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Документ Biomarker and echocardiographic characteristics of heart failure in patients having acute myocardial infarction combined with diabetes mellitus of type 2(Aluna Publishing, 2022-04) Spivak, Yu. A.; Lyulka, N. O.; Potyazhenko, M. M.; Vakulenko, K. E.; Dubrovinska, T. V.; Співак, Юлія Анатоліївна; Люлька, Надія Олександрівна; Потяженко, Максим Макарович; Вакуленко, Костянтин Євгенійович; Дубровинська, Тетяна ВолодимирівнаThe aim: To investigate the level of B-type natriuretic peptide (BNP) and to establish its relationship with structural and functional indicators of the myocardium in patients having acute myocardial infarction (AMI), which is complicated by heart failure (HF) with concomitant type 2 diabetes mellitus (DM2).Materials and methods: The study included 120 patients who were grouped by clinical diagnosis. Every patient underwent transthoracic echocardiography of the heart: left ventricular (LV) ejection fraction (EF), left ventricular myocardial mass index (LVMI), LV relative wall thickness (LVWT), BNP, HbA1c.Results: LV EF was statistically significantly lower in group 2 compared with group 1. A significant difference was found. Significant difference between LVWT within indicators of groups 1 and 2 was found. There was a statistically significant increase of the LVMI in group 2 compared to group 1. Against the background of AMI, the formation of eccentric LVH prevailed in 61% cases. There was a statistically significant increase in BNP within the group of patients suffering of AMI with HF and concomitant DM2.Conclusions: There was found a statistically significant increase in BNP in patients suffering of AMI with HF and concomitant DM2, which indicates a significant degree of damage to cardiomyocytes and causes an aggravating course of HF. The relationship between BNP and LV EF was revealed , which can be used to prognostic the severity of HF in this category of patients. A strong correlation between BNP and HbA1 was discovered, which indicates a burdensome unity of metabolic disorders that accelerate the development and progression of HF.Документ Treatment optimisation of heart failure in patients with acute myocardial infarction and concomitant type 2 diabetes mellitus(Полтавський державний медичний університет, 2022) Spivak, Yu. A.; Potyazhenko, М. М.; Lyulka, N. O.; Vakulenko, K. Ye.; Nos, Ya. V.; Співак, Юлія Анатоліївна; Потяженко, Максим Макарович; Люлька, Надія Олександрівна; Вакуленко, Костянтин Євгенійович; Нос, Ярослава ВіталіївнаThe course and consequences of acute myocardial infarction define concomitant diseases, particularly type 2 diabetes mellitus. The primary purpose was to estimate the efficiency of eplerenone in treating heart failure in patients with acute myocardial infarction and type 2 diabetes mellitus. Two groups and two subgroups were formed. Patients underwent general clinical examinations, troponin I, brain natriuretic peptide, and glycosylated hemoglobin. It was found that patients with myocardial infarction and type 2 diabetes mellitus have a significantly higher brain natriuretic peptide level in the blood. In using an optimized treatment scheme, a decrease in the level of the natriuretic peptide was noted in patients without diabetes during the third visit compared to the first and second. Significant differences in brain natriuretic peptide concentrations at different patient visits were found in patients with comorbidities (р=0.037). The appointment of eplerenone to standard therapy for patients with myocardial infarction with and without comorbid pathology has a positive effect on the efficiency of treatment and the course of heart failure, which is confirmed by a decrease in brain natriuretic peptide as one of the leading indicators of the effectiveness of treatment of heart failure progression.