Перегляд за Автор "DuBuske, L. M."
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Документ Comparison of the Prevalence of Polymorphisms of TLR4 Asp299Gly in Patients with Bacterial Sexually Transmitted Diseases Versus the General Population in Ukraine(2010) Kaidashev, I. P.; Izmaylova, O. V.; Shlykova, O. A.; DuBuske, L. M.; Кайдашев, Ігор Петрович; Ізмайлова, Ольга Віталіївна; Шликова, Оксана АнатоліївнаBackground: Mutations in genes that encode Toll Like Receptors (TLRs) have been associated with increased or decreased susceptibility to various infectious diseases. ’ This study assesses the prevalence of TLR4 Asp299Gly polymorphism in the Poltava, i I Ukraine general population and in patients with common urogenital infections. Methods: T1_R4 Asp299Gly gene polymorphisms were determined by polymerase chain reaction (PCR) using specific primers followed by oligonucleotide restriction i analysis. 299 healthy inhabitants of Poltava region of Ukraine and 156 patients with urogenital infections including Chlamydiosis (n=16). Ureaplasmosis (n=102). Mycoplasmosis (n=4). Gardnerellosis (n=9). Trichomoniasis (n=2). and having multiple urogenital infections (n^23) all diagnosed by PCR. were assessed for TLR4 gene polymorphisms.Документ The Influence of Pioglitazone on NFkB Expression in CD40+ OrO Lymphocytes is Polymorphism-Dependent(Washington, 2009) Kaidashev, I. P.; Kutzenko, N.; Shlykova, O.; DuBuske, L. M.; Кайдашев, Ігор Петрович; Куценко, Н.; Шликова, Оксана АнатоліївнаExpression of CD40 cells was unchanged in control or P cul tures. Expression of NFkB in CD40-positive cells significantly increased in all control cultures after 24 hours incubation. Addition of P to MNC in duced from 5 to 25% dose-dependent decrease in NFkB expression. The impact of P on CD40+ cells with the Prol2Ala polymorphism of PPAR- 7 was greatest on MNC from patients bearing the Alal2 allele.