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Документ Adaptive responses of cardiovascular system and non-specific resistance of the body in cases of mandibular fracture(Українська медична стоматологічна академія, 2019) Nahirniy, Ya. P.; Fesyk, V. L.; Avetikov, D. S.; Lokes, E. P.; Нагірний, Ярослав Петрович; Фесик, Віталій Любомирович; Аветіков, Давид Соломонович; Локес, Катерина Петрівна; Нагирный, Ярослав Петрович; Фесик, Виталий Любомирович; Аветиков, Давид Соломонович; Локес, Екатерина ПетровнаThe purpose of the research was to study the peculiar features of the autonomic nervous system response to the injury by the parameters of cardiovascular system and changes in non-specific resistance of the body in cases of open traumatic mandibular fracture in patients of different psychosomatic personality types. Sixty males diagnosed with traumatic open unilateral mandibular angle fracture, as well as 36 extraverts and 24 introverts, were examined. The study of vegetative tonus has proved that among the extraverts in 44.4% of cases, the autonomic nervous system is in a state of functional balance, whereas in the introverts it only occurs in 25% of cases. It has been established that extraverts in the early post-traumatic period have better adaptabilities of the non-specific resistance system; Метою дослідження було вивчення особливостей реакції вегетативної нервової системи на травму за показниками серцево-судинної системи і змінами неспецифічної резистентності організму у постраждалих з травматичними відкритими переломами нижньої щелепи різного психосоматичного типу особистості. Обстежено 60 осіб чоловічої статі, у яких діагностовано травматичні односторонні відкриті переломи нижньої щелепи в області кута, з них 36 екстраверта і 24 інтроверта. Дослідження вегетативного тонусу показало, що серед осіб-екстравертів в 44,4% випадків вегетативна нервова система перебуває в стані функціонального рівноваги, тоді як у інтровертів – лише в 25% випадків. Встановлено, що екстраверти в ранній період після травми мають більші адаптаційні можливості системи неспецифічної резистентності; Целью исследования было изучение особенностей реакции вегетативной нервной системы на травму по показателям сердечно-сосудистой системы и изменениям неспецифической резистентности организма у пострадавших с травматическими открытыми переломами нижней челюсти разного психосоматического типа личности. Обследовано 60 человек мужского пола, у которых диагностированы травматические односторонние открытые переломы нижней челюсти в области угла, из них 36 экстраверта и 24 интроверта. Исследование вегетативного тонуса показало, что среди лиц-экстравертов в 44,4% случаев вегетативная нервная система находится в состоянии функционального равновесия, тогда как у интровертов только в 25% случаев. Установлено, что экстраверты в ранний период после травмы имеют большие адаптационные возможности системы неспецифической резистентности.Документ Дослідження клітинної ланки імунітету при травматичних переломах нижньої щелепи в постраждалих різного психосоматичного типу особистості(Українська медична стоматологічна академія, 2017) Нагірний, Я. П.; Фесик, В. Л.; Nahirniy, Ya. P.; Fesyk, V. L.Вивчено особливості реакції клітинної ланки імунітету на травму в 60 постраждалих із травматичними переломами нижньої щелепи різного психосоматичного типу особистості, серед яких було 36 екстравертів і 24 інтроверти. Отримані результати свідчать про тотальну депресію в них клітинної ланки імунітету в 1-й день після травми. Стабілізація порушених ланок відбувалася по-різному. У осіб-екстравертів на 7-й день після травми відбувалася стабілізація тільки субпопуляцій СD3+-, СD8+-, СD16+-лімфоцитів, а в осіб - інтровертів – СD4+- і СD16+-лімфоцитів; Изучены особенности реакции клеточного звена иммунитета на травму в 60 пострадавших с травматическими переломами нижней челюсти разного психосоматического типа личности, среди которых было 36 экстравертов и 24 интроверта. Полученные результаты свидетельствуют о тотальной депрессии у них клеточного звена иммунитета в 1-й день после травмы. Стабилизация нарушенных звеньев происходила по-разному. У лиц-экстравертов на 7-й день после травмы происходила стабилизация только субпопуляций СD3+ -, СD8+ -, СD16+ лимфоцитов, а у лиц - интровертов - СD4 + - и СD16 + лимфоцитов; The high risk of purulent complications in treatment of traumatic open mandibular fractures, which frequency is 35-41,0%, is caused by the presence of a significant amount of microflora in an oral cavity, mucous membrane ruptures in the area of fracture and also significantly by body defences state. According to the recent literature, it is established that during treatment of patients with traumatic mandibular fractures their psychosomatic state influences on the development of purulent complications. This influence occurs due to different degree of the effect of psyche on immune system that is crucial in purulent complications development. However, there are no researches in immune perturbations depending on psychosomatic type of personality of patients with mandibular fractures. The aim of the research was to study functional disorders of immune system cellular component in patients with traumatic mandibular fractures depending on psychosomatic type of personality. Material and Methods The dynamics of immune status rate was studied in 60 male patients diagnosed with traumatic unilateral open mandibular fractures in the area of a corner, average age was 25.2±5.0 years old. The patients were divided into two groups: extraverts (the 1st group, 36 individuals), introverts (the 2nd group, 24 individuals) according to the Eysenck’s classification. The researches were conducted on the 1st, 3rd, 7th day after a trauma. Identification of T- and B-lymphocytes was performed by means of Status monoclonal antibodies. The quantity of subpopulations CD3+-, CD4+-, CD8+-, CD16+- lymphocytes was evaluated in percent. Results and Discussion The results of the research of a cellular component of immunity proved the decrease in relative quantity of the general pool of T-lymphocytes (CD3+) in both studied groups. The tendencies of their quantitative changes were similar. However, in the patients of the 1st group (the extraverts) on the 7th day of the research, a complete restitution of the quantity of T-lymphocytes (CD3+) was evinced. This rate even exceeded the level of the control group by 5.1%, whereas in the patients of the 2nd group (the introverts) a complete restitution of the quantity of CD3+- lymphocytes was not evidenced, the quantity was lower by 1.9% in comparison with the control. The decrease of total T- lymphocytes took place due to the decrease in subpopulations of T-helpers (CD4+) and T-suppressors (CD8+). The tendencies of quantitative changes of CD4+- lymphocytes in the compared groups differed in the rate of complete restitution of the quantity to the level of the control group on the 7th day of the research that was evidenced only in the patients of the 2nd group (the introverts) and the rate of the 1st group of patients (extraverts) did not reach the level of the control group. The level of Tsuppressors (CD8+) significantly decreased in both compared groups on the 1st day after trauma, and on the 7th day of the monitoring the rate of the extravert group exceeded the level of the control group, and the introvert group did not reach the control rate. The dynamics of the changes of killer lymphocytes rate proved their higher functional activity in the extraverts. Conclusions The results of the research have proved complete depression of T-cellular component of immunity in both studied groups on the 1st day after trauma. Stabilization of the damaged components of immune system in the compared groups was different. On the 7th day after trauma, the stabilization of CD3+-, CD8+-, CD16+- lymphocytes subpopulations was evidenced in the extraverts, and CD4+- and CD16+-lymphocytes subpopulations reached the norm in the introverts.Документ Особливості гемограми й імунного статусу постраждалих із травматичними переломами нижньої щелепи залежно від типу особистості(Українська медична стоматологічна академія, 2017) Нагірний, Я. П.; Фесик, В. Л.; Nahirnyi, Ya. P.; Fesyk, V. L.У 32 постраждалих із травматичними відкритими односторонніми переломами нижньої щелепи в ділянці кута з різним психосоматичним типом, визначеним за методикою Айзенка, вивчено особливості змін гемограми й імунного статусу в ранній період після травми. Установлено, що кількісні показники гемограми й імунного статусу корелюють із психосоматичним типом особистості; У 32 пострадавших с травматическими открытыми односторонними переломами нижней челюсти в области угла с различным психосоматическим типом, определенном по методике Айзенка, изучены особенности изменений гемограммы и иммунного статуса в ранний период после травмы. Установлено, что количественные показатели гемограммы и иммунного статуса коррелируют с психосоматическим типом личности; Violation of the immune status of patients with traumatic lower jaw bone fractures has been found in recent years researches. It is known, that the stress that accompanies an injury, significantly affects the reactivity, and severity of reactions depends on its individual characteristics. According to the analysis of the available literature the first publications concerning the importance of patient psychical status in the occurrence and course of dental diseases are dated by 1988 and the issue still remains actual [7]. The emotional state of patients with traumatic fractures of the lower jaw bone became a subject of investigation more than a decade ago. However, there were not found any reports on the features of their immune system response depending on their emotional state. The aim of our investigation was to identify the characteristics of quantitative changes in hemogram and immune system of patients with traumatic fractures of the lower jaw bone depending on the type of person in order to improve their treatment and rehabilitation. Material and methods. Conduction of a psychological testing and clinical examination of 32 injured males with traumatic unilateral opening fractures of the lower jaw bone in the angle area was detected. Type of the injured individual was determined by the Eysenck test. According to the test results they were divided into two groups: extroverts and introverts. We investigated the indicators of the expanded blood analysis with leukocyte formula in terms of SI. These indicators were compared with the indicators of reference base. The level of the immune system indicators of all injured was followed up (in the 1st and 3rd day after injury). The identification of T- and B-lymphocytes was carried out using monoclonal antibodies. The number of CD3+, CD4+,CD8+, SD72+-lymphocytes subpopulations was determined in percentage. The A, M, G immunoglobulin concentration was determined by G. Mancini et al. The indicators were compared to the ones of the control group consisting of 18 males without comorbidity. Results and discussion. In the course of analysing the indicators of red blood of most patients were found to be within normal limits. Some injured had different indicators. Thus, among introverts there were about 2 times more victims who had hemoglobin content and color index, which were lower compared to those of the reference base. Erythrocyte sedimentation rate of 56% of injured of both groups increased. Leucogram analysis revealed the following features there were more patients found with lymphocytosis among extroverts: 36.8% of patients had lymphopenia, whereas extroverts did not. Changes of in segmented lymphocytes quantity of studied groups were opposing: in the, their number in the extroverts organism decreased, while in introverts one it increased. The changes of immunity indicators were of the same type in both comparable groups, but their severity was different. Reducing of CD3+, CD4+-lymphocytes level was more significant in an introvert’s organism, while the number SD72+-lymphocytes was bigger in the and extrovert’s noe. Increasing the level of IgA and IgM was more expressed in extroverts. The dynamics of changes in IgG didn’t differ in the two groups and was characterized by slight increase in its content and stabilization of the 3-day studying. The results show that changes of hemogram and immune status of patients with traumatic fractures of the lower jaw bone with a different psychosomatic type are unidirectional, but the severity of the deviations is different. In introverts the anemic syndrome is more pronounced, their cellular immunity is characterized by stronger suppression, leukocytosis is more pronounced, while the number of lymphocytes and eosinophils was higher in extroverts. The features of changes in hemogram and immune status in the early period after injury of 32 patients with various psychosomatic types defined by the Eysenck method with unilateral traumatic open fractures of the lower jaw bone in the angle area were studied. The quantitative parameters of hemogram and of immune status correlate with psychosomatic type of personality was established.