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Документ Assessment of endothelial dysfunction in pregnant women with obesity and preeclampsia(Wiadomości Lekarskie, 2021-08) Zelinka-Khobzey, Marta; Tarasenko, Kostiantyn; Mamontova, Tetiana; Зелінка-Хобзей, Марта Миколаївна; Тарасенко, Костянтин Володимирович; Мамонтова, Тетяна ВасилівнаThe aim: To assess the values of endothelial vascular growth factor (VEGF) in blood serum and circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women depending on the severity of obesity and presence of preeclampsia. Materials and methods: the study included 122 pregnant women divided into groups in accordance with their height and weight parameters and presence of preeclampsia. We studied the serum VEGF concentration by enzyme-linked immunosorbent assay, carried out the count of CD32+CD40+ circulating endothelial microparticles in the peripheral blood by using flow cytometry. Results: It has been found out the serum VEGF concentration in pregnant women with obesity decreases with rising level of obesity and the preeclampsia manifestation. In contrast to the decrease in this marker, there is an increase in the number of circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women with obesity and preeclampsia. This pattern of these indicators points out the presence of endothelial dysfunction, which may contribute to occurrence of preeclampsia in pregnant women with concomitant obesity. Conclusions: The indicators of VEGF concentration and the count of circulating endothelial microparticles CD32+CD40+ in the blood serum can serve as reliable markers for evaluating the severity of endothelial dysfunction in pregnant women with concomitant obesity and preeclampsia.Документ Genetic drift Sars-Cov-2 strains mutations among ukrainian population(2022) Trotsko, Serhiy; Shevchenko, Maksim; Mamontova, Veronika; Mamontova, Tetiana; Мамонтова, Тетяна ВасилівнаThe goal of investigation: assess the prevalence of mutations SarS-CoV-2 genome among the population of Ukraine. COVID-19 was declared a public health emergency of international concern. Genomic sequencing of SarS-CoV-2 structure of the virus allows to detect transmission chains, track contacts and identify new strain variants, namely variants of concern (VOC) and variants of interest (VOI), which are responsible for increasing the transmission of the virus, the formation of immune evasion and reducing the susceptibility of vaccinated individuals to infection with new strains. However, the analysis of the spread of mutations in the SarS-CoV-2 genome in Ukraine remains completely unexplored.Документ Prevention of preeclampsia in pregnant women with obesity(Journal of Education, Health and Sport, 2021-03) Zelinka-Khobzey, Marta; Tarasenko, Kostiantyn; Mamontova, Tetiana; Shlykova, Oksana; Зелінка-Хобзей, Марта Миколаївна; Тарасенко, Костянтин Володимирович; Мамонтова, Тетяна Василівна; Шликова, Оксана АнатоліївнаReducing the occurrence of preeclampsia is one of the key tasks in modern obstetrics, especially in pregnant women with concomitant obesity, who are at high risk for preeclampsia, the leading pathogenetic segment of which is endothelial dysfunction. The purpose of this work is to evaluate the effectiveness of the integrated therapeutic and preventive complex (TPC) in order to prevent preeclampsia in pregnant women. These parameters were evaluated using such markers as the concentration of vascular endothelial growth factor (VEGF) in blood serum and the content of circulating endothelial microparticles (CEM) CD32+CD40+ in peripheral blood in pregnant women with obesity of varying severity over the course of treatment we proposed. 110 pregnant women were included in the study: women with physiological body weight (n=26); women with class I obesity (n=42), and women with class II-III obesity. The groups of pregnant women with concomitant obesity were divided into two equal subgroups; one of the subgroups received the TPC (acetylsalicylic acid, calcium supplements, L-arginine, diosmin). The findings obtained demonstrate a significant improvement of endothelial status over the course of the therapy that is manifested with an increase in the serum VEGF concentration and a decrease in the content of CD32+CD40+ CEM in the peripheral blood. Our clinical assessment of pregnancy course, childbirth and the postpartum period in women with obesity and physiological body weight has shown a decrease in the occurrence of complications due to taking the integrated TPC. We have registered a decrease in the incidence of preeclampsia, placental dysfunction, occurrence of miscarriage, operative delivery and postpartum complications.