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Документ Значення окремих імуногенетичних факторів крові у формуванні тиреоїдного статусу та ліпідному обміні за умов пролонгованого впливу малих доз радіації(Українська медична стоматологічна академія, 2017) Соколенко, В. Л.; Соколенко, С. В.; Sokolenko, V. L.; Sokolenko, S. V.Досліджували значення еритроцитарних систем АВ0 та Rhesus, а також сироваткової системи гаптоглобінів у формуванні тиреоїдного статусу та ліпідному обміні за умов пролонгованого впливу малих доз радіації. Встановили, що у контрольній групі аналізовані імуногенетичні фактори беруть певну участь у регуляції обміну ліпідів і практично не впливають на тиреоїдний статус. У осіб з радіаційно забруднених територій нівелюється можливість включення даних факторів у регуляцію ліпідного обміну, що свідчить про порушення адаптаційних можливостей у даної категорії населення; Исследовали значение эритроцитарных систем АВ0 и Rhesus, а также сывороточной системы гаптоглобина в формировании тиреоидного статуса и липидном обмене в условиях пролонгированного влияния малых доз радиации. Установили, что в контрольной группе анализируемые иммуногенетические факторы принимают определенное участие в регуляции обмена липидов и практически не влияют на тиреоидный статус. У лиц из радиационно-загрязненных территорий нивелируется возможность включения данных факторов в регуляцию липидного обмена, что свидетельствует о нарушении адаптационных возможностей в данной категории населения; We studied the meaning of some immunogenetic blood factors in forming of thyroid status and lipid metabolism under conditions of prolonged impact of low dose radiation. There are many evidences that the immunogenetic factors of blood can play an important role in different humandiseases. However, the results are often contradictory. It is believed that the problem of interpretation of the consequences of the research is the presence of a number of related factors. In particular, the strength and severity of manifestation of immunogenetic factors may be influenced by geographical, epigenetic, environmental factors, socio-economic living conditions, which are able to lead to increased emotional stress. We have analyzed the data of 170 students of National University of Cherkasy, aged 18-24, including control group of 70 persons. The rest are residents of areas of enhanced radiation monitoring (IV radiation zone, the density of soil contamination with isotopes 137Cs is 3.7 104 – 18.5 104 Bq/m2), 100 people. All examined at the time of research not having any acute diseases. We determined the level of thyroid stimulating hormone (TSH), thyroxine (T4) and triiodothyronine (T3), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c) in blood serum. We also studied the phenotype of immunogenetic systems AB0, Rh (Rhesus) and Hp (haptoglobin). The received data of the control group are largely consistent with the literature; however, the implementation of immunogenetic factors impact on lipid metabolism is realized only under additional emotional stress. Individuals in the control group with the phenotypes A(II), Rh- and Hp 2-2 under the conditions of emotional stress prove to have the higher level of cholesterol and LDL cholesterol. The identified features may be caused to the fact that the respondents belonged to a group of healthy. There was no variability indices of thyroid status in persons with analyzed immunogenetic systems of blood. This is consistent with data about the lack of clear communications thyroid dysfunction with various serological markers. Analysis of lipid metabolism and thyroid status of residents in areas contaminated with radionuclides showed no variation depending on the analyzed genetic factors. This feature was observed before and during emotional stress. At the same time, the patients who had undergone a prolonged effect of low doses of ionizing radiation, regardless of immunogenetic phenotype had significantly higher level of total cholesterol, triglycerides, HDL and LDL cholesterol as compared with controls. LDL cholesterol level is above the limit of homeostatic regulations and significantly increases during emotional stress. Emotional stress also leads to a significant increase (with going above the limit of normal) of total cholesterol and reduction of HDL cholesterol. Thus, immunogenetic erythrocytic system AB0 and Rhesus, and serum haptoglobin system take part in controlling lipid metabolism and have almost no effect on thyroid status. People who long lived in the areas contaminated with radionuclides, analyzed blood immunogenetic factors possibility is levelled in the regulation of lipid metabolism. This proves a violation of regulatory adaptive capacities with chronic exposure of low doses of ionizing radiation. Changes in the concentration of certain lipid fractions from going beyond the limits of homeostatic regulations make inhabitants of the strengthened radiation monitoring territory to be the risk group of the lipid metabolism violation with possible underlying cardiovascular diseases.Документ Значення статевого фактора у реалізації окремих показників імунної, ендокринної систем та ліпідного обміну за умов пролонгованого впливу малих доз радіації(Українська медична стоматологічна академія, 2017) Соколенко, В. Л.; Соколенко, С. В.; Sokolenko, V. L.; Sokolenko, S. V.Досліджували значення статевого фактора у реалізації окремих показників імунної, ендокринної систем та ліпідного обміну за умов пролонгованого впливу малих доз радіації. Встановили, що в осіб, котрі тривалий час проживали на територіях, забруднених радіонуклідами, відсутня статистично вірогідна статева варіативність аналізованих показників (у тому числі, при додатковому психоемоційному навантаженні). Це може бути ознакою вичерпування адаптаційних можливостей організму, зумовленого пролонгованим радіаційним впливом, і нівелювання значення статевого фактора у імунонейроендокринній регуляції; Исследовали значение полового фактора в реализации отдельных показателей иммунной, эндокринной систем и липидного обмена в условиях пролонгированного воздействия малых доз радиации. Установили, что у лиц, длительное время проживавших на территориях, загрязненных радионуклидами, отсутствует статистически достоверная половая вариативность анализируемых показателей (в том числе, при дополнительной психоэмоциональной нагрузке). Это может быть признаком истощения адаптационных возможностей организма, обусловленного пролонгированным радиационным воздействием, и нивелирования значения полового фактора в иммунонейроэндокринной регуляции; A considerable part of Ukraine’s territory is contaminated with long-lived radionuclide 137Cs, and so, people living there from birth, suffer chronic affection of low dose radiation. There are few data on gender dimorphism in vital activities of various physiological systems of this group and so, they require further analysis. The importance of gender factor in realization of significant parameters of the immune, endocrine systems and lipid metabolism in conditions of prolonged effect of low dose radiation was investigated. The research involved 83 males and 117 females (who were examined in the follicular phase of the menstrual cycle), the inhabitants of enhanced radiation monitoring area (IV radiation zone, the density of soil contamination with isotopes 137Cs is 3.7∙104 - 18.5∙104 Bq/m2). All examined are the students of Cherkassy State University, aged 18-24 years, at the time of research not having any acute diseases. We determined the leukocyte formula, phagocytic activity, major subpopulations of lymphocytes of the peripheral blood, levels of serum immunoglobulins and cortisol, cholesterol, TSH, thyroxine (T4) and triiodothyronine (T3). No statistically significant difference between the analyzed immune system parameters among patients of different sexes from the areas of enhanced radiation monitoring was marked. Such regularity is typical in both the absence and presence of emotional stress caused by the winter examinations. Perhaps gender-caused variation in immune system parameters appears either in the cases of severe abnormalities, or during stressful effects of higher intensity. During earlier studies in 1995-2000 any significant difference of total cholesterol and cortisol in peripheral blood of examined of both sexes was not found. In 2010-2016 the tendency for growth in total cholesterol in females was marked. Under the influence of emotional stress cortisol level increased, regardless of the gender of the patients, total cholesterol showed a rising trend. A significant difference in both parameters between examined men and women did not appear. In our studies we revealed a wide variation of thyroid profile parameters, perhaps, this caused the absence of significant difference between TSH, T3 and T4 levels in the examined of both sexes (before emotional stress, and during it). Within the groups with the symptoms of euthyroidism and hypothyroidism the correlation of men and women was almost equal, within a group with symptoms of hyperthyroidism, the rate of males was slightly higher (56%). Thus, there is no statistically significant gender variation in the analyzed parameters of immune and thyroid systems and cholesterol level in peripheral blood (also under conditions of additional emotional stress) within examined people who long lived in the areas contaminated with radionuclides and suffered chronic effects of low doses of ionizing radiation. On the one hand, it may indicate an absence of severe pathologies in patients, since, according to the literature, under such circumstances gender differences in analyzed parameters become more apparent. On the other hand, a discovered effect could be a sign of body’s adaptive capacities depletion, which was caused by prolonged radiation exposure, and also the leveling gender factor’s importance in immunoneuroendocrine regulation.