Вісник проблем біології і медицини, Випуск 1 (168)
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Документ Vitamin D and autoimmune thyroiditis(Полтавський державний медичний університет, 2023) Pivtorak, K. V.; Ivanhuk, O. V.; Півторак, К. В.; Іванчук, О. В.The primary role of vitamin D is the regulation of bone metabolism and the homeostasis of calcium and phosphorus. Over the past several decades, the importance of vitamin D in a variety of aspects unrelated to the skeletal formation has been studied, including the beneficial effects of vitamin D on endothelial dysfunction, insulin resistance and diabetes prevention, beneficial effects on the immune response in infectious diseases including tuberculosis, and immunomodulatory effects in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, metabolic syndrome, cardiovascular disease, cancer, and all-cause mortality. Vitamin D prevents and promotes remission in patients with multiple sclerosis and improves the function of the gonads. The extensive range of vitamin D action is due to the presence of its receptors in many tissues. Recent evidence has shown a connection between low vitamin D levels and autoimmune thyroid diseases, such as Hashimoto's thyroiditis. This review aims to follow the role of vitamin D in the course of autoimmune thyroid disease. Vitamin D deficiency is one of the environmental risk factors for autoimmune thyroid diseases. Despite recent evidence that low serum 25-hydroxyvitamin D levels may influence the development of autoimmune thyroid disorders, the relationship between vitamin D deficiency and autoimmune thyroiditis and the incidence of hypothyroidism remains unclear. Further studies are needed to evaluate vitamin D's preventive and therapeutic effects in autoimmune thyroid diseases.