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Документ Circadian rhythm disorders and non-motor symptoms in different motor subtypes of Parkinson's disease(Georgian Association of Business Press, 2021) Tarianyk, Kateryna A.; Shkodina, Anastasiia D.; Lytvynenko, Nataliya V.; Таряник, Катерина Анатоліївна; Шкодіна, Анастасія Дмитрівна; Литвиненко, Наталія ВолодимирівнаThe phenotype of the disease depends not only on the prevalence of certain motor signs, but also on non-motor symptoms. Determination of different profiles of Parkinson's disease improves disease prognosis and management. A clinical study was conducted in patients with Parkinson's disease. For this purpose, 64 patients with various motor subtypes of the disease were examined. Diagnosis was made according to the UK Brain Bank Criteria. The patients were divided into groups according to the motor subtype verified by the results of interference electroneuromyography. In each group, demographic data were collected, staging according to the Hoehn-Yahr scale and the overall score of the unified UPDRS scale were studied. The study of gait was evaluated using the Nonmotor Symptom Rating Scale for Parkinson's Disease (NMSS). The Munich Chronotype Questionnaire (MCTQ) was used to determine sleep onset, wake-up time, sleep duration, mid-sleep, average sleep duration, average weekly light exposure, chronotype, and for working patients, relative jet lag and average weekly sleep deficit. Circadian rhythm disorders were diagnosed according to the international classification of sleep disorders-3. Patients with Parkinson's disease have a more characteristic evening chronotype and a shorter sleep duration due to late sleep onset. On the other hand, the tendency towards the morning or evening chronotype is not associated with the severity of the disease or the level of daytime sleepiness. It was found that PD patients are characterized by more pronounced disorders of the gastrointestinal, genitourinary systems, sleep and cognitive-affective disorders, and others. In patients with a mixed motor subtype, mood and cognitive impairments are more pronounced, and gait disorders are more pronounced in patients with a mixed motor subtype. Thus, different motor subtypes of Parkinson's disease have differences in the severity of motor manifestations and features of the circadian rhythm. Circadian dysregulation is associated with features of daily functioning and disorders of the motor sphere.Документ Cognitive and affective disturbances in patients with Parkinson's disease: Perspectives for classifying of motor/neuropsychiatric subtypes(Elsevier, 2022-06) Shkodina, Anastasiia D.; Tarianyk, Kateryna A.; Boiko, Dmytro I.; Zehravi, Mehrukh; Akter, Shamima; Ashraf, Ghulam Md.; Rahman, Md. Habibur; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро ІвановичParkinson’s disease (PD) is a neurological disorder, related to rigidity, bradykinesia, and resting tremors, among other motor symptoms. It is noticed in the increasing frequency of neuropsychiatric disorders, which may be also caused by non-motor symptoms of PD. Treatment of PD is usually based on the classification of motor subtypes; however, it remains unclear whether motor subtypes have differences in the severity of psychiatric symptoms. It determines the importance of discovering possible neuropsychiatric subtypes of PD. We conducted a clinical study, which included group 1 - patients with postural instability and gait disorders dominant (PIGD) subtype, group 2 - patients with tremor dominant (TD) and indeterminate subtypes (non-PIGD), and group 3 - people who did not have CNS damage. We used the Montreal Cognitive Assessment, Russified 20-point version of the Toronto Alexithymia Scale, State-Trait Anxiety Inventory, and Beck Depression Inventory for assessment of the mental status. It was the first time that neuropsychiatric subtypes of PD had been investigated based on the condition of cognition and mood. Cluster analysis gave us the possibility to classify our patients by the following subtype: affective-cognitive PIGD, anxious PIGD, affective-cognitive non-PIGD, and non-PIGD without psychiatric symptoms. This indicates a closed link between psychiatric and motor symptoms, which can be used for the improved treatment of PD.Документ Relationship between Sleep Disorders and Neuropsychiatric Symptoms in Parkinson's Disease: A Narrative Review(2022-10) Shkodina, Anastasiia D.; Iengalychev, Tymur R.; Tarianyk, Kateryna A.; Boiko, Dmytro I.; Lytvynenko, Nataliia V.; Skrypnikov, Andrii M.; Шкодіна, Анастасія Дмитрівна; Таряник, Катерина Анатоліївна; Бойко, Дмитро Іванович; Литвиненко, Наталія Володимирівна; Скрипніков, Андрій МиколайовичAim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completeness of the review, a second, more in-depth literature search was performed using the same electronic database with the search inquiries of increased specificity. Results: The information on pathophysiology, epidemiology, clinical features and risk factors was extracted and formed the basis for this review. Despite how widespread sleep disorders in Parkinson’s disease are, there is no systematic information about their association with neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment and psychosis. In this review, we described relationships between these non-motor symptoms of Parkinson’s disease, their timeline occurrence, gap in knowledge and perspectives for further research. We suppose that early treatment of sleep disorders in patients with Parkinson’s disease can reduce the incidence and extent of neuropsychiatric symptoms. Conclusion: We have demonstrated multiple, multidirectional relationships between sleep disorders and neuropsychiatric symptoms. However, some of them remain unexplored. The described knowledge can be applied to further study the possibility of influencing neuropsychiatric symptoms through the correction of sleep disorders in patients with different stages of Parkinson’s disease.Документ The role of circadian regulation of ghrelin levels in Parkinson's disease (literature review)(Aluna Publishing, 2021) Tarianyk, Kateryna A.; Lytvynenko, Nataliya V.; Shkodina, Anastasiia D.; Kaidashev, Ihor P.; Таряник, Катерина Анатоліївна; Литвиненко, Наталія Володимирівна; Шкодіна, Анастасія Дмитрівна; Кайдашев, Ігор ПетровичThe paper is aimed at the analysis of the role of the circadian regulation of ghrelin levels in patients with Parkinson's disease. Based on the literature data, patients with Parkinson's disease have clinical fluctuations in the symptoms of the disease, manifested by the diurnal changes in motor activity, autonomic functions, sleep-wake cycle, visual function, and the efficacy of dopaminergic therapy. Biological rhythms are controlled by central and peripheral oscillators which links with dopaminergic neurotransmission - core of the pathogenesis of Parkinson`s disease. Circadian system is altered in Parkinson`s disease due to that ghrelin fluctuations may be changed. Ghrelin is potential food-entrainable oscillator because it is linked with clock genes expression. In Parkinson`s disease this hormone may induce eating behavior changing and as a result metabolic disorder. The "hunger hormone" ghrelin can be a biomarker of the Parkinson's disease, and the study of its role in the pathogenesis, as well as its dependence on the period of the day, intake of levodopa medications to improve the effectiveness of treatment is promising.