Features of NF-κB -mediated signal transduction and development of systemic inflammation in patients with diseases of internal organs are determined by microbial factor and individual reactivity of the body (review of own research findings)

Abstract

The paper identifies the etiological significance of periodontopathogenic microflora in the initiation of low-intensity systemic inflammation, which together with insulin resistance and lipid metabolism determines the development of atherosclerosis and coronary heart disease. On the basis of obtained data, the paper substantiates the concept of permanent activation of transcription factor NF-κB as the molecular foundation of systemic inflammation and other components that form the metabolic syndrome. The role of polymorphic variants of TLR 2,4,3,6 genes in shaping the individual reactivity of patients has been determined. The participation of genetic variation of receptor and structural proteins in determining the individual sensitivity, clinical course and complications of infectious diseases – hepatitis C, influenza, and EBV-viral infection has been justified. The up-to-date role of fundamental processes of innate and acquired immunity in the pathogenesis of atopic dermatitis, allergic rhinitis and bronchial asthma has been demonstrated. The efficiency of developed methods of therapy with additional inclusion of metformin and pioglitazone has been demonstrated, the application of pharmacogenetic approach to treatment has been substantiated. The obtained results will contribute to the formation of a systematic approach to the development and use of new technologies for prevention and effective pharmacogenetic treatment of diseases which are based on chronic inflammation.