Перегляд за Автор "Ishcheikin, K. E."

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    Pharmacoeconomic approaches for pharmacotherapy of rheumatoid arthritis
    (Національна медична академія післядипломної освіти імені Шупика, Інформаційно-науковий центр "Лікарська справа", 2021) Hayduchok, I. G.; Shapovalova, V. O.; Ishcheikin, K. E.; Chopyak, V. V.; Shapovalov, V. V.; Shapovalov, V. V.; Гайдучок, І. Г.; Шаповалова, В. О.; Іщейкін, Костянтин Євгенович; Чопяк, В. В.; Шаповалов, В. В. (мол.); Шаповалов, В. В.
    With the spread of the coronavirus pandemic, the role of pharmacotherapy of rheumatoid arthritis (RA) among patients with dual health disorders and in patients with systemic diseases is growing. This article is devoted to pharmacoeconomic for the pharmacotherapy of RA based on ABC/VEN analysis. Materials and methods. International and national medical and technological documents on standardization of medical care of RA, as well as scientific sources were used for regulatory, documentary and pharmacoeconomic analysis. ABC analysis was performed as a tool to study the cost of purchasing drugs. VEN analysis was performed to classify drugs into categories V, E and N on the principles of evidence-based medicine, forensic pharmacy, evidence-based pharmacy. Results. On thefirst stage of the research was conducted clinical and pharmacological analysis, the next stages – marketing and pharmacoeconomic analysis. Based on the ABC/VEN analysis, a matrix of the consolidated ABC/VEN analysis was developed. Discussion. The largest share (66.7 %) falls on the ATC classification code L “Antineoplastic and immunomodulatory agents”. According to the results of marketing analysis tablets occupy 50 % of doctors’ appointments; 75 % of the studied drugs have an unlimited validity of registration certificates. Ranking of country of origin of manufacturers of studied drugs: Germany – 37.6 %. Category A included five drugs’ INN (Mycophenolic acid, Azathioprine, Cyclophosphamide, Methotrexate, Ciclosporine), the cost of one dose is 5241.1 UAH, which is 78.12 % of the total cost of treatment for a patient with RA. It was found that six drugs INN (Methotrexate, Sulfasalazine, Hydroxychloroquine, Azathioprine, Ciclosporine, Cyclophosphamide) belong to category V (Vital). Conclusion. The introduction of information about pharmacoeconomic for pharmacotherapy of RA in the activities of health care institutions will ensure proper organization of the order of drug circulation at the stages of prescribing, prescribing, storage, accounting, quality control, transportation, release, destruction, licensing in accordance with current medical and pharmaceutical legislation.
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    Документ
    Subcutaneous adipose tissue in female patients with iron deficiency anemia and obese women does not differ in the expression of ikbα
    (Полтавський державний медичний університет, 2018) Nedoborenko, V. M.; Shlykova, O. A. ; Izmailova, O. V.; Ishcheikin, K. E.; Kaidashev, I. P.; Недоборенко, Вадим Михайлович; Шликова, Оксана Анатоліївна; Ізмайлова, Ольга Віталіївна; Іщейкін, Костянтин Євгенович; Кайдашев, Ігор Петрович
    Prerequisites and objective: Abdominal obesity is a common metabolic disease characterized by excessive accumulation of white adipose tissue, with excessive production of inflammatory mediators that activate transcriptional nuclear factors, in particular the nuclear factor kB. Hepcidin is the main hormone in the systemic regulation of iron. Its expression in- creases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. Therefore, the aim of the research was to determine the level of expression of ІКβα in subcutaneous adipose tissue in iron deficiency anemia concurrent with obesity. Meth- ods: The study included 40 female women. Hemogram parameters, parameters of iron metabolism (serum iron, ferritin, hepcidin, total iron binding ability of serum, saturation of transferrin by iron) in serum and level of expression of the IkBα gene in subcutaneous adipose tissue were evaluated. Research results. The examined women had an average age of 40.3 ± 7.59 years. In the distribution of patients due to the cause and degree of severity of IDA, there was no reliable difference between the groups. The control group consisted of 10 obese women without IDA. Expression of IkBα by sub- cutaneous adipose tissue in female patients with IDA with and without obesity compared with the control group did not display a significant difference between the groups (p <0.05). In the course of correlation analysis, the expression of IkBα by subcutaneous adipose tissue to BMI, iron and hemogram rates did not have a correlated significance. Conclu- sion. Subcutaneous adipose tissue in women with iron deficiency anemia with and without obesity compared with obese women has no difference in expression of IkBα.