животовська, Лілія Валентинівна; Скрипніков, Андрій Миколайович
A molecular clock in the suprachiasmatic nucleus of the anterior hypothalamus, which is entrained by the dark-light cycle and controls the sleep-wake cycle, regulates circadian rhythms. The risk of developing mental disorders, such as schizophrenia, has long been linked to sleep abnormalities. Additionally, a common aspect of mental disorders is sleep disturbance, which has a direct impact on the intensity of the symptoms and the quality of life of the patient. This relationship can be explained by gene alterations such as CLOCK in schizophrenia which are also important components of the physiological circadian rhythm. The function of dopamine and adenosine in circadian rhythm should also be noted, as these hypotheses are considered to be the most popular theories explaining schizophrenia pathogenesis. Therefore, determining the presence of a causal link between the two can be key to identifying new potential targets in schizophrenia therapy, which can open new avenues for clinical research as well as psychiatric care. We review circadian disruption in schizophrenia at the genetic, metabolic, and clinical levels. We summarize data about clock and clock-controlled genes' alterations, neurotransmitter systems' impairments, and association with chronotype in schizophrenia patients. Our findings demonstrate that in schizophrenia either homeostatic or circadian processes of sleep regulation are disturbed. Also, we found an insufficient number of studies aimed at studying the relationship between known biological phenomena of circadian disorders and clinical signs of schizophrenia.
Sleep and armed conflict: future complications of war in Ukraine
(Elsevier, 2022) Shkodina, A. D.; Zhyvotovska, A. I.; Boiko, D. I.; Шкодіна, Анастасія Дмитрівна; Животовська, Анастасія Ігорівна; Бойко, Дмитро Іванович
Sleep problems in combatants with posttraumatic stress disorder and its acceptance
(Полтавський державний медичний університет, 2024) Boiko, D. I.; Бойко, Дмитро Іванович
Протягом десятиліть проблеми зі сном набувають все більшої поширеності серед військовослужбовців. Поряд з цим участь в активних бойових діях сприяє розвитку стрес-асоційованих психічних розладів, які можуть супроводжуватися порушеннями сну. Однак в медицині сну не було достеменно вивчено роль прийняття проблем зі сном. Поряд з цим на сьогодні не було вивчено рівень прийняття проблем зі сном у комбатантів, а також його відмінностей за умови наявності ПТСР. Нами проведено клінічне дослідження 45 комбатантів, яких було розподілено на 2 групи: група 1 (n=24) – комбатанти з ПТСР; група 2 (n=21) – комбатанти без ПТСР. У пацієнтів було зібрано скарги на порушення сну, проаналізовано якість сну за допомогою Пітсбургського опитувальника якості сну та визначено рівень прийняття згідно з опитувальником прийняття проблем зі сном. Встановлено переважання скарг на кошмари та труднощі із засинанням серед пацієнтів групи 1 (р<0,001 та р=0,027 відповідно). Нами встановлено, що серед учасників групи 1 погана якість сну зустрічалася статистично значуще частіше (р<0,001). Пацієнти групи 1 мали нижчий рівень залученості до активності (р=0,023) і знижений рівень прийняття проблем зі сном порівняно з групою 2 (р=0,017). Таким чином нами продемонстровано, що комбатанти мають значні проблеми зі сном та високу частоту поганої якості сну. Серед скарг на проблеми зі сном незалежно від ПТСР у комбатантів найчастіше відмічаються недостатньо відновлювальний сон та часті пробудження. При ПТСР у комбатантів спостерігається більша частота скарг на труднощі із засинанням та кошмари, а також нижчий рівень прийняття проблем зі сном, зокрема залученості до активності, що доцільно враховувати при розробці стратегії лікування та виборі психотерапевтичного підходу. For decades, sleep problems have become increasingly common among military personnel. Along with this, participation in active hostilities contributes to the development of stress-associated mental disorders, which sleep disturbances may accompany. However, sleep medicine has not thoroughly studied the role of acceptance of sleep problems. Along with this, the level of acceptance of sleep problems among combatants, as well as its differences in the presence of PTSD, has not been studied to date. We conducted a clinical study of 45 combatants, who were divided into two groups: group 1 (n=24) – combatants with PTSD; group 2 (n=21) – combatants without PTSD. Patients ‘ complaints about sleep disturbances were collected, sleep quality was analyzed using the Pittsburgh Sleep Quality Questionnaire, and acceptance level was determined according to the Sleep Problems Acceptance Questionnaire. The predominance of complaints about nightmares and difficulty falling asleep among patients of group 1 was established (p<0.001 and p=0.027, respectively). We found that among the participants of group 1, poor sleep quality occurred statistically significantly more often (p<0.001). Group 1 patients had a lower level of activity involvement (p=0.023) and a reduced level of acceptance of sleep problems compared to group 2 (p=0.017). Thus, we demonstrated that combatants have significant sleep problems and a high frequency of poor sleep quality. Among the complaints of sleep problems independent of PTSD in combatants, insufficiently restorative sleep and frequent awakenings are most often noted. With PTSD, combatants have a higher frequency of complaints of difficulty falling asleep and nightmares, as well as a lower level of acceptance of sleep problems, in particular, involvement in activities, which should be taken into account when developing a treatment strategy and choosing a psychotherapeutic approach.
Sleep quality in different motor subtypes of Parkinson's disease at the early stages
(Wiley, 2024) Shkodina, A.; Tarianyk, K.; Boiko, D. I.; Delva, M.; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро Іванович; Дельва, Михайло Юрійович
Sleep disorders in PD are represented by different diseases, but they have in common the worsening of sleep quality, which has a direct impact on the functional activity of patients. It is known that motor subtypes differ in the severity of non-motor symptoms. For example, the postural instability/gait difficulty (PIGD) subtype is predisposed to more severe sleep disturbances and fatigue. Therefore, the objective of this study was to assess the differences in sleep quality between different motor subtypes of PD.

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