Functioning of NO-cycle in the oral fluid of children with type 1 diabetes mellitus in the treatment of chronic catarrhal gingivitis

dc.contributor.authorSheshukova, O. V.
dc.contributor.authorKuz, I. O.
dc.contributor.authorKostenko, V. O.
dc.contributor.authorAkimov, O. Ye
dc.contributor.authorMaksymenko, A. I.
dc.contributor.authorPysarenko, O. A.
dc.contributor.authorLyakhova, N. O.
dc.contributor.authorШешукова, Ольга Вікторівна
dc.contributor.authorКузь, Ірина Олексіївна
dc.contributor.authorКостенко, Віталій Олександрович
dc.contributor.authorАкімов, Олег Євгенович
dc.contributor.authorМаксименко, Аліна Іванівна
dc.contributor.authorПисаренко, Олена Анатоліївна
dc.contributor.authorЛяхова, Наталія Олександрівна
dc.date.accessioned2024-04-30T12:30:03Z
dc.date.available2024-04-30T12:30:03Z
dc.date.issued2022
dc.description.abstractThe aim: To determine the activity of NO-synthase and arginase in oral fluid in children with type 1 diabetes mellitus and to evaluate the efficacy of the treatment scheme we elaborated in the treatment of chronic catarrhal gingivitis. Materials and methods: 82 children were examined, they were divided into groups by presence of gingivitis and diabetes mellitus. NO-synthase (NOS) activity was determined in oral fluid by the difference in nitrite concentration before and after incubation. The arginase activity was determined in oral fluid by the difference in the concentration of L-ornithine before and after incubation. Results: Use our treatment scheme in children with chronic catarrhal gingivitis and type 1 diabetes mellitus lead to a change in the polarization of oral macrophages towards the predominance of M2 polarization in 1 month. The polarization of macrophages changed to the predominance of M1 polarization activity in 1 year. Conclusions: We have elaborated a scheme for the treatment of chronic catarrhal gingivitis in children with type 1 diabetes mellitus. It normalizes the polarization of oral macrophages caused by exposure to chronic catarrhal gingivitis as a local pathogenetic factor.uk_UA
dc.identifier.citationFunctioning of NO-cycle in the oral fluid of children with type 1 diabetes mellitus in the treatment of chronic catarrhal gingivitis / O. V. Sheshukova, I. O. Kuz, V. O. Kostenko [et al.] // Wiadomości Lekarskie. – 2022. – Vol. LXXV, issure 3. – P. 654–659.uk_UA
dc.identifier.urihttps://repository.pdmu.edu.ua/handle/123456789/23677
dc.language.isoenuk_UA
dc.publisherAluna Publishinguk_UA
dc.subjecttype 1 diabetes mellitusuk_UA
dc.subjectmacrophagesuk_UA
dc.subjectgingivitisuk_UA
dc.subjectiNO-synthaseuk_UA
dc.subjectarginaseuk_UA
dc.titleFunctioning of NO-cycle in the oral fluid of children with type 1 diabetes mellitus in the treatment of chronic catarrhal gingivitisuk_UA
dc.typeArticleuk_UA

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