Перегляд за Автор "Kyrian, O."

Зараз показуємо 1 - 2 з 2
  • Ескіз недоступний
    Документ
    Evaluation of the impact of some single-nucleotide gene polymorphisms on the development of adenomatous polyps of the colon in patients with irritable bowel syndrome
    (AVES, Büyükdere Cad., 105/9 34394 Mecidiyeköy, Şişli, İstanbul, TURKEY, 2023-08-02) Kyrian, O.; Dorofeyev, A.; Derkach, I.; Zhigal, Yu.; Кир'ян, Олена Анатоліївна; Дорофєєв, Андрій Едуардович; Деркач, Ігор Анатолійович
    Background/Aims: The number of cases of irritable bowel syndrome is growing worldwide, in which adenomatous polyps can develop as a result of microinflammation of the colonic epithelium. Our study was aimed at the identification of the possible effect of singlenucleotide polymorphisms on the risk of the development of irritable bowel syndromerelated colonic adenomatous polyps. Materials and Methods: The study involved 187 irritable bowel syndrome patients. The single-nucleotide polymorphisms were investigated by the polymerase chain reaction method and DNA was extracted with the phenolchloroform: interleukin-1β gene-31C/T (rs1143627), -511C/T (rs16944); interleukin-6 gene-174G/C (rs1800795); interleukin-10 gene-592C/A (rs1800872), -819T/C (rs1800871), -1082A/G (rs1800896); Toll-like receptor-2 gene Arg753Gln (rs5743708); Toll-like receptor-4 gene Thr399ile (rs4986791), Asp299Gly (rs4986790); and metalloproteinase-9 gene-8202A/G (rs11697325). The study of polymorphic loci was checked for compliance with the Hardy–Weinberg equilibrium using Fisher’s exact test along with the analyses of the frequency of alleles and the genotypes. Results: The association of diseases with G allele Toll-like receptor-2 gene Arg753Gln (rs5743708) was revealed in irritable bowel syndrome patients with adenomatous polyps of the colon (P< .0006) and AG single-nucleotide polymorphisms s of Toll-like receptor-2 gene (χ2 = 12.78, P<.002); A allele had a protective effect. The AG genotype metalloproteinase-9 gene-8202A/G (rs11697325) poly-morphism in irritable bowel syndrome patients with adenomatous polyps of the colon had a protective effect (P<.05). AA genotype interleukin-10 gene-1082A/G (rs1800896) polymorphism in the irritable bowel syndrome patient (χ2 = 33.97,4.0E-8) can be considered as the risk for adenomatous polyps of the colon in irritable bowel syndrome. Conclusion: G allele Toll-like receptor-2 gene Arg753Gln (rs5743708) and AA genotype interleukin-10 gene-1082A/G (rs1800896) polymorphisms can be the marker of the emergence of adenomatous polyps of the colon concomitant with irritable bowel syndrome.
  • Ескіз недоступний
    Документ
    The use of role-play as a model of teaching palliative care to interns in general medical practice
    (Канадське видавництво «Акцент График Communications & Publishing», 2020-04-30) Zhdan, V.; Kyrian, O.; Dorofeyev, A.; Babanina, M.; Ждан, Вячеслав Миколайович; Кир'ян, Олена Анатоліївна; Дорофєєв, Андрій Едуардович; Бабаніна, Марина Юріївна
    Contemporary medical higher education, especially the postgraduate training of physicians, requires a creative teaching approach to train a competent health care professional. The use of interactive role-play teaching method assists in strengthening the link between practical and theoretical skills, which is especially relevant in teaching of palliative medicine. The paper is aimed at evaluation of the possibility of improving the effectiveness of the training of medical interns, using the role-play technique. To evaluate the impact of such interactive teaching methods as role- play in teaching of palliative care, we analyzed the effectiveness of teaching of 162 interns from 2014 to 2020. Subgroup I (n=82) involved medical interns who had in-class experience with role play technique. Subgroup II (n=80) involved interns for whom role-play teaching approach was not utilized. The findings of the analysis have revealed that the use of role-play teaching model in Subgroup I increased the academic success rate of interns to 94.7% (p≤0.05) in contrast to 81.3% (p≤0.2) in Subgroup II. Moreover, interns of Subgroup I rated the work of the teacher higher (8.2 points), compared to Subgroup II, where the score was 6.9 points. Therefore, the use of role-play as one of the interactive teaching methods in the postgraduate training of interns can improve the basic knowledge in patient care management in both theoretical and practical part of the training, which further improves professional progress and necessitates greater use of this method of interactive training in the postgraduate study.