Перегляд за Автор "Moskalenko, R. A."

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    Expression of Ki67 and CD68+ cells of red bone marrow monocyte sprout under triptorelin administration in the hypothalamicpituitary-testis regulatory system: the experimental study
    (ТОВ «Ландпресс», 2023) Martynenko, R. V.; Shepitko, V. I.; Stetsuk, Ye. V.; Boruta, N. V.; Rud, M. V.; Vilkhova, O. V.; Moskalenko, R. A.; Martynenko, V. B.; Мартиненко, Роман Віталійович; Шепітько, Володимир Іванович; Стецук, Євген Валерійович; Борута, Наталія Володимирівна; Рудь, Марія Володимирівна; Вільхова, Олена Вікторівна; Москаленко, Роман Андрійович; Мартиненко, Віталій Борисович
    Red bone marrow (RBM) is the main organ of human haemopoiesis. Monocytopoiesis plays an important role in the formation of transitional states: from normal to pathology and in the transformation of pathological processes from one stage to another. In modern urological practice, the substance triptorelin is widely used for androgen deprivation therapy, according to the recommendations of the European Association of Urology. Ki67, a commercially available monoclonal antibody that reacts with a nuclear antigen detected only in proliferating cells, is used to assess immunohistochemical changes. CD68 is a valuable cytochemical marker for immunostaining of monocytes/macrophages during histochemical analysis of tissues in inflammation, cancer and other immunohistopathological purposes. The purpose of the study is to evaluate the proliferative activity and differentiation of progenitor cells through the expression of Ki67 and CD68+ monocyte sprouting of RBM under chemical castration of central origin in male rats caused by the administration of triptorelin solution with quercetin addition to the diet for one year.