Перегляд за Автор "Zviagolska, I. M."
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Документ Current strategy for treatment of comorbid states: complicated community-acquired pneumonia with arterial hypertension(Wydawnictwo Aluna, Polska, 2020) Burya, L. V.; Vakhnenko, A. V.; Moiseieva, N. V.; Kapustianska, A. A.; Zviagolska, I. M.; Буря, Лілія Володимирівна; Вахненко, Андрій Вікторович; Моісєєва, Наталія Віталіївна; Капустянська, Анна Анатоліївна; Звягольська, Ірина Миколаївна; Буря, Лилия Владимировна; Вахненко, Андрей Викторович; Моисеева, Наталья Витальевна; Капустянская, Анна Анатольевна; Звягольская, Ирина НиколаевнаThe aim: To optimize the treatment of CAP patients with hypertension, complicated by exudative pleuritis. Materials and methods: The study included 43 CAP patients, aged 46 to 65 years, with viral lesions along with hypertension. The average age of the patients was 52.5 ± 4.5 years. Veri cation of the CAP diagnosis and its formulation was performed in accordance with the order of the Ministry of Health of Ukraine No. 128 of 19.03.2007 “On the approval of clinical protocols of medical care in “Pulmonology” in all patients, pneumonia was complicated by exudative pleuritis, which was con rmed by X-ray examination. Results: The use of combination drugs, namely, torasemide with prolonged e ect and tivortin aspartate in the treatment of patients with community-acquired pneumonia, complicated by exudative pleuritis, combined with hypertension led to more signi cant positive changes in the values of saturation, blood biochemical parameters, as well as accelerated recovery of patients, which was con rmed by the positive dynamics of X-ray examination. Conclusions: As a result of the treatment, all parameters of the quality of life of the patients were greatly improved, which resulted in a signi cant reduction in functional limitations and high social activity of the patients, which signi cantly reduced the cost of treatment.Документ Polymorphism of the nfatc1 gene family as a marker of arterial hypertension progression in adolescents(ESC Biomarkers, 2019) Tanianska, S. M.; Yaroshenko, N. V.; Zviagolska, I. M.; Tanianska, V. E.; Танянська, Світлана Михайлівна; Ярошенко, Наталія Володимирівна; Звягольська, Ірина Миколаївна; Танянська, Валерія Євгеніївна; Танянская, Светлана Михайловна; Ярошенко, Наталья Владимировна; Звягольская, Ирина Николаевна; Танянская, Валерия ЕвгеньевнаArterial hypertension (AH) and its complications at the present stage occupy a leading place in the structure of polymorphism of vascular diseases. The aim of the research is to determine the variability of the NFATCI and NFATC4 genes for the development and progression of hypertension in adolescents. The analysis of the data revealed that the expression rate of the NFATC1 gene in patients with hypertension was 3.06 ± 0.52, and the NFATC4 gene was 18.32 ± 5.62, that is, the expression of these genes significantly exceeded the reference values that were taken for a unit. The study of rs11665469 genotypes of the NFATC1 gene in patients with hypertension: CC– 58%, TT – 25%, CT – 21%. Any significant differences in the group of adolescents with hypertension and in the control group depending on the listed genotypes (p ≥ 0.05) were not found out. The rf222909 genotypes of the NFATC4 gene in adolescents with AH were detected in the ratios: CC– 39%, GG – 21%, CG – 46%, and in adolescents in the control group: CC – 24%, GG – 20%, CG – 54%.Документ West Nile Fever in the central part of Ukraine(Дніпровський державний медичний університет, 2020) Kotelevska, T. M.; Pryimenko, N. O.; Dubynska, H. M.; Koval, T. I.; Iziumska, O. M.; Zviagolska, I. M.; Котелевська, Тетяна Михайлівна; Прийменко, Наталія Олегівна; Дубинська, Галина Михайлівна; Коваль, Тетяна Ігорівна; Ізюмська, Олена Михайлівна; Звягольська, Ірина МиколаївнаWest Nile Fever (WNF) is the most common arbovirus infection with a transmission mechanism caused by West Nile Virus (WNV), present on all continents, except for Antarctica. WNV has a high epidemic potential and is dangerous for health of the population all over the world, due to rapid global spread, the formation of new natural foci and the ability to cause epidemics in endemic areas. Over the past 20 years, there have been numerous epidemic outbreaks of the disease among people, birds and horses, associated with WNV. On the territory of Ukraine WNV was first detected in the 70s of the XX century, but at present clinical and epidemiological aspects have been understudied. This study analyzed the epidemic situation regarding WNF in Poltava Region in 2011- 2018, and clarified the epidemiological and clinical manifestations of serologically confirmed cases of acute WNF. This is the first actual survey of WNF cases in Poltava Region, its results indicate the prevalence of WNV in the central part of Ukraine. The aim of the study was to study the epidemiological and clinical characteristics of West Nile Fever in Poltava Region. The cases of WNF in Poltava Region in 2011-2018 have been analyzed, according to the annual reporting forms of the Ministry of Health of Ukraine. A serological study of pair blood sera for specific IgG-class antibodies to WNV of 232 patients with febrile conditions, requiring screening for WNF, was conducted. The clinical course was studied in a retrospective analysis of 14 case histories of patients with WNF under treatment in the Poltava Regional Clinical Infectious Diseases Hospital. The analysis demonstrated that in Poltava Region in 2011-2018 35 serologically confirmed cases of acute WNF were registered, with the largest number (14) in 2012. Serologic examination of the specific markers of WNV in 232 patients with febrile conditions allowed to detect 57 (24.6%) seropositive patients. Acute WNF was diagnosed in 35 (15,1%) patients, past WNF – in 22 (9,5%) persons. Analysis of case histories of patients with acute WNF showed that the most susceptible ones were females (64.1%), and the average age of the persons was 46.28±0.30 years old. According to the epidemiological history, the city residents dominated among the patients (71.4%), all of them (100%) marked mosquito bites, and the disease was of a seasonal nature, with the largest (78.6%) number of cases in July-August. The clinical course of WNF in all (100%) patients was moderatesevere and characterized by polymorphism of clinical manifestations. The leading clinical syndromes were: intoxication (100.0%), fever (100.0%), catarrhal (50.0%), allergic (42.8%), dyspeptic (35.7%) syndromes and lymphadenopathy (28.5 %). Thus, the conducted researches have shown that there are all conditions for formation of a natural center of WNF on the territory of Poltava Region. WNF was characterized by a typical course of the disease.Документ Комбінована дія ефірної олії монарди трубчастої та протигрибкових препаратів на музейний штам С. Albicans ATCC 10231(Українська медична стоматологічна академія, 2019) Карлінська, І. В.; Зачепило, Світлана Вікторівна; Звягольська, Ірина Миколаївна; Karlinska, I. V.; Zviagolska, I. M.; Zachepylo, S. V.В осанні десятиріччя відмічається зростання грибкових запальних захворювань верхніх дихальних шляхів та вуха. Провідна роль в етіології мікозів ЛОР-органів належить грибам роду Candida, найбільш патогенним залишається C. Albicans. Широке застосування протигрибкових препаратів призводить до формування резистентності збудників до їх дії. Перспективним напрямком подолання антимікотикорезистентності розглядається використання ефірних олій (ЕО). Більшість хімічних сполук, що входять до складу ефірних олій, зумовлюють їх антимікробні, антивірусні, протизапальні, імуномодулюючі властивості. Враховуючи синергічну антимікробну дію антисептиків, антибіотиків та ЕО на мікроорганізми доцільне вивчення комбінованого впливу антимікотиків та ЕО для підвищення ефективності протигрибкової терапії. Мета роботи: вивчення ефективності комбінованої дії ЕО монарди трубчастої та протигрибкових препаратів на музейний штам C. Albicans АТСС 10231.