Перегляд за Автор "Kolesnichenko, M. O."

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    Changes in the biochemical indicators of mandibula bone tissue after removal of molars and augmentation of the alveolar process
    (Полтавський державний медичний університет, 2023) Kolesnichenko, M. O.; Savchenko, D. V.; Savchenko, V. V.; Ivanyuk, O. S.; Zhivotovskyi, I. V.; Lokes, K. P.; Колесніченко, М. О.; Савченко, Д. В.; Савченко, В. В.; Іванюк, О. С.; Животовський, Ігор Володимирович; Локес, Катерина Петрівна
    Dental rehabilitation of patients with secondary adentia is a common problem in modern medicine. Atrophy of the alveolar process after tooth extraction can be a contraindication for the placement of dental implants or worsen the aesthetic result of the placed implant or reconstructive prosthetics. The study aimed to investigate the changes in the biochemical parameters of the connective tissue after removing the mandibular molars using classical and author's methods. The study involved patients who had mandibular molars removed according to the classic method (control group – 25 people), additionally underwent alveolar augmentation with "Cerabone" granules (1 group – 25 people) and the use of "Cerabone" granules in combination with a keratoxenoimplant (2nd group – 25 people). The following biochemical indicators of non-collagenous proteins were investigated: hexuronic acids, chondroitin sulfates, N-acetylneuraminic acid, and non-protein-bound fucose in mandibular bone tissue. At the time of the surgical stage of dental implantation in patients of the first group, a decrease in the content of hexuronic acids was established by 5.4% compared to the first day of the study, for the second - by 3.7%, for the control group - by 11.9%. A decrease in the content of chondroitin sulfates by 8.7%, 13.4% and 15.4% was noted for the first, second and control groups. The level of fucose not bound to proteins significantly increased by 5.1% in the control group. A probable decrease in the content of N-acetylneuramine was noted in all three groups relative to the first observation period by 8.6%, 3.5% and 19.6%, respectively. The content of hexuronic acids and N-acetylneuraminic acid underwent the most significant changes. Using "Cerabone" granules both as a monodrug and combined with a keratoxenoimplant for augmentation of the alveolar process bone defect contributed to a less pronounced decrease in the level of proteoglycans and glycoproteins compared to the control.
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    Документ
    Dynamics of changes in biochemical markers of blood serum after removal of mandibular molars and augmentation of the alveolar process
    (Полтавський державний медичний університет, 2023) Kolesnichenko, M. O.; Savchenko, D. V.; Savchenko, V. V.; Ivaniuk, O. S.; Zhyvotovskyi, I. V.; Yacenko, P. I.; Lokes, K. P.; Колесніченко, М. О.; Савченко, Д. В.; Савченко, В. В.; Іванюк, О. С.; Животовський, Ігор Володимирович; Яценко, Павло Ігорович; Локес, Катерина Петрівна
    The article describes the dynamics of connective tissue markers in blood serum (glycoproteins and chondroitin sulfates) under the conditions of mandibular molars extraction and augmentation of the alveolar process. According to the obtained data, it was established that the operation of tooth extraction and augmentation of the bone defect of the alveolar process of mandible caused more significant changes in the content of blood serum glycoproteins than chondroitin sulfates. The minimal changes in the studied parameters were observed in the second experimental group (when augmentation of the bone defect of the mandibular alveolar process with bone substitute of animal origin granules in combination with keratoxenoimplantant was performed after the molar extraction), the most significant changes were noted in the control group, in which no augmentation of the alveolar process was performed at all.