Перегляд за Автор "Burmak, Y. H."

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  • Ескіз недоступний
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    Changes in the indicators of stiffness and remodeling of magistral arteries in young patients at the early stage of essential hypertension under conditions of syntropy with obesity
    (Aluna Publishing, 2024) Ivanytska, T. A.; Kazakov, Y. M.; Petrov, Y. Y.; Burmak, Y. H.; Ivanytskyi, I. V.; Chekalina, N. I.; Shut, S. V.; Іваницька, Тетяна Анатоліївна; Казаков, Юрій Михайлович; Петров, Євген Євгенович; Бурмак, Юрій Григорович; Іваницький, Ігор Валерійович; Чекаліна, Наталія Ігорівна; Шуть, Світлана Володимирівна
    The study and analysis of indicators of remodeling and rigidity of magistral vessels in young essential hypertension patients with abdominal obesity and determination of the detected changes as a possible criterion for their remodeling.
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    Changes of endothelial function indices and pro-inflammatory cytokines level in comorbid course of essential hypertension
    (NGO European Scientific Platform, 2022-08-05) Burmak, Y. H.; Petrov, Ye. Ye.; Ivanytska, T. A.; Іvanytskyi, І. V.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Іваницька, Тетяна Анатоліївна; Іваницький, Ігор Валерійович
    It should be noted that the peculiarity of internal pathology at present time is its comorbidity, besides essential hypertension (EH) sintropy worsens disease on the whole. Combination of EH with duodenal peptic ulcer (DPU) is frequent. It can complicate diagnostics, modify clinical symptoms and worsen treatment quality. The study aimed to identify the features of the changes of endothelial function parameters and pro-inflummatory cytokines level in patients with EH and comorbid DPU.
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    The effectiveness of the influence of a bioflavonoid and enterosorbent combination on changes in the content of leukotrienes and oxidative stress products in the early terms of treatment of comorbid peptic ulcer in patients with essential hypertension
    (Singapore, Republic of Singapore, 2023) Burmak, Y. H.; Petrov, Ye. Ye.; Ivanytska, T. A.; Іvanytskyi, І. V.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Іваницька, Тетяна Анатоліївна; Іваницький, Ігор Валерійович
    The presence of local and systemic modulating effects in leukotrienes (Ltt), their influence on the initiation of the production of platelet activating factors and neutrophil binding, the release of lysosomal enzymes, the formation of superoxide anions, as well as their direct participation during inflammation suggest that the dynamics of changes in the content of Ltt and lipid peroxidation products are one of the possible indicators of the effectiveness of the treatment of the disease. Taking into account the possibility of qualitative and quantitative changes in the content of biologically active substances and changes in metabolic parameters in patients under conditions of syntropy, we undertook the present study, the purpose of which was to study and analyze the dynamics of changes in the content of lipoxygenase metabolites of arachidonic acid and products (intermediate and final) of lipid peroxidation in early terms of treatment of peptic ulcer of the duodenum (DPU) and in patients with essential hypertension (EH). In the treatment of comorbid pathology, our attention was drawn to two drugs: the enterosorbent silicon dioxide (atoxyl), which effectively adsorbs products of incomplete metabolism from the intestine and blood, and the representative of bioflavonoids, the antioxidant and antihypoxant quercetin.
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    The expression of metabolic changes and factors of non-specific resistance in patients with chronic bronchitis and comorbid peptic ulcer at different termsof treatment and outpatient observation
    (Кембридж, Великобританія, 2023-08-18) Burmak, Y. H.; Petrov, Ye. Ye.; Ivanytska, T. A.; Іvanytskyi, І. V.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Іваницька, Тетяна Анатоліївна; Іваницький, Ігор Валерійович
    The process of recovery after treatment of an exacerbation of chronic bronchitis (ChB) with conventional pathogenetic therapy most often proceeds for several weeks, while various residual effects in the form of post-infectious asthenia can be observed, and the presence of comorbidity can negatively affect the course of the disease and contribute to its progression. During the progression of respiratory diseases, there is a violation of phagocytosis with an increase in the activity of pro-inflammatory cytokines, the intensity of lipid peroxidation, with a decrease on the activity of the antioxidant system, and a significant role is played by a violation of the function of the endothelium.The above actively affects the remodeling of the bronchial tract and the development of bronchial obstruction, damage to vessels of various calibers and changes in systemic and microhemodynamics, and in conditions of comorbidity, long-term maintenance of a local inflammatory process which implies the search for ways to correct these changes. We did not exclude the possibility of changes of non-specific immune resistance, the intensity of lipid peroxidation and changes in nitric oxide metabolism in patients with ChB and comorbid peptic ulcers of the duodenum (PDU), the presence of which required timely correction. The aim of the study was to investigate the effect of combination of sodium desoxyribonucleate and vitamin-antioxidant complex with selenium on the phagocytic activity of monocytes (PhAM), the intensity of lipid peroxidation (LPO) and the metabolism of nitroxide (NO) in patients with ChB (before/after exacerbation) and comorbid PDU at different terms of treatment and outpatient observation.