Вісник проблем біології і медицини, Випуск 1 (168)
Постійне посилання зібрання
Переглянути
Перегляд Вісник проблем біології і медицини, Випуск 1 (168) за Ключові слова "611.438+599.23 +616.438"
Зараз показуємо 1 - 1 з 1
Результатів на сторінці
Налаштування сортування
Документ Structural changes in the thymus under the pathogenic factors action(Полтавський державний медичний університет, 2023) Prykhodko, O. O.; Приходько, О. О.The thymus is the primary lymphoid (immune) organ in which antigen-independent proliferation and differentiation of T-lymphocytes occur and protects the body against various pathogenic factors. A comprehensive study of the morphological features of the thymus is relevant and one of the primary tasks of theoretical and practical medicine. The goal is to analyze and generalize data from the modern scientific literature on structural changes in the thymus under exposure to various exo- and endoantigens. It is possible to predict its further changes and develop methods for their prevention and correction, having followed the patterns of structural reorganization of the thymus under the influence of specific pathogens. The article analyzes data from the literature on the effects of cyclophosphamide, immunofan, salt extract of Hirudo verbana, tobacco smoke, formaldehyde, staphylococcal toxoid, polyoxypropylenetriol triglycidyl ester aqueous solution, adjuvant arthritis, light stress, reticuloendotheliosis virus, ablation therapy on the structural components of the thymus. Data are presented that emphasize the severity of the age-related clinical picture of COVID-19 and SARS-CoV-2, which is explained by insufficient antiviral immune function and an excessive self-destructive immune reaction, which includes T-cell immunity and is associated with already existing chronic inflammation in the human body of elderly. In addition, there is current information on the structure of the thymus and patterns of changes in its structural organization in age-related involution and atrophy. In most cases, due to the short-term exposure of the research animals to various exo- and endoantigens, changes in the thymus of the type of compensatory-adaptive reaction develop; that is, they are not specific.