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Документ Predictors of myocardial ischemia and central hemodynamic disorders in patients with coronary heart disease(2018) Kazakov, Yu.; Gorach, N.; Vakulenko, K.; Shlykova, O.; Izmaylova, O.; Казаков, Юрій Михайлович; Горач, Н.; Вакуленко, Костянтин Євгенійович; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга ВіталіївнаCoronary heart disease (CHD) ranks first among mortality causes in the world over the years Present scientific studies prove the leading role of chronic systemic inflammation (CSI) in the onset and progression of atherosclerosis (ASVD), which has been the morphological basis of CHD . Taking into account the above-mentioned, it is relevant to study the interaction of components of the pathogenetic process in the ASVD and CHD, the factors of formation and progression of the specified pathology in order to determine the diagnostic markers for the development and destabilization of these diseases and developing rational therapeutic approaches. The purpose of our research was to study the relationship between the indicators of systemic inflammation, the lipid spectrum of blood and the structural and functional condition of the heart in patients with stable CHD, and the search for predictors of its progressionДокумент Predictors of myocardial ischemia and central hemodynamic disorders in patients with coronary heart disease(2018) Kazakov, Yu.; Gorach, N.; Vakulenko, K.; Shlykova, O.; Izmaylova, O.; Казаков, Юрій Михайлович; Вакуленко, Костянтин Євгенійович; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга ВіталіївнаMaterials and methods. One-time, open-label, single group clinical trial involved 115 patients with CHD: stable angina pectoris, FC II, НF 0-І (62 men and 53 women aged 54±6.2). Patients were given laboratory and instrumental studies. The levels of total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), triglycerides (TG) by sedimentation, fibrinogen (Fg) concentration in blood by gravimetric analysis, the level of cytokines (CK) in the blood (interleukin 1β (IL-1β), tumor necrosis factor (TNFα), interleukin 10 (IL-10)) by the immune enzyme method, the content of circulating endothelial microparticles (EMP) of CD32+CD40+ in blood by cytofluorometry, mRNA gene expression of kappa B-alpha inhibitor (IkBα) of the nuclear kappa B transcription factor (NF-kB) in mononuclear cells of the peripheral blood by real-time polymerase chain reaction (Real-time PCR) were being determined [4, 5, 6]. Echocardiography and the 24 hour Holter ECG monitoring were performed by the standard method. A correlation and regression analysis was conducted.