Перегляд за Автор "Shkodina, Anastasiia D."

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    Immunological and inflammatory effects of infectious diseases in circadian rhythm disruption and future therapeutic directions
    (Springer, 2023-01-19) Huang, Helen; Mehta, Aashna; Jacob, Kalmanovich; Anand, Ayush; Bejarano, Maria Chilo; Garg, Tulika; Khan, Nida; Тonpouwo, Gauvain Kankeu; Shkodina, Anastasiia D.; Bardhan, Mainak; Шкодіна, Анастасія Дмитрівна
    Background Circadian rhythm is characterised by daily variations in biological activity to align with the light and dark cycle. These diurnal variations, in turn, influence physiological functions such as blood pressure, temperature, and sleep–wake cycle. Though it is well established that the circadian pathway is linked to pro-inflammatory responses and circulating immune cells, its association with infectious diseases is widely unknown. Objective This comprehensive review aims to describe the association between circadian rhythm and host immune response to various kinds of infection. Methods We conducted a literature search in databases Pubmed/Medline and Science direct. Our paper includes a comprehensive analysis of findings from articles in English which was related to our hypothesis. Findings Molecular clocks determine circadian rhythm disruption in response to infection, influencing the host’s response toward infection. Moreover, there is a complex interplay with intrinsic oscillators of pathogens and the influence of specific infectious processes on the CLOCK: BMAL1 pathway. Such mechanisms vary for bacterial and viral infections, both well studied in the literature. However, less is known about the association of parasitic infections and fungal pathogens with circadian rhythm modulation. Conclusion It is shown that bidirectional relationships exist between circadian rhythm disruption and infectious process, which contains interplay between the host’s and pathogens’ circadian oscillator, immune response, and the influence of specific infectious. Further studies exploring the modulations of circadian rhythm and immunity can offer novel explanations of different susceptibilities to infection and can lead to therapeutic avenues in circadian immune modulation of infectious diseases.
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    Документ
    Prospective pilot study to assess motor activity and the state of the hemostasis system in the acute period of ischemic stroke during systemic thrombolytic therapy
    (Aluna Publishing, 2021) Havlovska, Yaroslava Yu.; Lytvynenko, Nataliya V.; Havlovskyi, OIeksandr L.; Shkodina, Anastasiia D.; Гавловська, Ярослава Юріївна; Литвиненко, Наталія Володимирівна; Гавловський, Олександр Леонідович; Шкодіна, Анастасія Дмитрівна
    OBJECTIVE: The aim: To investigate changes in motor activity and indicators of the state of the hemostasis system in the acute period of ischemic stroke during systemic thrombolytic therapy and without its use. PATIENTS AND METHODS: Materials and methods: We examined 26 male and female patients with a clinical diagnosis of ischemic stroke, who were hospitalized on the first day of the disease to the neurological departments. Patients were divided into 2 groups: group 1-patients who underwent systemic thrombolytic therapy (sTLT) (n=11), group 2-patients who did not receive sTLT (n=15). To compare the coagulogram parameters, 12 healthy patients were examined (control group). Examination of patients was performed on the 1st and 14th day of the disease (clinical examination, assessment of motor activity, coagulation test). Stroke severity was determined by the overall score of the National Institutes of Health Stroke Scale. RESULTS: Results: The average age of patients in group 1 - 60.1±8.2 years old, in group 2 -61.3±5.5 years old. The number of points on the NIHSS scale in group 1 was 8.8±1.13 on 1st day and 3.7±0.79 on 14th day (p<0.05), in group 2 -5.7±0,94 on the 1st day and 3.1±0.93 on the 14th day(p<0.05). The results of the study of the coagulogram indicate a significantly higher level of soluble fibrin-monomer complexes on the 1st day on the 14th day of the ischemic stroke. CONCLUSION: Conclusions: In the acute period of ischemic stroke changes in the hemostasis system reflected the direction of the selected therapy. The use of systematic thrombolytic therapy in ischemic stroke led to a more severe decrease in stroke severity on the NIHSS scale, a significant increase in Barthel index.