Перегляд за Автор "Kozlenko, T. V."
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Документ Changes of some immune and metabolic indices as burdening criterion of chronic systemic inflamation in the presence of the essential hypertension comorbidity(2017) Burmak, Yu. G.; Kazakov, Yu. M.; Treumova, S. I.; Shilkina, L. N.; Petrov, Ye. Ye.; Kozlenko, T. V.; Бурмак, Юрій Григорович; Казаков, Юрій Михайлович; Треумова, Світлана Іванівна; Шилкіна, Людмила Миколаївна; Петров, Євген Євгенович; Козленко, Тетяна ВікторівнаThe article highlights the cytokine profile features, severity of oxidative stress, changes of endothelium functions in patients with isolated course of essential hypertension and its combination with duodenal peptic ulcer. It describes evaluation of chronic systemic inflammation data: the level of serum cytokines (tumor necrosis factor -α, interleukins -1β, -6, -10), content of intermediate and end products of lipid peroxidation in blood (conjugated dienes, malondialdehyde), activity of antioxidant defense enzymes (superoxide dismutase, catalase), change of endothelium function (level of stable metabolites of nitrogen oxide in blood serum and severity of ristomycin-induced platelet aggregation). It was discovered that in the presence of tendency to increasing of interleukin-10 (р>0,05) , content of tumor necrosis factor -α, interleukins -1β and -6 in patients under condition of comorbidity significantly exceeded the reference data (р<0,001) and the data of patients with isolated course of essential hypertension. Thus was predetermined significant increase of ratio of pro-inflammatory cytokines to interleukin-10 that emphasized the presence of the highest pro-inflammatory activity of blood in patients with comorbid pathology. Later on in patients with comorbid pathology were identified the most significant manifestations of oxidative stress that was reflected in the highest level of conjugated dienes and malondialdehyde (р<0,001). It also turned out that the process of lipid peroxidation was proceeding under the condition of superoxide dismutase and catalase activity deficit that caused the greatest decrease of integrated indscator of the antioxidant capacity of the blood (р<0,001). It was discovered the negative relationship between high pro-inflammatory activity and low antioxidant ability of blood, reflecting the commonality of immune and metabolic processes in the mechanisms of the comorbid pathology development. This was also confirmed by the presence of inverse relationship between low total content of stable metabolites of nitrogen oxide in blood, as a reflection of the severity of endothelium dysfunction, and high pro-inflammatory blood activity (р<0,01) that also had a direct relationship with high ristomycin-induced platelet aggregation (р<0,01), as a high thrombogenic risk indicator in this category of persons. Therefore, identifying the relationship between indicators of chronic systemic inflammation in patients with essential hypertension in combination with duodenal peptic ulcer should be considered as a manifestation of a single mechanism of comorbid pathology formation, and most of their severity - as a burdening criterion of essential hypertension comorbidity.Документ The peculiarities of the changes of some cardiohemodynamic and microcirculatory indices in conditions of the comorbid course of essential hypertension(The New Armenian medical Journal., 2020) Burmak, Yu. G.; Petrov, Ye. Ye.; Kazakov, Yu. M.; Chekalina, N. I.; Treumova, S. I.; Tribrat, T. A.; Ivanitskaya, T. A.; Kozlenko, T. V.; Бурмак, Юрій Григорович; Петров, Євген Євгенович; Казаков, Юрій Михайлович; Чекаліна, Наталія Ігорівна; Треумова, Світлана Іванівна; Трибрат, Тетяна Анатоліївна; Іваницька, Тетяна Анатоліївна; Козленко, Тетяна ВікторівнаThe peculiarities of cardiohemodynamics, microcirculation, and microvasculature are presented in the article; their correlation with significance of the oxidative stress, the level of antioxidative blood potential and endothelial function in the isolated course of essential hypertension and in conditions of its comorbidity with duodenal peptic ulcer was carried out. The structural-functional indices and parameters of cardiohemodynamics, indices of microcirculation and microvasculature, the content of the intermediate and the final products of lipid peroxidation in the blood, activity of enzymes of the antioxidant protection system and indices of endothelial function were estimated. It was established that the presence of the remodeling left ventricle (a significant increase of the left heart chambers, symmetrical myocardial hypertrophy) with the unchanged contractile function, and maximal intensity of both resistivity of the peripheral vascular system (р <0.001), and disorders of microcirculation and microvasculature on the perivascular, vascular, and intravascular levels (р <0.001) is typical of the patients with the comorbid course of essential hypertension. The next results showed that manifestations of oxidative stress were the most significant (the increase of diene conjugates and malondialdehyde content (p <0.001) among the patients with the combinative pathology. The index of the antioxidative ability of blood serum was low in these patients (p <0.001); besides, it had the negative correlation relationship with the index of the total changes of microhemocirculation and microvasculature (r = -0.467; p <0.05). At the same time the index of ristomycin- inducted platelet aggregation as reflection of the changed endothelial function and a marker of the thrombogenic risk was also the highest in case of the comorbid course of essential hypertension (p <0.001); besides, its positive correlation relationship with the index of the total changes of microhemocirculation and microvasculature (r = +0.465; p <0.05) was established.Документ Можливі шляхи корекції деяких показників системного запалення при лікуванні хворих на гіпертонічну хворобу в умовах коморбідності(2019) Бурмак, Юрій Григорович; Петров, Євген Євгенович; Треумова, Світлана Іванівна; Іваницька, Тетяна Анатоліївна; Козленко, Тетяна Вікторівна; Бурмак, Юрий Григорьевич; Петров, Евгений Евгеньевич; Треумова, Светлана Ивановна; Иваницкая, Татьяна Анатольевна; Козленко, Татьяна Викторовна; Burmak, Yu. G.; Petrov, Ye. Ye.; Treumova, S. I.; Ivanitskaya, T. A.; Kozlenko, T. V.Мета дослідження - вивчити та проаналізувати вплив комбінованого лікування із застосуванням комбінації донатору оксиду азоту та селен-вмісного засобу на динаміку змін деяких показників системного запалення у хворих на гіпертонічну хворобу (ГХ)в умовах коморбідного перебігу із пептичною виразкою (ПВ) дванадцятипалої кишки (ДПК);Цель исследования - изучить и проанализировать влияние комбинированного лечения с применением комбинации донатора оксида азота и селен-содержащего средств на динамику изменения некоторых показателей системного воспаления у больных гипертонической болезнью (ГБ) и коморбидной пептической язвой (ПЯ) двенадцатиперстной кишки ДПК;The aim of the research was to study and analyze influence of combination treatment with using of nitrogen oxide donator and selenium-containing drug upon dynamics of the change of some systemic inflammation indices in the patients with hypertensive disease (HD) and comorbid duodenal peptic ulcer (DPU).