Перегляд за Автор "Kadamov, Y."
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Документ Activation of antioxidant defenses in whole saliva by psychosocial stress Is more manifested in young women than in young men(PLoS ONE, 2014-12) Tsuber, V.; Kadamov, Y.; Tarasenko, L.; Цубер, Вікторія Юріївна; Тарасенко, Лідія МусіївнаPsychosocial stress has been long known to have deleterious effects on health. Nevertheless, an exposure to moderate stressors enhances resilience and promotes health benefits. Male and female organisms differ in many aspects of health and disease. The aim of this study was to investigate antioxidant activity and oxidative damage in saliva in a psychosocial stress paradigm in men and women. Here, we show that an acute stressor of moderate strength augments antioxidant activity and decreases oxidative damage in whole saliva of young people. An examination stress caused a significant increase of catalase activity, accompanied by a decrease of levels of oxidized proteins. Levels of thiobarbituric acid-reacting substances did not increase at stress, indicating that lipid peroxidation was not activated. The stress-induced alterations were more manifested in young women compared to young men. Thus, antioxidant protective mechanisms are more activated by a moderate stressor in young women than in young men.Документ Mutations in cancer cause gain of cysteine, histidine and tryptophan at the expense of a net loss of arginine on the proteome level(MDPI, 2017-07-03) Tsuber, V.; Kadamov, Y.; Brautigam, L.; Warpman-Berglund, U.; Helleday, T.; Цубер, Вікторія ЮріївнаAccumulation of somatic mutations is critical for the transition of a normal cell to become cancerous. Mutations cause amino acid substitutions that change properties of proteins. However, it has not been studied to what extent the composition and accordingly chemical properties of the cell proteome is altered as a result of the increased mutation load in cancer. Here, we analyzed data on amino acid substitutions caused by mutations in about 2000 protein coding genes from the Cancer Cell Line Encyclopedia that contains information on nucleotide and amino acid alterations in 782 cancer cell lines, and validated the analysis with information on amino acid substitutions for the same set of proteins in COSMIC (v78) in circa 18000 tumor samples. We found that nonsynonymous single nucleotide substitutions in the analyzed proteome subset ultimately result in a net gain of cysteine, histidine and tryptophan at the expense of a net loss of arginine. The extraordinary loss of arginine may be attributed to some extent to composition of its codons as well as to importance of arginine in functioning of prominent tumor suppressor proteins like p53.