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Документ Ефективність лікувальних заходів у пацієнтів із генералізованим пародонтитом на тлі цукрового діабету i типу з кардіоміопатією за окремими показниками ротової рідини(Українська медична стоматологічна академія, 2017) Заболотний, Т. Д.; Кордіяк, О. Й.; Шкребнюк, Р. Ю.; Zabolotnyj, T. D.; Kordiyak, O. I.; Shkrebnyuk, R. Y.Проаналізовано ефективність лікувальних заходів у пацієнтів із генералізованим пародонтитом на тлі цукрового діабету І типу з кардіоміопатією на зміни вмісту концентрацій ендотеліну-1 і метаболітів азоту в ротовій рідині в результаті застосування запропонованої авторами схеми в основній групі та в людей групи контролю, де лікування стоматологічної хвороби проводили за загальноприйнятою методикою. Доведено, що в пацієнтів основної групи внаслідок лікування суттєво підвищився вміст метаболітів азоту на тлі зниження концентрації ендотеліну-1 у ротовій рідині в порівнянні з даними в контролі; Проанализирована эффективность лечебных мероприятий у пациентов с генерализованным пародон- титом на фоне сахарного диабета І типа с кардиомиопатией на изменения содержания концентраций эндотелина-1 и метаболитов азота в ротовой жидкости в результате применения предложенной авторами схемы в основной группе и у людей группы контроля, где лечение стоматологической болезни проводили по общепринятой методике. Доказано, что у пациентов основной группы вследствие лечения существенно повысилось содержание метаболитов азота на фоне снижения концентрации эндотелина-1 в ротовой жидкости по сравнению с данными в контроле; Abstract. This paper analyzes the efficacy of therapeutic measures for patients with generalized periodontitis and type I diabetes mellitus with cardiomyopathy for changes in the content of concentrations of endothelin-1 and nitrogen metabolites in the oral liquid as the result of use developed own scheme in the main group and control group, where treatment of dental diseases carried out by generally accepted technique. It is proved that patients of the main group as a result of treatment were studied in a significant increase in the content of nitrogen metabolites in the context of reducing the concentration of endothelin-1 in the oral liquid compared to the data of control group. The purpose of this work was to study the changes of concentrations of nitrogen metabolites and endothelin-1 in the oral liquid, using own developed treatment and preventive complex in patients with generalized periodontitis in context of type 1 DM with cardiomyopathy. The material and research methods. The state of periodontal tissues in patients was evaluated by general accepted criteria of dental examination. Diagnosis of periodontal diseases was established according to the classification of M. F. Danilevsky (1994) with additions of I. S. Mashchenko (1997). The diagnosis was specified using periodontal indices. The complex treatment of generalized periodontitis within 127 patients group with generalized periodontitis in context of type 1 diabetes mellitus with cardiomyopathy, divided into two groups: main group (82 people) treatment conducted according to sekf- developed schemes. Control group the treatment of generalized periodontitis was performed according to the standard method by the "Protocols of medical care of Ministry of health of Ukraine on specialty "Therapeutic dentistry". The content of endothelin-1 in the oral fluid determined by ELISA method using a set of reagents. The content of nitrogen metabolites (NO2 + NO3) in the oral liquid of patients determined according to the standard method. The obtained results were statistically worked out. Results of the research and its discussion. Result of treatment and preventive measures for patients of the main group with GP after 6 months of treatment the content of nitrogen metabolites in the oral liquid has increased for all degrees of severity of generalized periodontitis compared to the values before treatment. Patients of control group with GP after 6 months of treatment, where used traditional therapeutic schemes, the content of nitrogen metabolites in the oral liquid was significantly lower at the initial stage – Ist degree of severity of GP relatively to the data before treatment (27.25±1.13 mkmol/l against 30.87±1.12 mkmol/l, p<0.05). Patients of the main group, after 12 months of treatment, demonstrated further decrease of endothelin-1 in the oral liquid relative to the data before treatment: at GP of the initial – Ist degree of severity by 43.84%, at GP of IInd degree of severity by 38.85% and at GP of IIIrd degree of severity by 23.61%, p<0.01. Within control group after 12 months of treatment the content of endothelin-1 was increased in the oral liquid by 21.43% more on initial stages of GP, p<0.05. In advanced forms of generalized periodontitis, the level of endothelin-1 was on 22.95% at GP of IInd degree of severity, p<0.01 and at GP of IIIrd degree of severity by 15.0% , p<0.05 higher relative to the data before treatment. Conclusions. The performed study proved the adequacy of the proposed treatment and preventive scheme in patients of the main group, which is confirmed by the improvement of endothelial function of the vessels of the periodontium, which is expressed by increasing in the concentrations of nitrogen metabolites in context of decrease of endothelin-1 in the oral liquid in this group of patients, in the absence of positive dynamics in the control group, where treatment was performed according to standard methods.Документ Оцінка ефективності застосування лікувально-профілактичного комплексу в пацієнтів із генералізованим пародонтитом, які працюють в умовах тепличних господарств за впливу пестицидів на окремі показники ротової рідини(Українська медична стоматологічна академія, 2017) Заболотний, Тарас Дмитрович; Бандрівська, Надія Нилівна; Дирик, Володимира Тарасівна; Zabolotnyj, T. D.; Bandrivska, N. N.; Dyryk, V. T.Представлена схема комплексного лікування і профілактики запальних захворювань тканин пародонта в працівників тепличних господарств, які зазнають впливу пестицидів. За даними вмісту середньомолекулярних пептидів, лізоциму і sIgA в ротовій рідині досліджуваних доведена адекватність розробленого авторами лікувально-профілактичного алгоритму у віддалені терміни спостереження в порівнянні з аналогічними даними в осіб, лікування яких проводили за традиційними методиками; Представлена схема комплексного лечения и профилактики воспалительных заболеваний тканей пародонта у работников тепличных хозяйств, подвергающихся воздействию пестицидов. По данным содержания среднемолекулярных пептидов, лизоцима и sIgA в ротовой жидкости исследуемых доказана адекватность разработанного авторами лечебно-профилактического алгоритма в отдаленные сроки наблюдения в сравнении с аналогичными данными у лиц, лечение которых проводили по традиционным методикам; Abstract. The periodontal diseases are one of the most common and difficult in the treatment and clinical conduction among the dental diseases. A significant prevalence of periodontal diseases in workers, contact in the process of activity with the unfavorable factors of production environment is relevant and unsolved problem of dentistry. In recent years, the conditions of labour on majority agroindustrial productions tested considerable changes, and their unfavorable characters are established: the amount of production with the low level of sanitary and technological disciplines increased, the system of medical providing of workers, that resulted to rolling up of preventive activity on enterprises and, as a consequence, increase of professional morbidity. The purpose of this research was to estimate the efficacy of use therapeutic preventive complex in patients with generalized periodontitis, working in greenhouses under the influence of pesticides on separate parameters of the oral liquid. The material and research methods. A complex treatment of inflammatory diseases of periodontal tissues was conducted for 120 workers of greenhouses with generalized periodontitis (71 patient of the main group and 49 persons of the control group). Patients with inflammatory diseases of periodontal tissues, which constituted the control group, were treated according to the "Protocols of the Ministry of Healthcare of Ukraine" by specialty "Therapeutic dentistry". Efficacy of the conducted treatment was estimated by the changes of content of medium molecular peptides (MMP) using methodology of А. А. Тоgaibaev and concentrations of lysozyme and sIgA in the oral liquid. The obtained results were worked out statistically. Results of the research and their discussion. For estimation of efficacy of the treatment, using our proposed treatment and preventive complex in patients with inflammatory diseases of periodontal tissues working in agroindustrial production on open and closed soils under the influence of pesticides, the dynamics of changes of the values of medium molecular peptides in the oral liquid in remote treatment terms were analyzed. In 6 months after the treatment in patients with CCG of the main group, the content of MMP in the oral liquid decreased on 31.82 % (0.255±0.03 conv. units of opt. density), p<0.05, while in patients of the control group the value of analyzed indicator increased on 2.60 %, p>0.05. As a result of studies it has been established that in patients with inflammatory diseases of periodontal tissues of the main group in 6 months after the treatment the content of lysozyme and sIgA in the oral liquid increased to 424.20±7.30 mcg/ml and to 0.249±0.016 g/l, respectively, p<0.01. Patients of the control group had a similar tendency: investigated increase of the content of lysozyme in the oral liquid to 393.50±7.25 mg/ml, p<0.05 and sIgA – to 0.225±0.017 g/l, p>0.05. In 12 months after the treatment in patients of the main group, a positive dynamic of increase of immunological parameters was saved. Thus, the content of lysozyme in the oral liquid increased on 22.12 %, the concentration of sIgA increased on 61.11 % compared to the data before treatment, p<0.01. In patients of the control group with inflammatory diseases of periodontal tissues in 12 months after the treatment the value of analyzed immunological parameters decreased and equaled to the data before treatment. Conclusions. The results of conducted studies have shown high efficacy of the worked out complex of the treatment preventive measures for workers of greenhouses with inflammatory diseases of periodontal tissues, working in the conditions of open and closed soils under the influence of pesticides. The efficacy of treatment preventive complex is significantly confirmed by the decrease of level of medium molecular peptides and increased levels of lysozyme and secretory immunoglobulin in the oral liquid.