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Документ Blood gases and electrolytes under use of magnetite nanoparticles in blood loss(Полтавський державний медичний університет, 2021) Vazhnichaya, E. M.; Lutsenko, R. V.; Semaka, O. V.; Deviatkina, T. O.; Deviatkina, N. M.; Kurapov, Yu. A.; Litvin, S. Ye.; Важнича, Олена Митрофанівна; Луценко, Руслан Володимирович; Семака, Олександр Валентинович; Дев'яткіна, Тетяна Олексіївна; Дев'яткіна, Наталія Миколаївна; Курапов, Юрій Анатолійович; Литвин, Станіслав ЄгоровичBlood gases, acid-base balance, and electrolytes were studied under the conditions of correction of acute blood loss in abino rats with magnetite nanoparticles (5–8 nm) obtained by electron-beam technology and incorporated into sodium chloride crystals. It was shown that blood loss decreases total hemoglobin and the volumetric concentration of oxygen, diminishes sodium concentration and increases potassium concentration in the blood. Dissolved and injected intraperitoneally after the blood loss, magnetite nanoparticles (1.35–6.75 mg iron/kg) reduce the partial pressure of carbon dioxide, increase the partial pressure of oxygen, saturation of hemoglobin with oxygen and volumetric oxygen concentration, increase hydrogen index and sodium content, and reduce potassium concentration in the blood. These positive changes develop against the background of an increase in total hemoglobin. They surpass some effects of the traditional iron preparation and can be the basis for further research aimed at the use of magnetite nanoparticles in acute posthemorrhagic syndrome.Документ Toxicity factors of magnetite nanoparticles and methods of their research(Igor Sikorsky Kyiv Polytechnic Institute, 2024) Vazhnichaya, E. M.; Semaka, O. V.; Lutsenko, R. V.; Bobrova, N. O.; Kurapov, Yu. A.; Важнича, Олена Митрофанівна; Семака, Олександр Валентинович; Луценко, Руслан Володимирович; Боброва, Нелля Олександрівна; Курапов, Ю. А.Among nanoparticles (NPs) of metal oxides, magnetite NPs are the most well-known. The need for regulations related to the safety of magnetite NPs requires a deep understanding of their toxicological paradigm. The purpose of the presented review is to analyze the methods of studying the magnetite NPs toxicity and to summarize their toxicity factors based on the literature data. Literature sources were searched in the PubMed database, and 99 works were selected, supplemented with articles from other databases in some cases. It is shown that the study of the magnetite NPs toxicity became widespread during the last decade, reflecting the expansion of the list of synthesized magnetic NPs and the awareness that the prospects for their use depend on the safety of the created nanomaterial. The safety assessment of magnetite NPs on cell lines is the most popular. Primitive and more highly organized animals can be used to evaluate various aspects of the magnetite NPs toxicity. The toxicity factors of magnetite NPs depend on their characteristics (core composition, coating, size, and shape) and the mode of application (concentration, dose, exposure, type of cells, or animal model). One of the main mechanisms of nanomagnetite toxicity is the interference with iron metabolism and increased generation of reactive oxygen species leading to the disruption of cell proliferation, viability, and metabolism. Thus, the toxicity of magnetite NPs is studied by various methods and at different levels of living systems. Understanding the mechanisms of nanotoxicity should contribute to the targeted design of safe magnetic NPs.