2024
Постійне посилання на фонд
Переглянути
Перегляд 2024 за Автор "Avetikov, D. S."
Зараз показуємо 1 - 4 з 4
Результатів на сторінці
Налаштування сортування
Документ Application of platelet-riched plasma in the complex treatment of patients with complete dislocation of maxillary teeth(Полтавський державний медичний університет, 2024-03-20) Ivanytska, O. S.; Bilash, S. M.; Lychman, V. O.; Toropov, O. A.; Avetikov, D. S.; Horban, I. I.; Іваницька, Олена Сергіївна; Білаш, Сергій Михайлович; Личман, Віталій Олександрович; Торопов, Олександр Анатолійович; Аветіков, Давид Соломонович; Горбань, І. І.Restoring the connection between the tooth and the periodontium is the primary goal of complex treatment, which involves the formation of new bone and cement, restoring the periodontal ligament and blood supply to the pulp from the surrounding tissues. The study aimed to investigate the effect of platelet-rich plasma as a medium for temporarily storing a dislocated tooth on the regeneration and reconstruction of its tissues after replantation of an extracted tooth compared to saline and water. In this study, 30 adult male Wistar rats were used, and a tooth was extracted and then replanted. A fibroblast cell activity analysis was performed after 72 hours to determine cell viability. Cells incubated in platelet-rich plasma medium had a higher percentage of cell viability (82.7±5.1), followed by saline (74.3±4.2) with statistical significance (p>0.001). The minimum percentage was recorded in cells in the medium with tap water (68.8±3.9). The pulp, dentin and cementum of the group where the teeth were placed in platelet-rich plasma showed normal histological features, demonstrating optimal tissue remodelling and attachment to the surrounding bone. There were no signs of root resorption. In summary, this study used several temporary storage procedures and evaluated changes in histological events that occurred during the storage of extracted teeth and replantation until the time of recording of the success of the replantation. The study's results indicate the use of platelet-rich plasma as a storage medium, as it significantly preserves the viability of dental cells compared to water and saline solutions.Документ Effect of quercetin on lipid peroxidation state in experimental chemical rhinitis caused by alkaline burn(Полтавський державний медичний університет, 2024-03-20) Netyukhailo, L. G.; Avetikov, D. S.; Hasiuk, Yu. A.; Нетюхайло, Лілія Григорівна; Аветіков, Давид Соломонович; Гасюк, Юрій АнатолійовичTreating inflammatory diseases of the nasal mucosa, particularly rhinitis, is one of the most pressing issues in medicine. Rhinitis is usually infectious and often seen in influenza and respiratory viral infections. This pathology can lead to dangerous complications, such as inflammation of the nasal cavity and paranasal sinuses, meningoencephalitis, brain abscess, and others. It is well known that inflammation is the basis for developing rhinitis. Inflammation involves several complex molecular reactions aimed at tissue repair and the fight against harmful factors. A significant amount of scientific research has been conducted to investigate the potential of antioxidants to prevent diseases that occur in the context of inflammation. However, the results have led to considerable uncertainty about the impact of antioxidants on inflammation. This prompted the need to study this issue as part of our work. In view of the above, there is a need to conduct studies using quercitin as a potential antioxidant agent. It will allow us to determine the effect of antioxidant properties on the course of the disease, particularly on the development of rhinitis. Quercitin, due to its antioxidant properties, protects the body from free radical damage and may be useful in treating various diseases. This study aimed to investigate the effect of quercetin on lipid peroxidation (LPO) during experimental chemical rhinitis. Chemical rhinitis was induced using a wet swab moistened with a 40% caustic soda solution inserted into each nostril. The drug is a bioflavianoid with the active ingredient quercetin. Assessment of the state of lipid peroxidation in the blood was performed by the following indicators: the content of diene conjugates (DC) - the initial products of lipid peroxidation, TBA-reagents. Indicators were studied in blood serum on the third and fourteenth days of the experiment.Документ Polyps-changed mucosa of the ostiomeatal complex in chronic rhinosinusitis(Полтавський державний медичний університет, 2024-03-20) Hasiuk, Yu. A.; Avetikov, D. S.; Netyukhailo, L. G.; Гасюк, Юрій Анатолійович; Аветіков, Давид Соломонович; Нетюхайло, Лілія ГригорівнаThe purpose of the study was to determine the morphological changes that occur in the polypoidal mucosa of the osteomeatal complex in chronic rhinosinusitis. For the study, the surgical material was used - polypomatous mucosa of the osteomeatal complex obtained during FESS. In many cases, modern treatment methods are unable to provide long-term remission of the disease. This prompts the search for new methods of surgical and medical rehabilitation of the mucous membrane in chronic rhinosinusitis, the polypoidal mucosa of the osteomeatal complex is covered with goblet-transformed epithelium, which is unable to perform the transport function of the mucociliary apparatus in themeatus. In the intrinsic layer of the mucous membrane, edema occurs first, which has a vascular origin, and then leukocyte infiltration occurs, which blocks the ostiomeatal complex. Inhibition of mucociliary transport and blockade of the osteomeatal complex are the main pathogenetic factors in the occurrence of exacerbation of chronic rhinosinusitis. Dysregenerative processes in the stromal component also play an essential role in the genesis of polyposis changes in the mucous membrane. Our studies indicate that in chronic rhinosinusitis, the polypoidal mucosa of the ostiomeatal complex is covered with goblet-transformed epithelium, which is unable to perform the transport function of the mucociliary apparatus in the middle nasal meatus. The obtained materials were used to make histological preparations according to generally accepted methods, which were stained with histological and histochemical stains. In chronic rhinosinusitis, the polyposis-altered mucosa of the osteomeatal complex is covered with goblet-transformed epithelium. The mucosa has edema with a pronounced vascular genesis. Blockade of the ostiomeatal complex is the main pathogenetic factor in the occurrence of exacerbation of chronic rhinosinusitis.Документ The role of immunogram in the diagnostics of chronic sialoadenitis and tumors of the salivary glands(Полтавський державний медичний університет, 2024-03-20) Havryliev, V. M.; Avetikov, D. S.; Pronina, O. M.; Skikevych, M. G.; Yatsenko, I. V.; Bukhanchenko, O. P.; Гаврильєв, Віктор Миколайович; Аветіков, Давид Соломонович; Проніна, Олена Миколаївна; Скікевич, Маргарита Георгіївна; Яценко, Ігор Володленович; Буханченко, Ольга ПетрівнаEpidemiological studies show a high prevalence of dental caries among children in Ukraine, ranging from 53.84% to 96.67%. Somatic pathology is a significant risk factor for the onset and development of caries. In Ukraine, the number of children in need of mental development correction is growing. Therefore, our study aimed to investigate the features of dental caries in children with neuropsychiatric disorders. We examined 108 children aged 13-18 years with neuropsychiatric disorders (main group) and 86 practically healthy children (comparison group). The main group consisted of 48 children with mild to moderate mental retardation, 38 children with autism, and 22 children with Down syndrome. We studied the prevalence of caries (in %), caries intensity (CSI) and level of dental care (LDC). It was found that in children with neuropsychiatric disorders, the prevalence of dental caries is significantly higher than in children in the comparison group and on average is 92.60±2.52% with a caries intensity of 8.56±0.54 teeth, and 75.58±4.63% and CSI = 5.17±0.47 teeth, respectively (p<0.001). It was found that the prevalence of caries was higher in children with Down syndrome than in children with mild mental retardation and autism. The level of dental care for children was analyzed and it was found that children aged 13-15 years, including the comparison group, have an insufficient level of dental care, which is, however, at the age of 16-18 years the level of dental care has significantly improved