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Документ Difficulties in Diagnosis of Sialolithiasis: A Case Series(Tokyo Shika Daigaku, 2018) Kolomiets, S.; Udaltsova, K.; Khmil, T.; Yelinska, A.; Pisarenko, O.; Shynkevych, V.; Коломієць, Світлана Веніамінівна; Удальцова, Кристина Олександрівна; Хміль, Тетяна Андріївна; Єлінська, Аліна Миколаївна; Писаренко, Олена Анатоліївна; Шинкевич, Вікторія ІгорівнаSialolithiasis is one of the most common and extensively obstructive disorders of the major salivary glands. Here, we report 3 cases of sialolithiasis in the submandibular salivary gland showing symptomatic similarities to other dental and non-dental disorders of the maxillofacial area. How the various clinical features of this condition and fndings on 3D-CT may lead to a misdiagnosis are also discussed. In the frst case, that of a 45-year-old woman, a fnal diagnosis of a non-radiopaque submandibular sialolith allowed the initially indicated surgical extraction of a malerupted and semi-impacted right mandibular 3rd molar to be abandoned. In the second case, that of a 57-year-old woman, radiographic fndings had previously led to a diagnosis of ameloblastoma, which had masked the presence of sialolithiasis for at least 9 years, despite the radiopacity of the sialolith. Meanwhile, exacerbation of sialolithiasis was mistaken for lymphadenitis. In the third case, that of a 40-year-old woman, sialolithiasis was diagnosed in a timely manner, despite the fact that the dentists’ attention had initially been focused on odontopathological symptoms. One feature of the present report is the concurrence of dental and non-dental pathologies affecting the same sextant as the sialolithiasis. Despite recent advances in imaging technology and diagnostics, cases of sialolithiasis being misdiagnosed continue to occur inclinical practice.Документ PPAR-γ agonist pioglitazone restored mouse liver m RNA expression of clock genes and inflammation-related genes disrupted by reversed feeding(Hindawi, 2022) Fedchenko, T.; Izmailova, O.; Shynkevych, V.; Shlykova, O.; Kaidashev, I.; Федченко, Тетяна Юріївна; Ізмайлова, Ольга Віталіївна; Шинкевич, Вікторія Ігорівна; Шликова, Оксана Анатоліївна; Кайдашев, Ігор ПетровичThe master clock, which is located in the suprachiasmatic nucleus (SCN), harmonizes clock genes present in the liver to synchronize life rhythms and bioactivity with the surrounding environment. The reversed feeding disrupts the expression of clock genes in the liver. Recently, a novel role of PPAR-γ as a regulator in correlating circadian rhythm and metabolism was demonstrated. This study examined the influence of PPAR-γ agonist pioglitazone (PG) on the mRNA expression profile of principle clock genes and inflammation-related genes in the mouse liver disrupted by reverse feeding. Methods. Mice were randomly assigned to daytime-feeding and nighttime-feeding groups. Mice in daytime-feeding groups received food from 7 AM to 7 PM, and mice in nighttime-feeding groups received food from 7 PM to 7 AM. PG was administered in the dose of 20 mg/kg per os as aqueous suspension 40 μl at 7 AM or 7 PM. Each group consisted of 12 animals. On day 8 of the feeding intervention, mice were sacrificed by cervical dislocation at noon (05 hours after light onset (HALO)) and midnight (HALO 17). Liver expressions of Bmal1, Clock, Rev-erb alpha, Cry1, Cry2, Per1, Per2, Cxcl5, Nrf2, and Ppar-γ were determined by quantitative reverse transcription PCR. Liver expression of PPAR-γ, pNF-κB, and IL-6 was determined by Western blotting. Glucose, ceruloplasmin, total cholesterol, triglyceride concentrations, and ALT and AST activities were measured in sera by photometric methods. The null hypothesis tested was that PG and the time of its administration have no influence on the clock gene expression impaired by reverse feeding. Results. Administration of PG at 7 AM to nighttime-feeding mice did not reveal any influence on the expression of the clock or inflammation-related genes either at midnight or at noon. In the daytime-feeding group, PG intake at 7 PM led to an increase in Per2 and Rev-erb alpha mRNA at noon, an increase in Ppar-γ mRNA at midnight, and a decrease in Nfκb (p65) mRNA at noon. In general, PG administration at 7 PM slightly normalized the impaired expression of clock genes and increased anti-inflammatory potency impaired by reversed feeding. This pattern was supported by biochemical substrate levels—glucose, total cholesterol, ALT, and AST activities. The decrease in NF-κB led to the inhibition of serum ceruloplasmin levels as well as IL-6 in liver tissue. According to our data, PG intake at 7 PM exerts strong normalization of clock gene expression with a further increase in Nrf2 and, especially, Ppar-γ and PPAR-γ expression with inhibition of Nfκb and pNF-κB expression in daytime-feeding mice. These expression changes resulted in decreased hyperglycemia, hypercholesterolemia, ALT, and AST activities. Thus, PG had a potent chronopharmacological effect when administered at 7 PM to daytime-feeding mice. Conclusions. Our study indicates that reversed feeding induced the disruption of mouse liver circadian expression pattern of clock genes accompanied by increasing Nfκb and pNF-κB and IL-6 expression and decreasing Nrf2 and PPAR-γ. Administration of PG restored the clock gene expression profile and decreased Nfκb, pNF-κB, and IL-6, as well as increased Nrf2, Ppar-γ, and PPAR-γ expression. PG intake at 7 PM was more effective than at 7 AM in reversed feeding mice.Документ Взаємозв’язок імунопатогенезу хронічного генералізованого пародонтиту із гістологічними особливостями ясен(Вищий державний навчальний заклад України «Українська медична стоматологічна академія», 2008) Шинкевич, Вікторія Ігорівна; Шинкевич, Виктория Игоревна; Shynkevych, V.Дослідження та краще розуміння патогенетичних ланок при хронічному генералізованому пародонтиті (ХГП) є актуальною проблемою. Імунні клітини при ХГП входять до складу інфільтратів у locus morbi, беруть участь в патогенезі. Однак, їх вплив на морфологічні особливості пародонту визначають не лише механізми запалення і тканинної деградації. Імуноцити виконують роль у підтриманні нормальної будови, росту, диференціювання, регенерації тканин. Отже, в роботі проаналізовано можливі взаємозв’язки імунних процесів та гістологічних особливостей ясен при ХГП. Результати показали нерівнозначність локальних імунних процесів у відповідності до І-ІІІ ступенів тяжкості ХГП. Перебудова тканин внаслідок імунних процесів, на фоні прогресування захворювання вкладається у поняття ремоделювання пародонту; Углубленное исследование патогенетических звеньев при хроническом генерализованном пародонтите (ХГП) является актуальной проблемой стоматологии. Иммунные клетки при ХГП представлены в ифильтратах locus morbi, принимают участие в патогенезе заболевания. Тем не менее, их влияние на морфологические особенности тканей пародонта не ограничивается механизмами воспаления. Иммунные клетки играют роль в поддержании нормальной структуры, роста, дифференцировки, регенерации тканей. Поэтому, задача состояла в анализе возможных взаимосвязей иммунных процессов и гистологических особенностей десны при ХГП. Результаты показали зависимость локальных иммунных процессов соответственно І-ІІІ степеням тяжести заболевания. Перестройка тканей вследствие имунных процессов, на фоне прогрессирования ХГП соответствует понятию ремоделирование пародонта; Thorough study of pathogenetic chains under chronic generalized parodontitis (CGP) is one of the urgent dental problems. Immune cells under CGP are represented in locus morbi infiltrates and participate in pathogenesis of the disease. Nevertheless their influence upon the morphological characteristics of peridontal tissues is not cut down with inflammatory mechanisms. Immune cells play an important role in maintenance of normal structure, differentiation, regeneration of tissues. Therefore, the task consisted in the analysis of possible interrelations of immune processes and histological peculiarities of gums under CGP. The results have shown the interdependence between local immune processes and I-III degrees of disease severity accordingly. Tissue changes resulted from the immune processes against CGP progressing correspond to the conception of periodontium remodeling.