Перегляд за Автор "Raskaley, V. B."

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    Reaction of rat hepatocytes during correction of acute experimental aseptic inflammation of the peritoneum by the administration of cryopreserved placenta
    (Poltava State Medical University, 2022) Voloshyna, O. V.; Shepitko, V. I.; Pelipenko, L. B.; Raskaley, V. B.; Волошина, Олена Валеріївна; Шепітько, Володимир Іванович; Пелипенко, Лариса Борисівна; Раскалєй, В. Б.
    Analyzing the results of the experimental study, it should be noted that the method of treatment of acute experimental aseptic peritonitis, which we proposed, can be attributed to the effectiveness and, in terms of performance, easily accessible, which is practically uncomplicated. The morphometric study revealed that the mean large diameter of hepatocytes, small cell diameter and their area tended to increase from the 10th day of the experiment. From the 3–5th day of the experiment, the large and small diameters of the hepatocyte nuclei slowly increased, and on the 7th and 10th days, the values were the largest. The value of the nuclear-cytoplasmic index from the 2nd to the 14th day of the experiment was greater than that of the intact group. On the 30th day of the experiment, all indices were equal to the values of the intact group.It is proved that the use of a complex of biologically active substances contained in cryopreserved placenta in acute experimental aseptic peritoneal inflammation leads to the normalization of the morphological state of hepatocytes’ structural components. When using cryopreserved placenta, the anti- inflammatory effect of biologically active substances is manifested by the restriction of alternative and increased reparative phenomena. Thus, based on this study, we can assume that the introduction of cryopreserved placenta not only implements its multiple properties, such as immunomodulatory and immunostimulatory, desensitizing, antitoxic, hepatoprotective, stimulation of regeneration but also affects its influence and reduces recovery time.