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Документ Features of the clinical course of psoriasis in patients with obesity(International Science Group, 2020) Yemchenko, Ya.; Vasylieva, K.; Bezeha, O.; Ємченко, Яна Олександрівна; Васильєва, Катерина Володимирівна; Безега, Олена ВікторівнаPsoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic bias, characterized by hyperproliferation of epidermal cells, impaired keratinization due to inflammatory reaction in the dermis, as well as the lesions of nails and joints [1]. According to the results of clinical and epidemiological studies, about 3-4% of the population of our planet, regardless of gender, age and ethnic group, suffers from psoriasis, and the share of this pathology in the general structure of skin diseases, according to various authors, ranges from 1% to 40 % [2]. However, despite the considerable spread of psoriasis and a large amount of research on this problem, there is still no single view of the pathogenesis of this dermatosis. In order to objectively understand the pathogenesis of psoriasis, it is necessary to take into account the understudied comorbidity of this disease [3].Документ Features of the clinical course of psoriasis patients with grade I-II alimentary obesity(International Science Group, 2020) Yemchenko, Ya.; Vasylieva, K.; Bezeha, O.; Ємченко, Яна Олександрівна; Васильєва, Катерина Володимирівна; Безега, Олена ВікторівнаPsoriasis is one of the most common chronic recurrent multifactorial diseases of the skin with a predominance of genetic bias, characterized by hyperproliferation of epidermal cells, impaired keratinization due to inflammatory reaction in the dermis, as well as the lesions of nails and joints. According to the results of clinical and epidemiological studies, about 3-4% of the population of our planet, regardless of gender, age and ethnic group, suffers from psoriasis [2,15]. However, despite the considerable spread of psoriasis and a large amount of research on this problem, there is still no single view of the pathogenesis of this dermatosis. In order to objectively understand the pathogenesis of psoriasis, it is necessary to take into account the understudied comorbidity of this disease.Документ The effectiveness of the use of flavonoids in the complex treatment of psoriasis in patients with grade I-II alimentary obesity(International Science Group, 2020) Yemchenko, Ya.; Vasylieva, K.; Bezeha, O.; Ємченко, Яна Олександрівна; Васильєва, Катерина Володимирівна; Безега, Олена ВікторівнаPsoriasis is one of the chronic dermatoses with unexplained pathogenesis and significant prevalence among the population. Chronic and often severe course of the disease leads to disability, and sometimes to disability [1]. The lack of a clear understanding of the etiology and pathogenesis makes it possible to attribute this dermatosis to the most important medical and economic health problems [8]. It is believed that psoriasis refers to genetically determined diseases with predominant skin damage, which is associated with impaired keratinocyte proliferation and the development of inflammatory processes [2]. An undoubted relationship between psoriasis and obesity has been established [3]. In the literature, the question of identical pathogenetic mechanisms of inflammatory processes in psoriasis and obesity, forming a vicious circle at the level of the immune system, which must be broken for the successful treatment of these diseases, is widely covered [4]. Obesity can be either an independent multifactorial disease - primary obesity (alimentary-constitutional), or the syndrome accompanying the course of other diseases - secondary obesity (symptomatic). In the structure of morbidity, primary obesity occurs in 95% of patients, secondary - only in 5% [7,9]. A person is considered obese if the body mass index (BMI) exceeds 30 kg / m². According to the results of previous studies, we found that alimentary obesity in patients with psoriasis leads to metabolic disorders complicating the course of dermatosis, leading to the ineffectiveness of standard methods of therapy and frequent exacerbations of psoriatic disease [5].