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Документ The Influence of Pioglitazone on NFkB Expression in CD40+ OrO Lymphocytes is Polymorphism-Dependent(Washington, 2009) Kaidashev, I. P.; Kutzenko, N.; Shlykova, O.; DuBuske, L. M.; Кайдашев, Ігор Петрович; Куценко, Н.; Шликова, Оксана АнатоліївнаExpression of CD40 cells was unchanged in control or P cul tures. Expression of NFkB in CD40-positive cells significantly increased in all control cultures after 24 hours incubation. Addition of P to MNC in duced from 5 to 25% dose-dependent decrease in NFkB expression. The impact of P on CD40+ cells with the Prol2Ala polymorphism of PPAR- 7 was greatest on MNC from patients bearing the Alal2 allele.