Перегляд за Автор "Hryn, V. G."
Зараз показуємо 1 - 2 з 2
Результатів на сторінці
Налаштування сортування
Документ Progress and problems of vaccination against coronavirus infection Covid-19(Полтавський державний медичний університет, 2022-09-16) Karatash, A. V.; Bilanova, L. P.; Bilash, S. M.; Pronina, O. M.; Bilash, V. P.; Hryn, K. V.; Hryn, V. G.; Oliinichenko, Ya. O.; Караташ, Андрій Вячеславович; Біланова, Лариса Павлівна; Білаш, Сергій Михайлович; Проніна, Олена Миколаївна; Білаш, Валентина Павлівна; Гринь, Катерина Вікторівна; Гринь, Володимир Григорович; Олійніченко, Ярина ОлександрівнаThis article is devoted to the main achievements and problems associated with vaccination against the COVID-19 coronavirus infection. This problem remains relevant as the coronavirus infection is a highly contagious disease that spreads widely worldwide. Vaccination is currently the most effective way to prevent the occurrence of a coronavirus infection or its severe consequences. The difficulty is that vaccination against COVID-19 is effective only when the antigenic structure of the circulating virus matches the antigens contained in the vaccine (or, in the case of RNA and DNA vaccines, the viral antigens programmed into the genetic code). However, the coronavirus is constantly changing its genetic structure, resulting in new strains that differ from circulating variants and have pandemic potential, against which existing vaccines may be ineffective. This study aimed to determine the main approaches to creating a vaccine's advantages and disadvantages of vaccination through bibliographic analysis. A literature search was conducted among published peer-reviewed articles, books, textbooks, and monographs. The obtained data were systematized and processed. Attention was paid to the main approaches to creating vaccines against COVID-19; the problems of immunological imprinting and antibody-dependent enhancement of infection were assessed. It was established that strategies based on the use of DNA and RNA vaccines to solve the problem of their low immunogenicity in humans are a real alternative for the future development of medicine in the prevention of infectious diseases.Документ The sructure of the harderian, extraorbital and infraorbital lacrimal glands ducts of the laboratory rats(Полтавський національний педагогічний університет імені В. Г. Короленка, 2022) Katsenko, A. L.; Sherstyuk, O. O.; Svintsytska, N. L.; Ustenko, R. L.; Hryn, V. G.; Lytovka, V. V.; Korchan, N. O.; Каценко, Андрій Любославович; Шерстюк, Олег Олексійович; Свінцицька, Наталія Леонідівна; Устенко, Роман Леонідович; Гринь, Володимир Григорович; Литовка, Володимир Вікторович; Корчан, Наталія ОлександрівнаThe aim of the study was to determine and compare the structure of the excretory ducts of the Harderian gland, extraorbital and infraorbital lacrimal glands of laboratory rats. Object and methods. Five male laboratory rats were examined by dissecting the lacrimal glands, from which series of thin paraffin sections were obtained for histological examination. Micropreparations were stained with hematoxylin and eosin and examined under a light microscope. Results. It was found that the tubuloalveolar epithelial components of the extraorbital gland of rats in the middle of the lobe are even denser than in the infraorbital gland, as evidenced by very narrow interstitial fissures. The lacrimal glands of laboratory rats have an individual well-defined connective tissue capsule. Inside the capsule and between the lobes there are slitlike interepithelial interstitial spaces, in which we don`t detect clusters of lipocytes, as occurs in the lacrimal glands of human. In the volume of lobes, both extraorbital and infraorbital glands, the interepithelial interstitial spaces contain vessels of the hemomicrocirculatory tract, mainly capillaries, precapillary arterioles and postcapillary venules. Arterioles and venules are usually visualized outside the lobes in more pronounced interstitial spaces.