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Документ A rare case of Bordetella avium pneumonia complicated by Raoultella planticola(John Wiley & Sons Ltd, 2020) Lavrenko, Anna; Digtiar, Nataliia; Gerasymenko, Nataliia; Kaidashev, Igor; Лавренко, Анна Володимирівна; Дігтяр, Наталія Іванівна; Герасименко, Наталія Дмитрівна; Кайдашев, Ігор ПетровичBordetella avium pneumonia immunocompromised the patient with subsequent complication by a rare opportunistic Raoultella planticola infection, which became a nosocomial pathogen in the healthcare setting. Пневмонія Bordetella avium знизила імунітет пацієнта з подальшим ускладненням рідкісною умовно-патогенною інфекцією Raoultella planticola, яка стала нозокоміальним патогеном у медичних закладах.Документ Etiology and efficacy of anti-microbial treatment for community-acquired pneumonia in adults requiring hospital admission in Ukraine(2022) Kaidashev, Igor; Lavrenko, Anna; Baranovskaya, Tatiana; Blazbko, Victor; Digtiar, Nataliia; Dziublyk, Oleksandr; Gerasymenko, Nataliia; Iasdyna, Liudmyla; Kryvetskyi, Volodymyr; Kuryk, Lesya; Rodionova, Viktoria; Stets, Roman; Vysbnyvetskyy, Ivan; Fesbcbenko, Yurii; Кайдашев, Ігор Петрович; Лавренко, Анна Володимирівна; Дігтяр, Наталія Іванівна; Герасименко, Наталія ДмитрівнаBackground and aim: Empiric therapy of community-acquired pneumonia (CAP) remains the standard care and guidelines are mostly based on published data from the United States or Europe. In this study, we determined the bacterial etiology of CAP and evaluated the clinical outcomes under antimicrobial treatment of CAP in Ukraine. Methods: A total of 98 adult subjects with CAP and PORT risk II-IV were recruited for the study. The sputum diagnostic samples were obtained from all patients for causative pathogen identification. Subjects were randomly assigned in a 1:1 ratio to receive delafloxacin 300 mg (n=51) or moxifloxacin 400 mg (n=47) with blinding placebo. The switch to oral treatment was after a minimum of 6 IV doses according to clinical criteria. The total duration of antibacterial treatment was 5-10 days. In vitro susceptibility of pathogens to delafloxacin and other comparator antibiotics was determined. Results: The most frequently isolated pathogens in adults with CAP were S. pneumoniae - 19.5%, M. pneumoniae - 15.3%, H. influenzae - 13.2%, S. aureus - 10.5%, K. pneumoniae - 10.1%, and H. parainfluenzae - 6.4%. All isolates of S. pneumoniae, S. aureus, M. pneumoniae had sufficient susceptibility to appropriate antibiotics. 9.0% of H. influenzae strains were susceptible to azithromycin. 94.8 % of patients had a successful clinical response to delafloxacin at the end of treatment and 93.9 % - at test-of-cure. Conclusions: In Ukraine, the major bacterial agents that induced CAP in adults were S. pneumoniae, M. pneumoniae, H. influenzae, S. aureus, K. pneumoniae, H. parainfluenzae, E. cloacae, L. pneumophila. Delafloxacin is a promising effective antibiotic for monotherapy for CAP in adults and could be used in cases of antimicrobial-resistant strains.Документ Modern aspects of the study of biomarkers in patients with diabetic kidney disease and type 2 diabetes(European Journal of Case Reports in Internal Medicine, 2023) Borzykh, Oksana; Mormol, Irina; Lavrenko, Anna; Avramenko, Yanina; Kaidashev, Igor; Борзих, Оксана Анатоліївна; Мормоль, Ірина Анатоліївна; Лавренко, Анна Володимирівна; Авраменко, Яніна Миколаївна; Кайдашев, Ігор ПетровичThe study was designed to evaluate the potential significance of the urine biomarkers for the early diagnosis and development of the personalized management plan for the patients with type 2 diabetes and associated kidney disease regardless of other complications.The study was designed to determine the significance of the modern serum and urine biomarkers for the diagnosis and development of the personalized management plan for the patients with type 2 diabetes and associated kidney disease. The initial data results confirm the importance of setting the new approaches to the early diagnosis and reasonable personalized treatment for patients with type 2 diabetes and cardio-vascular and renal complications, as this can work as an effective tool for the prevention of further complications and so the improvement of prognosis and the quality of life for such patients.Документ Topography and shapes of the cecum with intact appendix human(Medical Teacher, 2017) Gryn, Vladimir; Lavrenko, Anna; Lavrenko, Dmytro; Dubinin, Serhiy; Ryabushko, Mykola; Гринь, Володимир Григорович; Лавренко, Анна Володимирівна; Лавренко, Дмитро Олександрович; Дубінін, Сергій Іванович; Рябушко, Микола Миколайович; Гринь, Владимир Григорьевич; Лавренко, Анна Владимировна; Лавренко, Дмитрий Александрович; Дубинин, Сергей Иванович; Рябушко, Николай НиколаевичOn the basis of visual evaluation and comparative analysis of the variability metrics studied the cecum shape, character set variability the cecum topography features depending on the type of the human body. Select the shape the cecum, the analysis of its width and depth (according to the metric data)Документ Ways to improve the management of patients with kidney disease and diabetes, taking into account the associated pathology(2021) Borzykh, Oksana; Lavrenko, Anna; Avramenko, Yanina; Kaidashev, Igor; Борзих, Оксана Анатоліївна; Лавренко, Анна Володимирівна; Авраменко, Яніна Миколаївна; Кайдашев, Ігор Петрович