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Документ Effect of the acute total gamma radiation in a sublethal dose on the biophysical properties of red blood cells, lipid peroxidation, antioxidant supply and hemocoagulating properties of erythrocytes(2023) Zaporozhets, Tetiana; Korovina, Lidiia; Sanyk, Oleksandr; Запорожець, Тетяна Миколаївна; Коровіна, Лідія Дмитрівна; Саник, Олександр ВолодимировичThe aim of the investigation was to study the effect of acute, total gamma-irradiation in a sublethal dose on the biophysical properties of erythrocytes, the intensity of lipid peroxidation, antioxidant supply and hemocoagulating properties of erythrocytes. The experiments were carried out on 11-12-week-old age guinea pigs, males and females in equal numbers. The animals were ex- posed to a single total radiation at a dose of 4.5 Gy (sublethal dose, LD 50/30). The studies were carried out on the 7th day after exposure to radiation (at the height of radiation sickness). The development of radiation damage was accompanied by in- tense erythropoiesis and the appearance of erythrocytes with a high resistance to hemolysis and an increased sedimentation rate. After acute gamma irradiation, depletion of the antioxidant system was noted. It manifested in a decrease in the activity of superoxide dismutase of erythrocytes by 19.7% (p<0.01) and the con- centration of serum ceruloplasmin by 21.5% (p<0.01). The content of thiobarbituric acid reactive substances (TBARS) and their accumulation while the incubation of erythrocytes remained within the normal range. The erythrocytes of the irradiated animals exhibited increased procoagulant and decreased antiheparin activity, which reflects conformational changes in highly radiosensitive fatty acid chains of phospholipids in their membranes. A decrease in the fibrinolytic activity of erythrocytes in irradiated animals was found.Документ Relationship between blood pressure levels and body mass index values in 41,093 ukrainians people(Reial Acadèmia de Medicina de les Illes Balears (RAMIB), 2022) Tretiak, Natalia; Tretiak Kravchuk, Petro; Sanyk, Oleksandr; Loburets, Valeri; Altisench Jané, Bárbara; Ignacio Ramírez Manent, José; Третяк, Наталія Григорівна; Саник, Олександр Володимирович; Лобурець, Валерій ВасильовичIntroduction: Arterial hypertension and excess weight are two important public health problems that are increasingly affecting the world population, both in developed and developing countries. The aim of this study is to relate blood pressure values to body mass index (BMI) values in a group of people from Ukraine. Material and methods: Cross-sectional study in 41,093 Ukrainians in which the relationship between blood pressure and BMI was assessed. BMI is classified according to WHO criteria into 8 types ranging from underweight to type IV obesity. Results: There is a direct relationship between blood pressure values and BMI values in such a way that as BMI increases, blood pressure values increase in parallel. Age after 50 years, male sex, belonging to social class III and obesity increase the risk of presenting arterial hypertension. Conclusions: There is a relationship between BMI and blood pressure values in the Ukrainian population.