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Risk markers of reproductive loss in women with hyperandrogenism
(Aluna Publishing, 2024-12) Semeniuk, L. M.; Likhachov, V. K.; Yuzvenko, T. Y.; Dobrovolska, L. M.; Makarov, O. G.; Семенюк, Людмила Миколаївна; Ліхачов, Володимир Костянтинович; Юзвенко, Тетяна Юріївна; Добровольська, Людмила Миколаївна; Макаров, Олег Геннадійович
Introduction: The frequency of the pathological course of pregnancy with hyperandrogenism ranges from 21 to 48%. With the predominance of androgens against the background of lowering the normal products of steroidogenesis, a pro-inflammatory immune imbalance is formed, which causes a premature termination of the development of pregnancy. Many studies indicate that hyperandrogenism is a factor in the development of obstetric pathology, including placental dysfunction. The severity of obstetric complications of pregnancy in women with hyperandrogenism depends on the duration of the disease and the quality of preparation for pregnancy. Establishing early markers of endocrine hyperandrogenic imbalance in the body of a future mother and conducting timely therapy is the key to the successful completion of pregnancy. The aim: the establishment of hormonal-immunological changes and morphological and receptive structure peculiarities of the endometrium correlations in women with PCOS at the pregnancy planning stage.