Impregnation of oral mucosa over impacted teeth by subpopulations of macrophages M1 and M2
Ескіз недоступний
Дата
2021
Назва журналу
Номер ISSN
Назва тому
Видавець
Aluna Publishing
Анотація
The aim: Of the study is to research quantitative parameters of mucous membrane macrophages populations M1 (CD68+) and M2 (CD163+) over vestibularly and palatally
impacted teeth.
Materials and methods: A group of 21 people aged from 10 to 16 years was formed to conduct the research. Clinical situation according to diagnostic criteria was identical in
all the patients. The group was divided into two groups - control and experimental, which in their turn were fragmented into two subgroups. Immunohistochemical studies of
mucosal biopsies were performed in accordance with the recommendations for selection.
Results: Study of ratio of CD68+/CD163+ cells revealed imbalance in individuals with vestibularly impacted teeth due to higher infiltration density of CD163+ (p<0,05),
compared to CD68+ of control group. In individuals with palatally impacted teeth, ratio of CD68+/CD163+ increased 3,6 times, as well as compared with control group, but
due increased infiltration density of CD68+.
Conclusions: In the epithelium of oral mucosa located over impacted teeth, both on vestibular and palatal surface, number of CD 68+ and CD163+ cells had no significant
differences compared to control group. In biopsies of the lamina propria of mucosa over vestibularly impacted teeth, the ratio M1/M2=0,91±0,11 (p<0,05) decreases, with
predominance of macrophages CD163+ subpopulation activity, and over palatally impacted teeth balance of M1/ M2 macrophages elevated (M1/M2= 2,10 ± 0,32, p<0,05),
due to increased infiltration density of CD68+.
Опис
Ключові слова
children, macrophages, impacted teeth, surgical and orthodontic treatment
Бібліографічний опис
Impregnation of oral mucosa over impacted teeth by subpopulations of macrophages M1 and M2 / P. I. Tkachenko, M. І. Dmytrenko, M. О. Cholovskyi [et al.] // Wiadomości Lekarskie. – 2021. – Vol. LXXIV, issue 6. – P. 1451–1456.